Plantago lanceolata as a source of health-beneficial phytochemicals: Phenolics profile and antioxidant capacity

Bahadori, Mir Babak; Sarıkürkçü, Cengiz; Kocak, Mehmet Sefa; Calapoğlu, Mustafa; Uren, Mehmet Cemil; Ceylan, Olcay

doi:10.1016/j.fbio.2020.100536

Cited by 32 publications

(34 citation statements)

References 25 publications

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“…Chemical composition. Carbohydrates (Jiang et al, 2019); flavonoids (apigenin, luteolin and their derivatives) (Haddadian and Zahmatkash, 2014;Ferrazzano et al, 2015); iridoid glycosides (aucubin and catalpol as the main ones) (EMA, 2014b;Lotter et al, 2017;Hasan et al, 2018); phenylethanoids (Bahadori et al, 2020); saponins (Wichtl, 2004); tannins (Wichtl, 2004;Grigore et al, 2015); and essential oil (amyl vinyl carbinol (E),4(3-oxo-2,6,6-trimethylcyclo-hex-2-en-1-yl)-3-buten-2-ol, 6-(3-hydroxy-1-butenyl)-1,5,5-trimethyl-7-oxabicyclo[4,1,0] heptan-3-ol, and benzoic acid as major components) (Fons et al, 1998;Bajer et al, 2016).…”

Section: Plantago Lanceolata L -Plantaginaceae (Leaves)mentioning

confidence: 99%

COVID-19: Is There Evidence for the Use of Herbal Medicines as Adjuvant Symptomatic Therapy?

et al. 2020

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Background: Current recommendations for the self-management of SARS-Cov-2 disease (COVID-19) include self-isolation, rest, hydration, and the use of NSAID in case of high fever only. It is expected that many patients will add other symptomatic/adjuvant treatments, such as herbal medicines. Aims: To provide a benefits/risks assessment of selected herbal medicines traditionally indicated for "respiratory diseases" within the current frame of the COVID-19 pandemic as an adjuvant treatment. Method: The plant selection was primarily based on species listed by the WHO and EMA, but some other herbal remedies were considered due to their widespread use in respiratory conditions. Preclinical and clinical data on their efficacy and safety were collected from authoritative sources. The target population were adults with early and mild flu symptoms without underlying conditions. These were evaluated according to a modified PrOACT-URL method with paracetamol, ibuprofen, and codeine as reference drugs. The benefits/risks balance of the treatments was classified as positive, promising, negative, and unknown. Results: A total of 39 herbal medicines were identified as very likely to appeal to the COVID-19 patient. According to our method, the benefits/risks assessment of the herbal medicines was found to be positive in 5 cases (Althaea officinalis, Commiphora molmol, Glycyrrhiza glabra, Hedera helix, and Sambucus nigra), promising in 12 cases (Allium sativum, Andrographis paniculata, Echinacea angustifolia, Echinacea purpurea, Eucalyptus globulus essential oil, Justicia pectoralis, Magnolia officinalis, Mikania glomerata, Pelargonium sidoides, Pimpinella anisum, Salix sp, Zingiber officinale), and unknown for the rest. On the same grounds, only ibuprofen resulted promising, but we could not find compelling evidence to endorse the use of paracetamol and/or codeine. Conclusions: Our work suggests that several herbal medicines have safety margins superior to those of reference drugs and enough levels of evidence to start a clinical

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Section: Plantago Lanceolata L -Plantaginaceae (Leaves)mentioning

confidence: 99%

COVID-19: Is There Evidence for the Use of Herbal Medicines as Adjuvant Symptomatic Therapy?

et al. 2020

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“…Conversely, they found syringic, cinnamic, caffeic, ferulic acids, rutin, catechin and quercetin that were not detected in our study, but they performed the extraction with 70% ethyl alcohol and the phenological stage was not indicated. In contrast, Bahadori et al [ 4 ] found chlorogenic acid in leaves, buds and flowers of plantain, and Nichita et al [ 42 ] detected chlorogenic acid in plantain leaves with mass spectrometer instrument LCMS. Chlorogenic acid (CGA, 3-CQA) is the most abundant isomer among caffeoylquinic acid isomers (3-, 4-, and 5-CQA), currently known as 5-CQA as per guidelines of IUPAC, demonstrating very valuable actions involving anti-inflammation and antioxidant properties.…”

Section: Resultsmentioning

confidence: 99%

“…Plantago lanceolata L. (narrowleaf plantain, plantain, thereinafter plantain) is common in roadside grassland with a worldwide distribution, as perennial, rarely annual or biennial species, representing an interesting multipurpose plant. It grows in the spontaneous flora of Central Europe and is widely used in folk medicine [ 2 , 3 ] for its valuable source of health-beneficial phytochemicals [ 4 ]. Concurrently, plantain is a herb with a broad distribution in grasslands throughout the temperate world.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant Contents in a Mediterranean Population of Plantago lanceolata L. Exploited for Quarry Reclamation Interventions

Sanna

Piluzza

Campesi

et al. 2022

Plants

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Plantago lanceolata L. (plantain) is an interesting multipurpose perennial species whose aerial parts are used in herbal medicine due to its precious phytochemicals and are palatable to animals. Moreover, peculiar traits such as drought tolerance, an extended growth season and a deep root system, make plantain a promising pioneer plant for quarry reclamation based on the use of native species. This study evaluated the effects of different environmental conditions and seasons on the accumulation of the bioactive compounds of its aerial organs. An autochthonous plantain population was grown in three locations in Sardinia (Italy). Leaves, peduncles and inflorescences were collected between October 2020 and July 2021. Phenolic contents and antioxidant capacity were determined. The analysis of the individual phenolic compounds was performed using liquid chromatography. In leaves, the content of total phenolics, antioxidant capacity and total flavonoids were significantly influenced by location and season. Total phenolic content ranged from 65 to 240 g gallic acid equivalent kg−1, whereas total flavonoids were from 16 to about 89 g catechin equivalent kg−1. Neochlorogenic, chlorogenic, cryptochlorogenic acids, verbascoside, diosmin and luteolin were identified in the methanolic extracts of leaves, peduncles and inflorescences. Verbascoside was the main antioxidant isolated from plantain extracts. Results evidenced an increasing accumulation pattern of phenolics from vegetative stage to flowering, followed by a decrement towards the seed ripening as well as site-specific differences with amounts of phenolics even 25% higher for same plantain accession.

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“…Several review papers present the potential uses of, in example, P. lanceolata , P. ovata or polysaccharide from Plantago sp. in this area [ 27 , 29 , 65 , 66 ]. These works could constitute a good starting point for the development of new nutraceuticals based on P. media.…”

Section: Plantago Media L Future Perspectivesmentioning

confidence: 99%

Plantago media L.—Explored and Potential Applications of an Underutilized Plant

Fierăscu

Orţan

et al. 2021

Plants

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The search of valuable natural compounds should be directed towards alternative vegetal resources, and to the re-discovery of underutilized plants. Belonging to the Plantaginaceae family, the hoary plantain (Plantago media L.) represents one of the lesser studied species from the Plantago genus. The literature study revealed the under-utilization of the hoary plantain, a surprising aspect, considering its widespread. If the composition of Plantago media L. is rather well established, its applications are not nearly studied as for other Plantago species. The goal of the present paper is to summarize the findings regarding the applications of P. media, and, having as starting point the applications of related species, to propose new emerging areas of research, such as the biomedical applications validation through in vivo assays, and the evaluation of its potential towards industrial applications (i.e., development of food or personal care products), pisciculture or zootechny, phytoremediation and other environmental protection applications, or in the nanotechnology area (materials phytosynthesis). The present work constitutes not only a brief presentation of this plant’s present and potential applications, but also an invitation to research groups world-wide to explore the available vegetal resources.

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Plantago lanceolata as a source of health-beneficial phytochemicals: Phenolics profile and antioxidant capacity

Cited by 32 publications

References 25 publications

COVID-19: Is There Evidence for the Use of Herbal Medicines as Adjuvant Symptomatic Therapy?

COVID-19: Is There Evidence for the Use of Herbal Medicines as Adjuvant Symptomatic Therapy?

Antioxidant Contents in a Mediterranean Population of Plantago lanceolata L. Exploited for Quarry Reclamation Interventions

Plantago media L.—Explored and Potential Applications of an Underutilized Plant

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