Plaque contact surface area and lumen volume predict stroke risk in extracranial carotid artery stenosis

Gedney, Ryan; Kung, Ethan; Mehta, Veena; Brown, Adam; Bridges, Matthew; Veeraswamy, Ravi K.

doi:10.1016/j.jvs.2022.03.008

Cited by 4 publications

(1 citation statement)

References 10 publications

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“…Previous studies suggested that the stenosis degree of the vascular lumen is the main factor associated with therapeutic strategy and patients’ prognosis. 3 , 4 However, increasing evidence suggested that missed diagnoses caused by asymptomatic features and complications induced by plaque instability are adverse prognostic factors. 5 – 7 There is an urgent need for exploring effective biomarkers associated with the occurrence and development of CAS, especially the stability of plaque.…”

Section: Introductionmentioning

confidence: 99%

lncRNA PCA3 Suppressed Carotid Artery Stenosis and Vascular Smooth Muscle Cell Function via Negatively Modulating the miR-124-3p/ITGB1 Axis

Qiang

2023

Clin Appl Thromb Hemost

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Background & objectives Due to the hidden pathogen, carotid artery stenosis (CAS) always occurred at an advanced stage leading to serious sequelae and even deaths. The significance of long noncoding RNA (lncRNA) prostate cancer antigen 3 (PCA3) in CAS incidence and progression were evaluated aiming to explore a potential target for its therapy. Materials and methods Serum samples were collected from 83 asymptomatic CAS patients and 52 healthy individuals and PCA3 was compared using polymerase chain reaction (PCR). The PCA3 levels were compared between stable and unstable plaque in CAS patients. The effect of PCA3 on vascular smooth muscle cells (VSMCs) proliferation and motility was assessed by CCK8 and transwell assay. Results PCA3 was downregulated in CAS patients and their unstable plaque tissues compared with healthy individuals and stable plaque, respectively. Reduced PCA3 could discriminate CAS patients with relatively high sensitivity and specificity and were associated with higher total cholesterol level and stenosis degree, unstable plaque, and complications. PCA3 downregulation predicted the adverse outcomes of CAS patients. In VSMCs, overexpressing PCA3 significantly suppressed cell proliferation, migration, and invasion, which was alleviated by miR-124-3p/ITGB1 axis. Conclusion PCA3 served as a biomarker of CAS and regulates the function of VSMCs through sponging miR-124-3p/ITGB1 and indirectly influence the stability of plaque.

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Section: Introductionmentioning

confidence: 99%

lncRNA PCA3 Suppressed Carotid Artery Stenosis and Vascular Smooth Muscle Cell Function via Negatively Modulating the miR-124-3p/ITGB1 Axis

Qiang

2023

Clin Appl Thromb Hemost

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3-D Contrast-Enhanced Fusion Ultrasound for Accurate Volume Assessment of Vessel Lumen and Plaque in Carotid Artery Disease as Compared With Computed Tomography Angiography

Yeung,

Eiberg,

Collet-Billon

et al. 2024

Ultrasound in Medicine & Biology

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Carotid plaque volume measurement in ischemic stroke: A pilot study

Koshy,

Ramakrishnan

et al. 2024

JNRP

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Objectives: Carotid atherosclerosis is a significant risk factor for acute ischemic stroke. Three-dimensional (3D) sonography is a new technique that can be used to analyze carotid plaque both quantitatively and qualitatively. The aim was to study carotid atherosclerosis in stroke patients and healthy controls in terms of plaque volume quantification by 3D ultrasound (US). Materials and Methods: An observational descriptive study was conducted in the stroke unit of a university referral hospital in South India. Patients with ischemic stroke between the ages of 20 and 70 years were studied, along with age- and sex-matched controls. Carotid sonography (2D and 3D) along with Doppler studies was done in all patients, using Philips Affiniti 50 US system. Vascular plaque quantification software was used to assess plaque volume. Results: Twenty-four subjects were recruited, and two were excluded from the study. Twelve were cases, and ten were controls. The mean carotid intima-media thickness (CIMT) (average CIMT in six sites in common carotid artery, three on each side) studied in patients was 0.65 ± 0.10 mm, while that for healthy subjects was 0.62 ± 0.06 mm. The mean plaque volume in patients with stroke or transient ischemic attack was 179.82 ± 310.3 mm3, and that in healthy subjects was 56.75 ± 69.6 mm3. Plaque heterogeneity, surface irregularity, and ulceration were found to be common in symptomatic carotid plaques. Conclusion: The 3D sonography is a non-invasive and simple feasible tool for the analysis of carotid plaque.

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Plaque contact surface area and lumen volume predict stroke risk in extracranial carotid artery stenosis

Cited by 4 publications

References 10 publications

lncRNA PCA3 Suppressed Carotid Artery Stenosis and Vascular Smooth Muscle Cell Function via Negatively Modulating the miR-124-3p/ITGB1 Axis

lncRNA PCA3 Suppressed Carotid Artery Stenosis and Vascular Smooth Muscle Cell Function via Negatively Modulating the miR-124-3p/ITGB1 Axis

3-D Contrast-Enhanced Fusion Ultrasound for Accurate Volume Assessment of Vessel Lumen and Plaque in Carotid Artery Disease as Compared With Computed Tomography Angiography

Carotid plaque volume measurement in ischemic stroke: A pilot study

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