Plants used for the management of venereal diseases in sub-Saharan Africa: a systematic review and critical assessment of their research status

Abstract

Background Sub-Saharan Africa faces one of the highest burdens of venereal diseases (VDs) globally. This review aims to critically evaluate the existing literature on the diverse Indigenous knowledge and medicinal plants utilised for treating VDs in sub-Saharan Africa. Methods We used the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) protocol to guide the execution of the review. Relevant papers from scientific databases and search engines were assessed. The inclusion criteria included literature published from 2008 and May 16, 2024, and assessment of specific predetermined VDs. Medicinal plants based on certain ethnobotanical indices and data were recorded from each literature. Results Among the 131 studies included in this review, a total of 20 relevant ethnobotanical reports were identified, with Nigeria and South Africa having the highest contributions (25% each). A high diversity and richness of 445 ethnobotanically valued anti-venereal plants (99 families) from over 872 Indigenous knowledge holders were inventoried. Plants with the highest diversity of use in traditional treatment of VDs are Cassia abbreviata, Ziziphus mucronata, Ximenia caffra, Catharanthus roseus, and Terminalia prunioides. The most represented families are Fabaceae (15.8%), Cucurbitaceae (5.9%), Solanaceae (5.9%), Euphorbiaceae (5%), and Combretaceae (5%). Roots and leaves were highly utilised with frequencies of 41.5% and 26.3%, respectively. The most used method of preparation are decoctions (36.7%) and infusions (12.2%), whereas oral route (72.9%) dominated the mode of administration of the medicinal plants. Conclusions This review consolidated data from sub-Saharan Africa—notwithstanding a limited number of studies in quantitative synthesis—and identified a diverse array of ethnobotanically valued anti-venereal plants, enabling meaningful conclusions to be drawn for future ethnopharmacological assessments. Effective plant conservation and advancement of ethnobotanical research in the region require stringent regulations and cross-country collaborations.