Plant Steroidal Saponins: A Focus on Open-Chain Glycosides

Challinor, Victoria L.; Voss, James J. De

doi:10.1007/978-3-642-22144-6_139

Cited by 3 publications

(7 citation statements)

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“…25−27 The broad range of these bioactivities is likely attributable to their structural diversity, arising from different aglycone skeletons, hydroxylation patterns of the steroidal nucleus and varying identity, number and attachment positions of sugar groups. 24 Within steroidal saponins, there are two well-known structural classes: hexacyclic spirostanols, with a bicyclic acetal at C-22, and pentacyclic furostanols, with a hemiacetal at C-22 and a C-26 glycosidic bond (Figure 1). More recently, a third class has been added.…”

Section: ■ Introductionmentioning

confidence: 99%

“…This third class of steroidal saponins has been recently surveyed by Challinor and De Voss. 24,28 C. luteum, also known as false unicorn, was traditionally used by Native Americans to strengthen the heart and treat nausea, coughs, and female reproductive issues, including miscarriage prevention and prolapse. 29,30 The herbal extract has continued to be used for regulating menses, promoting fertility, and preventing miscarriage.…”

Section: ■ Introductionmentioning

confidence: 99%

“…Diverse hydrophilic sugar moieties can decorate this central skeleton at a variety of attachment points (Figure ). These natural products are the proposed active constituents in numerous herbal medicines and traditional therapies. , A large range of bioactivities have been attributed to steroidal saponins, including cytotoxic, anti-inflammatory, anti-bacterial, anti-fungal, and haemolytic activities. − The broad range of these bioactivities is likely attributable to their structural diversity, arising from different aglycone skeletons, hydroxylation patterns of the steroidal nucleus and varying identity, number and attachment positions of sugar groups …”

Section: Introductionmentioning

confidence: 99%

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Caco-2 Monolayer Permeability and Stability of Chamaelirium luteum (False Unicorn) Open-Chain Steroidal Saponins

Stockdale

Challinor

Lehmann³

et al. 2019

ACS Omega

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Herbal medicines, although significant components of health care for much of the global populace, are still far less stringently regulated than conventional pharmaceuticals. Safety and efficacy concerns arise because of the limited information regarding many of the phytochemicals present in herbal medicines. Chamaelirium luteum (false unicorn) is an indigenous American herb marketed for "women's issues". Recently, the potential bioactives, a new class of open-chain steroidal saponins, have been fully characterized and preliminary bioactivity assays have been performed. The present study utilized the Caco-2 cell monolayer model to evaluate metabolic vulnerability and potential bioavailability of eight saponins and sapogenins from false unicorn. No compound metabolism was detected in Caco-2 cell homogenate. One sapogenin, helogenin, exhibited low-to-moderate permeability across the monolayers. Three saponinschamaeliroside A, heloside A, and 6-dehydrochamaeliroside Awere found to have moderate permeability. Transport studies indicated active transport of these saponins. In contrast, all saponins with more than two sugar units exhibited low permeability.

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Section: ■ Introductionmentioning

confidence: 99%

Section: ■ Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Caco-2 Monolayer Permeability and Stability of Chamaelirium luteum (False Unicorn) Open-Chain Steroidal Saponins

Stockdale

Challinor

Lehmann³

et al. 2019

ACS Omega

Self Cite

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“…Steroidal saponins vary in structure because of their various patterns of steroidal oxygenation and glycosylation (Challinor et al 2013;Wang and Hou 2008), which may be associated with a broad range of biological activities, such as cytotoxic (Wen et al 2015), antiulcer (Júnior et al 2015), hypolipidemic, anti-inflammatory, antioxidant, and antifungal effects (Sparg et al 2004;Weng et al 2014). Glycosylation may be not only involved in stabilizing the products but also regulating their biological activities and governing intracellular distribution (Bruyn et al 2015;Schuler et al 1991;Ullmann et al 1993;Webb et al 1995).…”

Section: Introductionmentioning

confidence: 99%

Identification and functional characterization of DzS3GT, a cytoplasmic glycosyltransferase catalyzing biosynthesis of diosgenin 3-O-glucoside in Dioscorea zingiberensis

Song

Zhang

et al. 2017

Plant Cell Tiss Organ Cult

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“…Also, it does not need sample preparation, where the same samples can be measured several times since there is no change in their characteristics after the first trial of measurements [11][12][13]. ET has been used in: (i) biotechnology applications, (ii) food industry, (iii) olive oil authentication and adulteration, (iii), and most importantly, oral pharmaceutical product evaluation [12,[14][15][16][17][18][19][20][21][22][23].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Taste, Total Phenols and Antioxidant for Fresh, Roasted, Shade dried and Boiled leaves of Edible Arum palaestinum Bioss

Qneibi¹,

Jaradat²,

Zaid³

et al. 2018

mpj

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ABSTRACT:Arum palaestinum is one of the famous wild plants that have been used since the ancient time in the Palestinian folk food and medicine. However, it needs particular cooking steps to decrease its numbing taste. We investigated the impact of cooking, measures on taste, total phenols and antioxidant activity of wild A. palaestinum by using an Alpha-Astree Electronic tongue (ET), which is used for food taste assessment. In this study, the A. palaestinum was cooked in different ways. We used Folin Ciocalteu's process to compare total phenols, where radical scavenging assay was used to evaluate the antioxidant activity using 2, 2-diphenyl-1-picrylhydrazyl-hydrate (DPPH). Our results showed that a very significant discrimination of the samples with different distances between groups (p-values < 0.001) in the ET results coupled with the principal component analysis (PCA). The samples were in the following order in term of numbing taste: Fresh > dried > cooked. Moreover, the pattern discrimination index between (A and C), (B and C) and (A and B) were 88%, 96.36%, and 98%, respectively, which suggests that C and A are the most similar preparations in term of taste, while B is the worst one. Our results reveal that the cooking and dried A. palaestinum showed a lower numbing taste by ET, while the antioxidant activities showed a marked correlation with the total phenolic contents. As a result, we concluded that the oven dried preparing method (home roasting) for A. palaestinum is the most efficient method for consumption or preparing bioactive supplements for nutraceutical and pharmaceutical supplements.

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Plant Steroidal Saponins: A Focus on Open-Chain Glycosides

Cited by 3 publications

References 111 publications

Caco-2 Monolayer Permeability and Stability of Chamaelirium luteum (False Unicorn) Open-Chain Steroidal Saponins

Caco-2 Monolayer Permeability and Stability of Chamaelirium luteum (False Unicorn) Open-Chain Steroidal Saponins

Identification and functional characterization of DzS3GT, a cytoplasmic glycosyltransferase catalyzing biosynthesis of diosgenin 3-O-glucoside in Dioscorea zingiberensis

Evaluation of Taste, Total Phenols and Antioxidant for Fresh, Roasted, Shade dried and Boiled leaves of Edible Arum palaestinum Bioss

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