Plants buffer some of the effects of a pair of cadmium-exposed zebrafish on the un-exposed majority

Shelton, Delia S.; Suriyampola, Piyumika S.; Dinges, Zoe M.; Glaholt, Stephen P.; Shaw, Joseph R.; Martins, Emília P.

doi:10.1016/j.etap.2024.104419

Cited by 2 publications

(2 citation statements)

References 107 publications

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“…Zebra sh serve as a well-established model for investigating how environmental pollutants, including metals, impact development, morphology and cardiovascular system in the lab (Chen et al, 2021;Shelton et al, 2023Shelton et al, , 2024Staudt & Stainier, 2012). Field studies of zebra sh help us ground our metrics ethologically (Kelly et al, 2021;Shelton et al, 2020;Suriyampola et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

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Therapeutic Efficacy of Selenium Pre-treatment in Mitigating Cadmium-Induced Cardiotoxicity in Zebrafish (Danio rerio)

Heuer,

Falagan-Lotsch,

Okutsu

et al. 2024

Preprint

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Cardiovascular diseases are a rampant public health threat. Environmental contaminants, such as Cadmium (Cd), a toxic metal, have been linked to increased risk for cardiovascular diseases. Given that human exposure to Cd is increasing overtime, there is a need to develop new therapies to ameliorate Cd toxicity. Selenium (Se), an essential trace element, has been proposed to rescue the effects of Cd toxicity, with mixed effects. Se's narrow therapeutic window necessitates precise dosing to avoid toxicity. Here, we assessed the effects of various waterborne Cd and Se concentrations and sequences on cardiac function using zebrafish (Danio rerio). We showed that Cd induced pericardial edemas and modified heart rates in a concentration-dependent manner. To identify the therapeutic range of Se for Cd-induced cardiotoxicity, zebrafish embryos were treated with 0, 10, 50, 100, 150, or 200 μg/L Se for 1-4 days prior to exposure to Cd at 2.5, and 5 μg/L. We found that a 50 µg/L Se pre-treatment prior to Cd at 2.5 μg/L, but not at 5 μg/L, reduced the prevalence of pericardial edemas and ameliorated Cd-induced bradycardia in zebrafish. Embryos exposed to 10 and 50 μg/L of Se showed typical heart morphology, whereas other Se-exposed and Se-deficient fish presented pericardial edemas. Longer Se pre-treatment durations led to fewer incidences of pericardial edemas. Overall, this study highlights the importance of optimizing Se concentration and pre-treatment periods to harness its protective effects against Cd-induced cardiotoxicity. These findings provide insights into potential therapeutic strategies for reducing Cd-related cardiovascular damage in humans.

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Section: Introductionmentioning

confidence: 99%

“…Cd is known to cause a wide array of impacts in larval and adult zebra sh (Avallone et al, 2015;Shelton et al, 2023Shelton et al, , 2024Wold et al, 2017). Impairments to the cardiovascular system vary across studies and are both concentration-and life-stage speci c. Liu, Zhao, et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Therapeutic Efficacy of Selenium Pre-treatment in Mitigating Cadmium-Induced Cardiotoxicity in Zebrafish (Danio rerio)

Heuer,

Falagan-Lotsch,

Okutsu

et al. 2024

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

Therapeutic Efficacy of Selenium Pre-treatment in Mitigating Cadmium-Induced Cardiotoxicity in Zebrafish (Danio rerio)

Heuer,

Falagan-Lotsch,

Okutsu

et al. 2024

Cardiovasc Toxicol

View full text Add to dashboard Cite

Cardiovascular diseases are a rampant public health threat. Environmental contaminants, such as Cadmium (Cd), a toxic metal, are risk factors for cardiovascular diseases. Given that human exposure to Cd is increasing, there is a need for therapies to ameliorate Cd toxicity. Selenium (Se), an essential trace element, has been proposed to rescue the effects of Cd toxicity, with mixed effects. Se's narrow therapeutic window necessitates precise dosing to avoid toxicity. Here, we assessed the effects of various waterborne Cd and Se concentrations and sequences on cardiac function using zebrafish (Danio rerio). We showed that Cd induced pericardial edemas and modified heart rates in zebrafish larvae in a concentration-dependent manner. To identify the therapeutic range of Se for Cd-induced cardiotoxicity, zebrafish embryos were treated with 0, 10, 50, 100, 150, or 200 μg/L Se for 1–4 days prior to exposure to 2.5 and 5 μg/L Cd. We found that a 50 µg/L Se pre-treatment before 2.5 μg/L Cd, but not 5 μg/L Cd, reduced the prevalence of pericardial edemas and ameliorated Cd-induced bradycardia in zebrafish. Zebrafish exposed to 10 and 50 μg/L of Se for up to 4 days showed typical heart morphology, whereas other Se-exposed and control fish presented pericardial edemas. Longer Se pre-treatment durations led to fewer incidences of pericardial edemas. Overall, this study highlights the importance of optimizing Se concentrations and pre-treatment periods to harness its protective effects against Cd-induced cardiotoxicity. These findings provide insights into potential therapeutic strategies for reducing Cd-related cardiovascular damage in humans. Graphical Abstract

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Plants buffer some of the effects of a pair of cadmium-exposed zebrafish on the un-exposed majority

Cited by 2 publications

References 107 publications

Therapeutic Efficacy of Selenium Pre-treatment in Mitigating Cadmium-Induced Cardiotoxicity in Zebrafish (Danio rerio)

Therapeutic Efficacy of Selenium Pre-treatment in Mitigating Cadmium-Induced Cardiotoxicity in Zebrafish (Danio rerio)

Therapeutic Efficacy of Selenium Pre-treatment in Mitigating Cadmium-Induced Cardiotoxicity in Zebrafish (Danio rerio)

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