2019
DOI: 10.1016/j.numecd.2019.08.009
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Plaque calcification is driven by different mechanisms of mineralization associated with specific cardiovascular risk factors

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Cited by 26 publications
(23 citation statements)
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“…Recently, many clinicpathological studies contributed to consider calcification as an active process correlated with the evolutive status of the atheromatous plaque [2,[5][6][7]. From molecular point of view, some studies suggested that mineralization processes occurred in coronaries were similar to those involved in bone formation [8][9][10][11][12]. Nevertheless, molecular mechanisms Int.…”
Section: Introductionmentioning
confidence: 99%
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“…Recently, many clinicpathological studies contributed to consider calcification as an active process correlated with the evolutive status of the atheromatous plaque [2,[5][6][7]. From molecular point of view, some studies suggested that mineralization processes occurred in coronaries were similar to those involved in bone formation [8][9][10][11][12]. Nevertheless, molecular mechanisms Int.…”
Section: Introductionmentioning
confidence: 99%
“…Among the most recognized processes involved in calcium apposition in atheromatous plaque there are death of smooth muscle cells (SMCs) and inflammatory cells, agglomeration of calcium-filled extracellular matrix vesicles, and decrease of mineralization inhibitors [8,9]. However, none of these mechanisms seems to be related to a specific morphological aspect of atheromatic plaques [13][14][15][16][17].…”
Section: Introductionmentioning
confidence: 99%
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“…Despite it is known that the cardiovascular risk factors certainly favor the development and growth of atherosclerotic plaque, it is not yet fully understood exactly which in particular favor its destabilization by accelerating plaque growth with consequent rupture and thrombosis [15][16][17]. It is possible to hypothesize that the main cardiovascular risk factors can play a crucial role in the destabilization process of atheromatous lesions through the modification of the histological composition of fibroatheromatous plaques.…”
Section: Introductionmentioning
confidence: 99%