Plaque‐Like Myofibroblastic Tumor of Infancy: A New Case Report and Literature Review

Abstract

Plaque-like myofibroblastic tumor of infancy is a rare entity, with only a few reports described in the literature. Herein we present a new case of a nodular plaque-like lesion of the left lower back in an 18-month-old boy. The lesion might initially be thought to be a dermatofibroma, but the overall characteristics suggested the diagnosis of plaque-like myofibroblastic tumor of infancy. We also provide a summary of previous reports in the literature about this exceptional tumor.

Plaque‐like myofibroblastic tumor, a rare entity of childhood: Possible pitfalls in differential diagnosis

“…The diagnosis is allowed by clinical findings, histopathology, and immunohistochemistry; radiological imaging can provide additional clues. Magnetic resonance imaging of some previous cases excluded muscular, bone, and visceral involvements . When the diagnosis of PLMT is achieved, a complete surgical excision of the lesion is curative, with no need for other therapies …”

“…The etiology of PLMT is unclear . The diagnosis is allowed by clinical findings, histopathology, and immunohistochemistry; radiological imaging can provide additional clues.…”

“…A peculiar variant of DF, more similar to PLMT, is represented by multiple clustered DFs (MCD) . MCD appears as multiple 0.5 to 1 cm reddish brown papules clustered in one anatomical area larger than 5 cm, that usually merge into one plaque or are arranged in a linear pattern.…”

“…DFSP is rarely congenital and occasionally presents as an atrophic plaque . Histological examination is characterized by densely packed spindle cells arranged in a storiform pattern and infiltrating the subcutis …”

“…It has been hypothesized that PLMT and MCD may be considered as part of a same disease spectrum because of the overlapping clinical, histological and immunohistochemical features between them.…”