Plants and Natural Products for the Treatment of Skin Hyperpigmentation – A Review

Kanlayavattanakul, Mayuree; Lourith, Nattaya

doi:10.1055/a-0583-0410

Cited by 54 publications

(35 citation statements)

References 72 publications

(149 reference statements)

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“…Accordingly, improvement of skin hydration following makeup removed using the pumpkin seed oil remover was obviously noted by the volunteers. In addition, a consecutive application of this developed natural makeup remover for everyday usage would enhance skin benefits of pumpkin seed oil's phytochemicals for instance skin hydration and delaying of skin aging (Alvarex and Rodríguez, ; Kanlayavattanakul and Lourith, , ), respectively.…”

Section: Resultsmentioning

confidence: 99%

In Vitro and In Vivo Removal Efficacies of a Formulated Pumpkin Seed Oil Makeup Remover

Setsiripakdee

Lourith

Kanlayavattanakul

2019

J Surfact & Detergents

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Pumpkin seed oil is well known for its health benefits due to its high content of fatty acid constituents and tocopherols. The removal efficacy of pumpkin seed oil was assessed using UV–Vis spectroscopy. The oil was able to remove 79.92 ± 0.07%, 41.02 ± 0.25%, and 23.54 ± 0.19% of foundation and liquid and pen eyeliners. A stable makeup remover was formulated using 5–15% pumpkin seed oil. Addition of pumpkin seed oil significantly (P < 0.001) enhanced removal ability of the base remover. The remover containing 5% pumpkin seed oil was able to remove 89.27 ± 0.02%, 67.72 ± 0.08%, and 41.25 ± 0.07% of foundation, liquid, and pen eyeliners, respectively, while those of the remover containing 10% pumpkin seed oil were 78.24 ± 0.02%, 66.88 ± 0.05%, and 38.43 ± 0.05%, and those of the remover containing 15% pumpkin seed oil were 84.41 ± 0.01%, 69.79 ± 0.12%, and 41.88 ± 0.04%, respectively. On the other hand, removal efficiencies of the benchmark were 91.20 ± 0.03%, 73.46 ± 0.10%, and 54.00 ± 0.07%, respectively. The removers containing pumpkin seed oil did not cause skin irritation as monitored by a single closed‐patch test in 10 female volunteers. The remover containing 5% pumpkin seed oil was further preference studied in 25 female volunteers in a comparison with the benchmark. The pumpkin seed oil remover gained a better overall preference over the benchmark (82.29 ± 4.17% and 80.20 ± 8.64%; P = 0.287). Of which, skin hydration of the developed bio‐oil remover was significantly (P < 0.001) satisfied.

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Section: Resultsmentioning

confidence: 99%

In Vitro and In Vivo Removal Efficacies of a Formulated Pumpkin Seed Oil Makeup Remover

Setsiripakdee

Lourith

Kanlayavattanakul

2019

J Surfact & Detergents

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“…Dermatological formulation, including active compounds of strictly natural origin, is designed to protect the skin from hyperpigmentation. The aim of using natural ingredients is to reduce skin hyperpigmentation without causing undesirable hypopigmentation and irritation in the skin [10].…”

Section: Natural Herbal-based Treatment For Hyperpigmentationmentioning

confidence: 99%

“…Active compounds isolated from different plants inhibit melanogenesis with no cytotoxicity by different mechanisms including inhibition of tyrosinase and other related protein expressions, inhibition of tyrosinase activity, inhibition of melanin dispersion and translocation, etc. [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

On the Intricacies of Facial Hyperpigmentation and the Use of Herbal Ingredients as a Boon for Its Treatment: Cosmeceutical Significance, Current Challenges and Future Perspectives

Parveen¹,

Ali²,

Ali³

2019

Depigmentation

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Facial hyperpigmentation is the term used to express areas on irregular pigmentation in the skin. It appears as darkened patches on the face that make the facial skin look uneven. Facial hyperpigmentation is not physically debilitating but has been associated with enhanced psychosocial complications including anger, depression and frustration. These psychosocial burdens, in turn, have inference on quality of life and self-esteem. So, the treatment of facial hyperpigmentation seems to be a growing concern to the dermatologists today and they have been practising several treatment modalities including chemical peeling, laser therapy, dermabrasion, etc. But, those are found to be associated with various after-effects. Hence, the use of plants and its products is highly recommended as they are reported with either none or fewer after-effects. The present chapter draws attention to the forms of facial hyperpigmentation with their aetiologies and available treatment options for them with associated side effects. Furthermore, we have discussed about the other side of treatment with herbal ingredients which are safe and have less or no side effects. This chapter will be of value to the dermatologists who are searching for naturally derived ingredients for treating facial hyperpigmentation, in line with consumer expectations and preferences.

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“…Melanocytes play an essential role in defending the skin against UV light and free radicals [4,5]. In addition, microphthalmia-associated transcription factor (MITF) is a main factor controlling the transcription of enzymes such as tyrosinase [6]. Tyrosinase is transcriptionally regulated by MITF, which plays an essential role in melanin synthesis signaling [7,8].…”

Section: Introductionmentioning

confidence: 99%

Skin Improvement Effects of Gardeniae fructus Extract in HaCaT Keratinocytes, B16F10 Melanocytes, and CCD-986sk Fibroblast Cells

Hong

Lee

et al. 2019

Cosmetics

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The development of functional cosmetics with skin improvement effects from natural sources is necessary. In this study, the antioxidant, antiwrinkling, moisturizing, and whitening effects of Gardeniae fructus extract (GF) were investigated in keratinocytes, melanocytes, and fibroblast cells. Antioxidant activity was determined by a DPPH free radical scavenging assay. MMP-1, MMP-9, HAS1, and filaggrin mRNA levels were measured by RT-PCR in keratinocytes and fibroblast cells. MITF and tyrosinase protein levels were evaluated by blotting analysis in melanocytes. DPPH free radical activity was investigated to determine whether GF showed dose-dependent inhibitory activity. GF induced the upregulation of HAS1 and filaggrin mRNA expression in keratinocytes and fibroblast cells. GF led to the downregulation of MMP mRNA levels in keratinocytes and fibroblast cells. Western blotting was performed to confirm the whitening-related protein (MITF and tyrosinase) levels induced by GF in melanocytes, and the inhibitory activity was superior to that of the α-MSH used for the comparison test. GF showed marked antioxidant, antiwrinkling, skin moisturizing, and whitening activity in keratinocytes, melanocytes, and fibroblast cells. Through the results of these experiments, the applicability of GF as a natural and functional cosmetic material was verified.

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Plants and Natural Products for the Treatment of Skin Hyperpigmentation – A Review

Cited by 54 publications

References 72 publications

In Vitro and In Vivo Removal Efficacies of a Formulated Pumpkin Seed Oil Makeup Remover

In Vitro and In Vivo Removal Efficacies of a Formulated Pumpkin Seed Oil Makeup Remover

On the Intricacies of Facial Hyperpigmentation and the Use of Herbal Ingredients as a Boon for Its Treatment: Cosmeceutical Significance, Current Challenges and Future Perspectives

Skin Improvement Effects of Gardeniae fructus Extract in HaCaT Keratinocytes, B16F10 Melanocytes, and CCD-986sk Fibroblast Cells

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