Plants traditionally used in age related brain disorders—A survey of ethnobotanical literature

Adams, Michael; Gmünder, Francine; Hamburger, Matthias

doi:10.1016/j.jep.2007.07.016

Cited by 279 publications

(159 citation statements)

References 77 publications

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“…Q4T is the time spent in target quadrant to search the hidden platform, served as index for retrieval of memory. [25] In our study, there was a gradual and definite decreasing trend in ELT starting from day 1 through day 2, day 3 up to day 4 in all mice. When the day 4 ELTs in all the drug-treated groups as well as in the vehicle-treated groups were compared with their corresponding day 1 values, the differences were significant.…”

Section: Discussionsupporting

confidence: 60%

Statins: Are they also memory enhancers? A study in relation to their hypocholesterolemic and antioxidant effects in Swiss albino mice

Mishra¹,

Nayak²,

Sarangi³

2017

Natl J Physiol Pharm Pharmacol

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Background:The most common cause of dementia with progressive loss of memory is Alzheimer's disease (AD), a neurodegenerative disorder that occurs due to increased oxidative stress, deposition of amyloid protein, and loss of cholinergic neurons. Statins, by their hypocholesterolemic, antioxidant, and other activities may be helpful in this regard. Aims and Objectives: The aim of this study is to examine the relation between memory restoring effect, lipid lowering effect as well as the antioxidant properties of statins in experimental dementia models using Swiss albino mice. Materials and Methods: Cognitive ability was tested in randomly selected young Swiss albino mice with two exteroceptive behavioral models, passive avoidance paradigm, and Morris Water Maze (MWM) by assigning 30 animals divided equally into 5 groups for each model. Amnesia was induced by feeding high-fat-diet for 90 days in 4 groups of mice. The 5 th group served as control with young mice. Piracetam, atorvastatin, and simvastatin were given, respectively, to 3 of the amnesic groups of each model whereas the 4 th group treated with vehicle served as positive control. Results:Step-down latency was significantly higher in young mice as well as amnesic mice treated with piracetam, simvastatin, or atorvastatin in comparison to vehicle-treated amnesic mice. Similar result was also seen during retrieval test in MWM, although all the groups performed comparably during acquisition trial. Brain malondialdehyde (MDA) levels were significantly low in all the groups who performed well in either of the exteroceptive behavioral models. Cholesetrol levels in young control and statin-treated groups were significantly low in comparison to piracetam-or vehicle-treated mice. Conclusions: Atorvastatin and simvastatin improved the cognitive ability in terms of learning as well as retrieval of learned experience which may be attributed to their hypocholesterolemic and antioxidant properties.

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Section: Discussionsupporting

confidence: 60%

Statins: Are they also memory enhancers? A study in relation to their hypocholesterolemic and antioxidant effects in Swiss albino mice

Mishra¹,

Nayak²,

Sarangi³

2017

Natl J Physiol Pharm Pharmacol

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“…Polyporaceae) is a saprophytic fungus, which is used in Korea as well as other East Asian countries to treat age-related brain disorders, and to improve cognitive and memory function in old age [94]. It's sclerotium, commonly known as "Hoelen", contains several monosaccharides, triterpene derivatives, and 15 amino acids [95,96].…”

Section: Miscellaneous Tkm Plantsmentioning

confidence: 99%

Traditional Korean East Asian Medicines and Herbal Formulations for Cognitive Impairment

Kumar

Song

et al. 2013

Molecules

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Abstract:Hanbang, the Traditional Korean Medicine (TKM), is an inseparable component of Korean culture both within the country, and further afield. Korean traditional herbs have been used medicinally to treat sickness and injury for thousands of years. Oriental medicine reflects our ancestor's wisdom and experience, and as the elderly population in Korea is rapidly increasing, so is the importance of their health problems. The proportion of the population who are over 65 years of age is expected to increase to 24.3% by 2031. Cognitive impairment is common with increasing age, and efforts are made to retain and restore the cognition ability of the elderly. Herbal materials have been considered for this purpose because of their low adverse effects and their cognitive-enhancing or anti-dementia activities. Herbal materials are reported to contain several active compounds that have effects on cognitive function. Here, we enumerate evidence linking TKMs which have shown benefits in memory improvements. Moreover, we have also listed Korean herbal formulations which have been the subject of scientific reports relating to memory improvement.

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“…Antes que ocorra nova liberação de acetilcolina, a molécula previamente liberada deve ser hidrolisada pela AChE. Na doença de Alzheimer (DA), complexa e progressiva doença neurodegenerativa multifatorial, atingindo primordialmente a população idosa com mais de 65 anos de idade (Adams et al, 2007) são observados déficits cognitivos e funcionais. Evidências demonstram que esses déficits relacionam-se com a degeneração do sistema colinérgico, devido principalmente a diminuição dos níveis plasmáticos de acetilcolina (Vinutha et al, 2007).…”

Section: Introductionunclassified

Avaliação da inibição da acetilcolinesterase por extratos de plantas medicinais

Mota

Barros

Cunha

et al. 2012

Rev. bras. plantas med.

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Palavras-chave: extrato aquoso, extrato etanólico, inibição enzimática ABSTRACT: Evaluation of acetylcholinesterase inhibition by extracts from medicinal plants.In this study, we evaluated the inhibitory activity against acetylcholinesterase (AChE) according to Ellman's method, modified by Rhee, for ethanol and aqueous extracts from eight plants used in folk medicine in the northeast region of Brazil. E. velutina aqueous extract did not have inhibitory activity, while Maytenus rigida aqueous extract showed low inhibitory activity (percentage of inhibition of 4%). Moderate inhibitory activity was detected for Phoradendron piperoides aqueous extract (percentage of inhibition of 40%), while V. agnus castus L. extract inhibited 74% AChE activity, characterized as a potent inhibitory activity. Evaluation of AChE inhibition by ethanol extracts indicated that the extracts from Sideroxylon obtusifolium, Erythrina velutina, Vitex agnus-castus L., Phoradendron piperoides, Chrysobalanus icaco, Bauhinia cheilantha and Orbignya phalerata did not show inhibitory activity. A low inhibitory activity was observed for ethanol extracts from Maytenus rigida (percentage of inhibition of 7%) and Hyptis fruticosa (percentage of inhibition of 11%). Moringa oleifera ethanol extract showed moderate inhibitory activity, inhibiting 47% of the activity of this enzyme. None of the tested ethanol extracts showed potent inhibitory activity against AChE. Results of the studies of acetylcholinesterase inhibition allow the conclusion that V. agnus-castus L. aqueous extract showed to be most effective in inhibiting AChE. This result reinforces the need for continued study of this extract in order to make the partition and the purification of fractions to isolate the molecule responsible for the observed inhibition.

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Plants traditionally used in age related brain disorders—A survey of ethnobotanical literature

Cited by 279 publications

References 77 publications

Statins: Are they also memory enhancers? A study in relation to their hypocholesterolemic and antioxidant effects in Swiss albino mice

Statins: Are they also memory enhancers? A study in relation to their hypocholesterolemic and antioxidant effects in Swiss albino mice

Traditional Korean East Asian Medicines and Herbal Formulations for Cognitive Impairment

Avaliação da inibição da acetilcolinesterase por extratos de plantas medicinais

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