Plants for male fertility regulation

Kamal, Raka; Gupta, Radhey S.; Lohiya, N. K.

doi:10.1002/ptr.1320

Cited by 41 publications

(25 citation statements)

References 71 publications

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“…The roots of Aristolochia indica and Plumbago zeylanica; the leaves of Azadirachta indica, Catharanthus roseus, Vinca rosea and Ocimum sanctum; the flowers of Hibiscus rosa-sinensis and Malvaviscus conzatii; the seeds of C. papaya and Vitex negundo; and the fruit of Momordica charantia have been identified as candidates for male fertility regulation. Reduction in weight of the testis, epididymis, seminal vesicle and ventral prostate; suppression of spermatogenesis; degeneration of epididymal epithelium; and regression or absence of secretory activity of the seminal vesicle and ventral prostate are some of the common outcomes of the use of these plants, as well as several hundred plants undergoing preliminary screening for antifertility activity [27][28][29].…”

Section: Discussionmentioning

confidence: 99%

Sperm characteristics and ultrastructure of testes of rats after long-term treatment with the methanol subfraction of Carica papaya seeds

Manivannan

Mittal²,

Goyal³

et al. 2009

Asian J Androl

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The contraceptive efficacy of Carica papaya seeds after short-term evaluation has been well established. We have examined the safety and mechanism of contraception in rats after long-term treatment with the methanol subfraction (MSF) of C. papaya seeds. The test substance was administered orally to the male albino rats (n = 40) at 50 mg per kg body weight each day for 360 days. Control animals (n = 40) received olive oil as a vehicle. Recovery was assessed up to 120 days after treatment withdrawal. Sperm parameters, serum testosterone levels, fertility, histology and ultrastructure of the testis, haematology and serum clinical chemistry were evaluated to establish the safety and efficacy of the test substance. Safety of long-term treatment was evidenced by unaltered health status, organ weight, haematology and clinical chemistry, and by an increase in body weight. The mechanism of contraception was shown by reduction in nuclear and cytoplasmic volume, normal nuclear characteristics and vacuolization in the cytoplasmic organelles of the Sertoli cells, as well as nuclear degeneration in spermatocytes and spermatids indicating disturbed spermatogenesis. Leydig cells were normal. Initial effects were observed in Sertoli cells at 60 days of treatment. Spermatocytes and spermatids were affected after 120-240 days of treatment. A significant decline in sperm count and viability, total inhibition of sperm motility, increased numbers of sperm abnormalities, normal serum testosterone levels and 100% sterility were evident after 60 days of treatment. All the altered parameters, including percent fertility, were restored to control level 120 days after treatment withdrawal. It is concluded that the MSF is safe for long-term treatment and the mechanism of contraception is shown by its effect on spermatid differentiation in the testis, possibly mediated by the Sertoli cell factors.

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Section: Discussionmentioning

confidence: 99%

Sperm characteristics and ultrastructure of testes of rats after long-term treatment with the methanol subfraction of Carica papaya seeds

Manivannan

Mittal²,

Goyal³

et al. 2009

Asian J Androl

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“…Andrographis paniculata possessed antifertility and pregnancy-terminating effects 85) and stopped spermatogenesis in male rats. 86) None of the female mice that daily consumed Andrographis paniculata mixed food became pregnant when mated with the male of potential fertility who did not receive the treatment.…”

Section: Anti-fertility Activitymentioning

confidence: 95%

Pharmacological Aspects of Andrographis paniculata on Health and Its Major Diterpenoid Constituent Andrographolide

Jarukamjorn

Nemoto

2008

JOURNAL OF HEALTH SCIENCE

201

111

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Nowadays, research on medicinal plants has attracted a lot of attention globally. A number of evidence has been accumulated to demonstrate promising potential of medicinal plants used in various traditional, complementary, and alternative systems. In recent years, a medicinal plant, Andrographis paniculata, and its major active phytochemicals have been extensively studied for several pharmacological activities. To understand the mechanism of action, researches have to be carried out at molecular levels. The present review aims at compiling consequential compendium of pharmacological benefits of health on this plant and its major diterpenoid constituent andrographolide that have been tested in various experimental models using modern scientific methodologies.

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“…But application of all of these compounds has been seriously questioned owing to various hazards as they were proved toxic or idiosyncratic on both the short as well as long term use in the reproductive organs. 4 However, use of extracts of medicinal plants is commonly associated with low or negligible toxic effect on short term use on the reproductive organs. Moreover, long term use associated effects may still be under estimated.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of contact spermicidal potential of Lantana camara leaf extracts on human spermatozooa

Bhatia

Singh

Shorey

et al. 2016

Int J Reprod Contracept Obstet Gynecol

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Plants for male fertility regulation

Cited by 41 publications

References 71 publications

Sperm characteristics and ultrastructure of testes of rats after long-term treatment with the methanol subfraction of Carica papaya seeds

Sperm characteristics and ultrastructure of testes of rats after long-term treatment with the methanol subfraction of Carica papaya seeds

Pharmacological Aspects of Andrographis paniculata on Health and Its Major Diterpenoid Constituent Andrographolide

Evaluation of contact spermicidal potential of Lantana camara leaf extracts on human spermatozooa

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