Plantas cardiotóxicas para ruminantes no Brasil

Nascimento, Naiara C. F.; Aires, Lorena D’Andrade; Pfister, James A.; Medeiros, Rosane M.T.; Riet-Correa, Franklin; Mendonça, Fábio de Souza

doi:10.1590/1678-5150-pvb-5548

Cited by 9 publications

(5 citation statements)

References 61 publications

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“…For cattle, poisoning by IAs must be differentiated from other toxic myopathies and cardiomyopathies, particularly those caused by cardiotoxic plants that cause severe regressive changes and cardiac fibrosis, such as Niedenzuella multiglandulosa, Niedenzuella acutifolia (Caldas et al 2011, Nascimento et al 2018, and Ateleia glazioveana (Barros 2016); by plants that cause muscle degeneration and necrosis, such as Senna occidentalis (Carmo et al 2011, Orlandini et al 2015 and Senna obtusifolia (Carvalho et al 2014); and nutritional myopathy (white muscle disease) caused by selenium and vitamin E deficiency (Barros et al 1988, Barros 2007. Although, to date, such diseases have not been described in buffaloes, no toxic plants of these genera have been found in pastures where buffaloes from Lot 1 were kept.…”

Section: Discussionmentioning

confidence: 99%

Accidental monensin poisoning in buffaloes in Bahia, Brazil

et al. 2022

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Monensin is an ionophore antibiotic (IA) widely used for growth promotion and weight gain in the production of ruminants. However, it has caused intoxication in several species, including buffaloes, mainly because of the ignorance or disrespect of the recommendations for use in each animal species. The objective of this study was to describe, for the first time, clinical-epidemiological and anatomopathological data of an outbreak of accidental poisoning by monensin in buffalos and rediscuss the recommendation of the use of IA in the production of this species. The outbreak affected 21 adult buffaloes after consumption of remains from a feed formulated on the farm and whose constituents were mixed by hand. Clinical and first death signs were observed 24 hours after ingestion of this food. In general, the clinical picture was characterized by muscle weakness, tremors, difficulty in locomotion, and decubitus. Fifteen buffaloes presented clinical signs of poisoning (71.5% morbidity), followed by death (100% lethality), after acute to subacute evolution (<24h to 96h). Laboratory tests indicated elevated serum activity of creatine phosphokinase and aspartate aminotransferase enzymes. Three buffaloes underwent necropsy, and samples from several organs were collected for histopathological examination. The main injuries found were hyaline degeneration and multifocal segmental necrosis in the skeletal and cardiac striated muscles (myopathy and degenerative-necrotic multifocal multifocal-necrotic cardiopathy). The diagnosis was confirmed by the toxicological evaluation of suspected ration remains, which detected 461.67mg/kg of monensin. The death of 71.5% buffaloes in this lot occurred due to a succession of errors, which included faults in the formulation of the ration and, above all, due to the use of monensin in a highly sensitive species. Despite the possible beneficial effects of IA use as a dietary supplement for buffaloes, we are of the opinion that IAs should never be used in bubalinoculture since any increment in production does not compensate for the imminent risk of death due to a small safety margin for this species and the absence of antidotes.

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Section: Discussionmentioning

confidence: 99%

Accidental monensin poisoning in buffaloes in Bahia, Brazil

et al. 2022

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“…rigida é um cipó arbustivo com folhas elípticas, opostas, sem pelos, inflorescência em cachos, axilar e terminal com flores pequenas e amarelas (TOKARNIA et al, 2000;D´OLIVEIRA et al, 2018b) O princípio tóxico da espécie deve-se à presença de monofluoroacetato em extratos foliares de M. rigida. A ação do monofluoroacetato, ou ácido monofluoracético, baseia-se na formação de fluorocitrato, seu metabólito ativo, que bloqueia competitivamente a aconitase e o ciclo de Krebs, reduzindo a produção de ATP e provocando distúrbios no coração e sistema nervoso central dos animais (NASCIMENTO et al, 2018).…”

Section: Mascagnia Rigida (A Juss) Grisebunclassified

Plantas Tóxicas a Bovinos: Análise Dos Processos De Dispersão E Regeneração Das Espécies

Ataíde¹,

Silva²,

Santos³

2019

Agrarian

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RESUMO A intoxicação por plantas é sabidamente uma das principais causas de morte de bovinos adultos no Brasil. As plantas tóxicas são caracterizadas como todos os vegetais que, introduzidos no organismo dos homens ou de animais domésticos, são capazes de causar danos à saúde e vitalidade desses seres. O presente estudo teve como objetivo pesquisar as principais plantas tóxicas potencialmente causadoras de enfermidades a bovinos, identificando os mecanismos de dispersão dessas espécies e propondo alternativas para minimizar os efeitos negativos aos animais. Foram descritas cinco espécies causadoras de danos a bovinos, quais sejam: Palicourea marcgravii, Mascagnia rigida, Tetrapterys acutifolia, Pteridium aquilinum e Cestrum laevigatum, abordando especialmente seus processos de dispersão e regeneração. Conclui-se que a compreensão da dispersão das sementes, aliada ao conhecimento das características de regeneração e propagação das plantas apresenta-se como uma ferramenta útil para a conservação/manutenção de áreas sem infestação por estas plantas. PALAVRAS-CHAVE: danos a bovinos, Intoxicação; propagação de plantas.

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“…Currently, there are 131 toxic plant species, divided into 79 genera, in Brazil. Among these, the group of toxic plants that cause exercise-related sudden death is represented by 22 species belonging to three families: Rubiaceae, Malpighiaceae, and Bignoniaceae (Nascimento et al 2018). The presence of sodium monofluoroacetate (MFA) as a toxic principle has already been confirmed in the following species: Palicourea marcgravii, Palicourea aeneofusca (Lee et al 2012) (Cook et al 2014, Carvalho et al 2016, Amorimia amazonica, Amorimia exotropica, Amorimia pubiflora, Amorimia rigida, Amorimia septentrionalis (Lee et al 2012), Niedenzuella stannea (Arruda et al 2017), and Tanaecium bilabiatum (formerly Arrabidaea bilabiata), misidentified as Fridericia japurensis (Arrabidaea japurensis) in the state of Roraima, Brazil (Lima et al 2016).…”

Section: Introductionmentioning

confidence: 99%

Techniques for prevention and control of poisoning by sodium monofluoroacetate (MFA)-containing plants in ruminants

2019

Self Cite

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Monofluoroacetate (MFA)-containing plants cause sudden death associated with exercise in ruminants, and are responsible for significant losses in Brazilian livestock, estimated at 500,000 bovine deaths annually. Most of the times, the control and treatment of this type of poisoning are not efficient, because disease evolution is superacute, usually causing the death of the animal. Due to the difficulty in controlling this intoxication, several studies have suggested alternatives to prevent it, mainly by making animals resistant to the MFA present in these plants or by avoiding their consumption. This literature review addresses the techniques used experimentally to control the poisoning of ruminants by plants containing MFA. The first studies carried out in Brazil demonstrated that goats and sheep that continuously receive non-toxic doses of plant containing MFA show greater resistance to poisoning than untreated animals, and that this resistance can be transmitted by ruminal fluid transfaunation, suggesting that poisoning occurs due to the presence of bacteria that hydrolyze MFA in the rumen. Based on this hypothesis, several MFA-hydrolyzing bacteria were isolated (Enterococcus faecalis, Bacillus sp., Paenibacillus sp., Burkholderia sp., Cupriavidus sp., Staphylococcus sp., Ancylobacter sp., Ralstonia sp., Stenotrophomonas sp., Pigmentiphaga kullae, and Ancylobacter dichloromethanicus). When some of these bacteria were administered intraruminally, they provided the animal with a different level of protection against poisoning. However, it was observed that protection is gradually lost when the bacterium administration is interrupted. Consequently, to obtain more efficient protection, these bacteria should be administered continuously, probably in the form of probiotics. In another assay, MFA was administered to sheep at non-toxic doses to test the hypothesis that this substance could induce the multiplication of bacteria that hydrolyze it in the rumen. There was no increase in resistance to poisoning after administration of MFA; however, no signs of poisoning were observed when animals received trifluoroacetate and no clinical signs were verified when they were challenged with toxic doses of MFA; in contrast, all control animals presented clinical signs. These results suggest that trifluoroacetate induces the proliferation of MFA-degrading bacteria, and can be used in intoxication prophylaxis. The conditioned food aversion technique, using lithium chloride, has been successfully used experimentally to prevent ruminants from ingesting plants that contain MFA. Another alternative tested was the spraying of Amorimia septentrionalis with the endophytic bacterium Herbaspirillum seropedicae, which degrades MFA, resulting in decreased concentration of this compound in the plants. In conclusion, several experimental techniques have been proved efficient in the control and prophylaxis of MFA-containing plant poisoning; however, none of these techniques are available commercially. Further experiments, mainly in the field, should be carried out to adapt some of these techniques to the conditions of extensive breeding in the numerous areas where MFA-containing plants occur.

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Plantas cardiotóxicas para ruminantes no Brasil

Cited by 9 publications

References 61 publications

Accidental monensin poisoning in buffaloes in Bahia, Brazil

Accidental monensin poisoning in buffaloes in Bahia, Brazil

Plantas Tóxicas a Bovinos: Análise Dos Processos De Dispersão E Regeneração Das Espécies

Techniques for prevention and control of poisoning by sodium monofluoroacetate (MFA)-containing plants in ruminants

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