Plaque radiotherapy for retinoblastoma Long-term tumor control and treatment complications in 208 tumors

Radiotherapy for ocular tumours

“…The usual dose with I-125 is 40 Gy delivered in 4-5 days to the apex of the tumour with excellent local control rates of around 90%. 17 An anterior inactive extension to custom-built plaques facilitates the positioning for tumours in the posterior pole of the eye (Figure 9). 18 The dose used with Ru-106 plaques in Essen is 80 Gy to the apex, although most tumours responded with a dose of at least 50 Gy.…”

Diagnosis and Management of Retinoblastoma

“…Plaque radiotherapy can be used as a primary or secondary treatment. 54,55 In fact, in 70% of cases,plaque radiotherapy is used as a secondary treatment to salvage a globe after prior failed treatment, usually failed external beam radiotherapy or chemotherapy. 54 Overall, using Kaplan-Meier estimates, there is approximately an 80% tumor control rate at 4 years with one application of plaque radiotherapy.…”

Malignant transformation surrounding iodine-125 beads after treatment of a low grade glioma.

“…Side-effects included radiation urethritis, rectal irritation and bleeding [1]. Iodine-125 brachytherapy is also commonly used for intraocular neoplasms [2]. It provides impressive ocular tumour control rates [2].…”

“…Iodine-125 brachytherapy is also commonly used for intraocular neoplasms [2]. It provides impressive ocular tumour control rates [2]. Whilst ocular side-effects are common, such as retinopathy, papilloedema and cataracts, there was rarity of associated secondary cancers [2].…”

“…It provides impressive ocular tumour control rates [2]. Whilst ocular side-effects are common, such as retinopathy, papilloedema and cataracts, there was rarity of associated secondary cancers [2]. These implants have also found a role in reducing the incidence of local recurrences and prolonging survival in non-small cell lung cancer [3].…”