Plant Steroids: Occurrence, Biological Significance, and Their Analysis

Gunaherath, G. M. Kamal B.; Gunatilaka, A. A. Leslie

doi:10.1002/9780470027318.a9931.pub2

Cited by 6 publications

(5 citation statements)

References 113 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…substituents at C-10 and C-13 and alkyl substituent at C-17. The oxidation states of these tetracyclic carbon cores and methyl groups and their structure chain exhibit immense chemical diversity of steroids (Gunaherath & Gunatilaka, 2020). Based on taxonomic considerations and biological structures, plant steroids can be classified into seven major classes (Kreis & Müller-Uri, 2018) (Table 1).…”

Section: Methodsmentioning

confidence: 99%

Pharmacologic activities of phytosteroids in inflammatory diseases: Mechanism of action and therapeutic potentials

Marahatha

Gyawali

Sharma

et al. 2021

Phytotherapy Research

View full text Add to dashboard Cite

Natural products and their derivatives are known to be useful for treating numerous diseases since ancient times. Because of their high therapeutic potentials, the use of different medicinal plants is possible to treat varied inflammation‐mediated chronic diseases. Among natural products, phytosteroids have emerged as promising compounds mostly because they have diverse pharmacological activities. Currently, available medications exert numerous systemic toxicities, including hypertension, immune suppression, osteoporosis, and metabolic abnormalities. Thus, further research on phytosteroids to subside these complications is of significant importance. In this study, the information on phytosteroids, their types, and actions against inflammation, and allergic complications was collected by a systematic survey of literature on several scientific search engines. The literature review suggested that phytosteroids exhibit antiinflammatory action via different modes through transrepression or selective COX‐2 enzymes. Also, in silico ADMET analysis was carried out on available phytosteroids to uncover their pharmacokinetic properties. Our analysis has shown that eight compounds: withaferin A, stigmasterol, β‐sitosterol, guggulsterone, diosgenin, sarsasapogenin, physalin A, and dioscin, −isolated from medicinal plants show similar pharmacokinetic properties as compared to dexamethasone, commercially available glucocorticoid. These phytosteroids could be useful for the treatment of inflammatory diseases, such as rheumatoid arthritis, inflammatory bowel diseases, multiple sclerosis, asthma, and cardiovascular diseases. Thus, systematic research is required to explore potent phytosteroids with lesser side effects, which might substitute the current medications.

show abstract

Section: Methodsmentioning

confidence: 99%

Pharmacologic activities of phytosteroids in inflammatory diseases: Mechanism of action and therapeutic potentials

Marahatha

Gyawali

Sharma

et al. 2021

Phytotherapy Research

View full text Add to dashboard Cite

show abstract

“…Phytosterols represent a large family of naturally occurring lipophilic compounds found in the cell membranes of plants and they have an important role in the regulation of many cellular functions [103,104]. It has been reported that the phytosterols, such as β-sitosterol, stigmasterol, and lanosterol (Figure 8), were identified in the tissue of A. cepa [105].…”

Section: Steroidsmentioning

confidence: 99%

Allium Species in the Balkan Region—Major Metabolites, Antioxidant and Antimicrobial Properties

et al. 2023

View full text Add to dashboard Cite

Ever since ancient times, Allium species have played a significant role in the human diet, in traditional medicine for the treatment of many ailments, and in officinal medicine as a supplemental ingredient. The major metabolites of alliums, as well as their antioxidant and antimicrobial properties, with an emphasis on the species most represented in the Balkan region, are discussed in this review. Due to its richness in endemic species, the Balkan region is considered the genocenter of alliums. There are 56 recorded Allium species in the Balkans, and 17 of them are endemic. The most common and well-studied Allium species in the Balkans are A. cepa (onion), A. sativum (garlic), A. ampeloprasum (leek), A. schoenoprasum (chives), A. fistulosum (Welsh onion), and A. ursinum (wild garlic or bear’s garlic), which are known for their pungent taste and smell, especially noticeable in garlic and onion, and attributed to various organosulfur compounds. These plants are valued for their macronutrients and are used as desirable vegetables and spices. Additionally, phytochemicals such as organosulfur compounds, phenolics, fatty acids, and saponins are associated with the antioxidant and antimicrobial properties of these species, among many other bioactivities. All parts of the plant including the bulb, peel, clove, leaf, pseudostem, root, flower, and seed exhibit antioxidant properties in different in vitro assays. The characteristic phytocompounds that contribute to the antimicrobial activity of alliums include allicin, ajoene, allyl alcohol, and some diallyl sulfides. Nanoparticles synthesized using Allium species are also recognized for their notable antimicrobial properties.

show abstract

“…This makes the screening of saponins needs adjustment on the temperature. Steroids are compounds that are composed of four fused rings and are categorized into a few types [18]. Some of them serve as functional hormones which for example estrogen, progesterone, corticoids, and androgen.…”

Section: Introductionmentioning

confidence: 99%

Screening of Costus speciosus and Determination of Antioxidant Potential Using DPPH Method: A Review

Delarosa,

Hendrawan,

Halimah

2023

EJMP

View full text Add to dashboard Cite

Medicinal plants are garnering widespread interest in scientific circles due to their consistent pharmacological activities, which make them beneficial in the treatment of a variety of ailments. Costus speciosus, commonly known as crepe ginger, is an herbaceous plant native to Mexico that belongs to the family Costaceae (zingiberaceae). Creep Ginger is known to have many medicinal effects, such as antioxidant, anti-inflammatory, and potential antidiabetic activities. The aim of this review was to investigate the phytochemical compounds and potential antioxidant activity in Costus speciosus. The following information on the phytoconstituents of the species Costus speciosus was acquired from online scientific databases using NCBI, Pubmed, Google Scholar, Science Direct, Molecules, Elsevier, and Research Gate searches. Phytochemical analysis from several studies showed the presence of alkaloids, flavonoids, steroids, phenolic compounds, tannins, terpenoids, and saponins in the extract. The parts of Costus speciosus that are used as medicinal plants are usually the leaf, rhizome, and roots. The results suggest that the presence of a wide range of phytochemical compounds from extracts of Costus speciosus may be used to estimate potential antioxidant activity using the DPPH methods. Extracts with methanol as a solvent show that DPPH has considerable antiscavenging activity and the present study on alkaloids indicates that their contents are responsible for the high antioxidant activity. Antioxidant capacity is indicated by the values of EC50 and IC50. This review study may help future research activities on Costus speciosus by providing up-to-date information and relevant data.

show abstract

Plant Steroids: Occurrence, Biological Significance, and Their Analysis

Cited by 6 publications

References 113 publications

Pharmacologic activities of phytosteroids in inflammatory diseases: Mechanism of action and therapeutic potentials

Pharmacologic activities of phytosteroids in inflammatory diseases: Mechanism of action and therapeutic potentials

Allium Species in the Balkan Region—Major Metabolites, Antioxidant and Antimicrobial Properties

Screening of Costus speciosus and Determination of Antioxidant Potential Using DPPH Method: A Review

Contact Info

Product

Resources

About