Plants against Helicobacter pylori to combat resistance: An ethnopharmacological review

Baker, Doha Abou

doi:10.1016/j.btre.2020.e00470

Cited by 36 publications

(22 citation statements)

References 177 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Long before H. pylori infection was recognized as causing chronic gastritis and peptic ulcers in 1982 ( Marshall and Warren, 1984 ), natural products have been used by physicians and healers to combat these illnesses based on empirical knowledge ( Yesilada et al., 1997 ). Today, over 240 plant species have demonstrated anti- H. pylori activity ( Salehi et al., 2018 ; Baker, 2020 ). With the pressing need for novel therapeutic options to face the current antibiotic crisis, the scientific community’s interest in traditional medicine and the use of natural products as sources of novel antibacterial drugs have been reinforced ( Cheesman et al., 2017 ; Anand et al., 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Fighting the Antibiotic Crisis: Flavonoids as Promising Antibacterial Drugs Against Helicobacter pylori Infection

González

Casado

Lanas

2021

Front. Cell. Infect. Microbiol.

View full text Add to dashboard Cite

Over half of the world’s population is estimated to be infected with Helicobacter pylori. Chronic infection with this microbial class I carcinogen is considered the most important risk factor for developing gastric cancer. The increasing antimicrobial resistance to first-line antibiotics mainly causes the failure of current eradication therapies, inducing refractory infections. The alarming increase in multidrug resistance in H. pylori isolates worldwide is already beginning to limit the efficacy of existing treatments. Consequently, the World Health Organization (WHO) has included H. pylori in its list of “priority pathogens” for which new antibiotics are urgently needed. Novel strategies must be followed to fight this antibiotic crisis, including properly exploiting the proven therapeutic potential of medicinal plants and plant-derived phytochemicals. In this mini-review, we overview the impressive properties of naturally occurring flavonoids as effective antimicrobial agents against H. pylori, which support the use of these plant-derived bioactive compounds as promising drug candidates for inclusion in novel and personalized combinatory therapies against H. pylori infection.

show abstract

Section: Introductionmentioning

confidence: 99%

Fighting the Antibiotic Crisis: Flavonoids as Promising Antibacterial Drugs Against Helicobacter pylori Infection

González

Casado

Lanas

2021

Front. Cell. Infect. Microbiol.

View full text Add to dashboard Cite

show abstract

“…Statistically, it is estimated that there are 750,000 plant species on Earth, of which 1-10% are used as food and medicine by both humans and animals [1,2]. Medicinal plants display several pharmacological properties such as antioxidants [3], anti-diabetes [4], antibacterial [5], antiviral [6], anticancer [7], and anti-ulcer activities [8]. The medicinal value of these plants lies in a group of bioactive organic compounds (metabolites, secondary compounds) generally classified into alkaloids, saponins, flavonoids, tannins, glycosides, anthraquinones, steroids, and terpenoids and present at different quantities and qualities within the plants [9].…”

Section: Introductionmentioning

confidence: 99%

“…Successive petroleum ether extraction of Malva leaves has been reported to exhibit a counter-irritant effect on the rabbit's ear [15]. Due to these pharmacological activities of Malva species and others reported by Gasparetto and colleagues (2012), the interest in finding other pharmacological activities or confirming the traditional use of Malva species continues to grow given the large scale at which Malva species grow and the recent existing literature highlighting its effectiveness in treating diseases in Palestine and other parts of the world [5,8,11]. The present study was designed to assess the antimicrobial and antioxidant activities of the methanolic extracts from M. sylvestris leaves, and to determine the profile of the secondary and volatile compounds.…”

Section: Introductionmentioning

confidence: 99%

Antibacterial, Antioxidant and Phytochemical Screening of Palestinian Mallow, Malva Sylvestris L.

Dowek

Fallah

Basheer-Salimia³

et al. 2020

Int J Pharm Pharm Sci

View full text Add to dashboard Cite

Objective: To evaluate antibacterial, antioxidant activities, the existence of the major secondary metabolites, and volatile compounds in methanolic extracts from M. sylvestris leaves. Methods: Antibacterial activity was assessed using a well diffusion method. Antioxidant activity was assessed using ABTS●+and DPPH● free radical scavenging assays. Phytochemical screening for secondary metabolites and volatile compounds were done following standard techniques and gas chromatography-mass spectrometry (GC–MS). Results: Methanolic extracts exhibited moderate antibacterial activity compared with the positive control against the gram-negative Klebsiella pneumoniae and the gram-positive bacteria’s Staphylococcus aureus by 47.2 and with 47.1% respectively. The average percentage of scavenging was 97.82±0.05 and 79.49±0.4 for ABTS•+and DPPH●, correspondingly. Total phenols were quantitatively estimated and found to be 78.9±9.55 mg GAE/g. Phytochemical screening assays revealed the presence of a wide range of phytochemical groups such as alkaloids flavonoids, phenols, tannins, quinones, saponins, steroids, tannins, terpenoides with at least sixteen volatile compounds detected in the plant. Conclusion: The present study confirmed the antioxidant activity of the methanolic extract of M. sylvestris and the existence of is the volatile compounds (phytol), which mediate, even partially, the antioxidant and the claimed analgesic activity of the plant.

show abstract

“…However, myricetin and luteolin were found to exhibit stronger inhibitory activity than the positive control (14). It was reported that plant flavonoids may contribute to several antimicrobial mechanisms, such as inhibition of nucleic acid synthesis (by inhibiting helicase, gyrase, and topoisomerase activity), disruption of membrane function (by inhibiting efflux pumps, porins, fatty acid synthase, and peptidoglycan synthesis), inhibition of energy metabolism, quorum sensing and biofilm formation, and thereby attenuation of the pathogenicity (40). These isolated compounds in the present study may serve as the lead compounds for development of new antipathogenic agents, a critical requirement to counteract the antibiotic-resistant bacteria.…”

Section: Discussionmentioning

confidence: 99%

Antibacterial activity of Hibiscus rosa-sinensis L. red flower against antibiotic-resistant strains of Helicobacter pylori and identification of the flower constituents

Ngan

Tan

Hoàng

et al. 2021

Braz J Med Biol Res

View full text Add to dashboard Cite

Utilization of plant resources for treatment of Helicobacter pylori infections is one of the appealing approaches as rapid emergence of antibiotic-resistant strains is occurring throughout the world. Ethanol extract and its fractions from Hibiscus rosa-sinensis red flower were assessed for antibacterial and urease inhibitory activities towards forty-three clinical strains and two reference strains of H. pylori. The ethyl acetate fraction exhibited the most potent bacteriostatic activity with minimum inhibitory concentrations (MICs) of 0.2-0.25 mg/mL and minimum bactericidal concentrations (MBCs) of 1.25-1.5 mg/mL against all test strains, including forty-three strains resistant to one to four antibiotics, azithromycin (MICs, 8-256 mg/mL), erythromycin (MICs, 8-128 mg/mL), levofloxacin (MICs, 8-256 mg/mL), and/or metronidazole (MICs, 8-256 mg/mL). The fraction had similar antibacterial activities toward these test strains suggesting the preparation and the antibiotics do not have a common mechanism of anti-H. pylori activity. The fraction also had stronger effects on biofilm formation, morphological conversion, and urease activity of H. pylori than the other fractions and the ethanol extract. These flower preparations were non-toxic to three human cell lines, and nine compounds were also isolated and identified from the ethyl acetate fraction. In vivo research needs to be conducted to confirm the potential usefulness of H. rosa-sinensis flower and its constituents for effective prevention and treatment of H. pylori disease.

show abstract

Plants against Helicobacter pylori to combat resistance: An ethnopharmacological review

Cited by 36 publications

References 177 publications

Fighting the Antibiotic Crisis: Flavonoids as Promising Antibacterial Drugs Against Helicobacter pylori Infection

Fighting the Antibiotic Crisis: Flavonoids as Promising Antibacterial Drugs Against Helicobacter pylori Infection

Antibacterial, Antioxidant and Phytochemical Screening of Palestinian Mallow, Malva Sylvestris L.

Antibacterial activity of Hibiscus rosa-sinensis L. red flower against antibiotic-resistant strains of Helicobacter pylori and identification of the flower constituents

Contact Info

Product

Resources

About