Plantago asiatica L. Seed Extract Improves Lipid Accumulation and Hyperglycemia in High-Fat Diet-Induced Obese Mice

Abstract

Obesity and its common association with type 2 diabetes, dyslipidemia, and cardiovascular diseases are worldwide epidemics. Currently, to prevent or treat obesity and associated metabolic disorders, herbal dietary supplements or medicines have attracted more and more attention owing to their relative effectiveness with fewer significant side effects. We investigate the therapeutic effects and underlying mechanisms of Plantago asiatica L. seed extract (PSE) on obesity and associated metabolic disorders in high-fat (HF) diet-induced mice. Our results displayed that PSE did not modify food intake or body weight but decreased abdominal white adipose tissue ratio, white/brown adipocyte size, serum total cholesterol, triglyceride (TG), low density lipoprotein cholesterol, free fatty acid, and hepatic TG concentrations when compared with the HF group. The levels of fasting blood glucose and glucose tolerance were improved in the PSE group when compared with the HF group. Furthermore, PSE upregulated mRNA expressions of peroxisome proliferator activated receptors (PPARs) and target genes related to fatty acid metabolism and energy expenditure in liver and adipose tissue of obese mice when compared with the HF group. PSE treatment effectively improved lipid and glucose metabolism in HF diet-induced obese mice. These effects might be attributed to the upregulation of PPAR signaling

Effect of Sheng‐Jiang Powder on Obesity‐Induced Multiple Organ Injuries in Rats

“…The above changes were attenuated with SJP treatment. In accordance with the present study, numerous studies have demonstrated similar changes in high-fat diet induced obesity and Traditional Chinese herb showed a great potential to improve obesity-induced inflammatory injuries via ameliorating inflammation response [ 36 , 37 ], modulating microbiota hemostasis [ 38 , 39 ] and lipid metabolism [ 40 – 43 ], and attenuating insulin resistance [ 44 ]. In a part of the above-mentioned Chinese herb formula, we found similar ingredients in SJP, such as rhein [ 38 ] and Curcuma longa [ 40 ], which might be the main effective constituent of the classic formula.…”

Renoprotective Effect of Plantago major Against Proteinuria and Apoptosis Induced by Adriamycin in Rat

“…In the present work, the renoprotective action of P. major extract was also observed by the time- dependent restoration of serum cholesterol in ADR injected rats. Recently, the hypolipidaemic properties of Plantago ovata husk and Plantago asiatica in diabetic rabbits and obese mice were reported [ 21 , 22 ]. The exact mechanism for this hypolipidemic action of P. major extract in our study is not clear, but it might be contributed to its protection against proteinuria and subsequent hyperalbuminemia, which could minimize the compensatory production of cholesterol by the liver.…”

“…The exact mechanism for this hypolipidemic action of P. major extract in our study is not clear, but it might be contributed to its protection against proteinuria and subsequent hyperalbuminemia, which could minimize the compensatory production of cholesterol by the liver. However, other mechanisms including suppressing fatty acid synthesis, accelerating fatty acid β -oxidation, and stimulating cholesterol catabolism mainly by phenylpropanoid glycosides might be involved [ 22 , 23 ].…”

Modeling Diet‐Induced Metabolic Syndrome in Rodents

“…All data presented herein were obtained from refs. [44,54,55,70,72,74,75,78,88,95,96,98,102–111,116,119–121,124–130,132,134–137,140–144,147–156,158,159,161,163–171,173–176...…”