Plantain-based diet decreases oxidative stress and inflammatory markers in the testes of rats exposed to atrazine

Rotimi, Damilare; Adeyemi, Oluyomi Stephen

doi:10.1007/s11010-022-04639-2

Cited by 7 publications

(1 citation statement)

References 55 publications

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“…It is well-documented that combining drugs is a good therapeutic option, and besides quercetin, several other drugs and natural products have been shown to have ameliorative effects on testicular damage. Portulaca oleracea, an annual herbaceous plant, showed testicular protection in Streptozotocin-induced type 1 diabetic rats, mainly in terms of attenuation of oxidative stress and improvement of sperm parameters [141]; a plantain-based diet also showed improvement of oxidative stress and inflammation levels in the testes of rats after atrazine exposure [142]; resveratrol enhanced testicular antioxidant activity and attenuated iron-exposure-induced sperm quality impairment [143] and testicular apoptosis in mice with type 1 diabetes [144], etc. The benefits of quercetin in combination with sitagliptin have been demonstrated [99], but whether the above or other drugs and natural products in combination with quercetin will have a better effect on testicular damage is still unknown and needs to be explored in further studies.…”

Section: The Application Prospects and Limitations Of Quercetinmentioning

confidence: 99%

Pharmacological Activity of Flavonoid Quercetin and Its Therapeutic Potential in Testicular Injury

Zhang

Tang

et al. 2023

Nutrients

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Quercetin is a natural flavonoid widely found in natural fruits and vegetables. Recent studies have shown that quercetin mediates multiple beneficial effects in a variety of organ damage and diseases, and is considered a healthcare supplement with health-promoting potential. Male infertility is a major health concern, and testicular damage from multiple causes is an important etiology. Previous studies have shown that quercetin has a protective effect on reproductive function. This may be related to the antioxidant, anti-inflammatory, and anti-apoptotic biological activities of quercetin. Therefore, this paper reviews the mechanisms by which quercetin exerts its pharmacological activity and its role in testicular damage induced by various etiologies. In addition, this paper compiles the application of quercetin in clinical trials, demonstrating its practical effects in regulating blood pressure and inhibiting cellular senescence in human patients. However, more in-depth experimental studies and clinical trials are needed to confirm the true value of quercetin for the prevention and protection against testicular injury.

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