Plaque stabilisation by systemic and local drug administration

Spratt, James C.; Camenzind, Edoardo

doi:10.1136/hrt.2004.034975

Cited by 7 publications

(14 citation statements)

References 34 publications

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“…For this, the structure adopted by Lau et al in [1] and Spratt et al in [2] will be followed closely while relying heavily on a few relevant articles [3][4][5] (along with the two previously mentioned articles) for content. After building the case for local drug delivery systems as a viable option for treating vulnerable plaques, the motivation for the proposed work will be presented by outlining potential application and significance of the computational tool developed.…”

Section: Background and Significancementioning

confidence: 99%

Mathematical modeling of coupled drug and drug-encapsulated nanoparticle transport in patient-specific coronary artery walls

Hossain

Hossainy²,

Bazilevs

et al. 2011

Comput Mech

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Section: Background and Significancementioning

confidence: 99%

Mathematical modeling of coupled drug and drug-encapsulated nanoparticle transport in patient-specific coronary artery walls

Hossain

Hossainy²,

Bazilevs

et al. 2011

Comput Mech

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“…To test whether this vascular paint could be used to treat diseased areas of the vasculature, we tested whether the adhesive gel could be coated onto atherosclerotic plaques. A mouse model of atherosclerosis was used [hypercholesterolemic apolipoprotein E-deficient (apoE −/− ) mice] (32), rather than a pig or rabbit model, to take advantage of in vivo molecular imaging tools developed for mice (4,7,32,33). There is no widely accepted animal model for human vulnerable plaques, but histological analysis of plaque morphology can provide valuable insights into the inflammatory activity of a plaque (2,33).…”

Section: Painted Atherosclerotic Plaques Have Reduced Inflammation Anmentioning

confidence: 99%

“…One prominent example involves the rupture of the endothelium or endothelialized fibrous cap on atherosclerotic plaques, a trigger of heart attacks and strokes (2). Although many technologies are being developed to identify plaques at risk of rupturing (3)(4)(5)(6), effective local treatments for these vulnerable plaques do not currently exist (7,8). Substantial effort has been devoted to creating devices that locally deliver therapeutics to diseased vasculature (7,(9)(10)(11).…”

mentioning

confidence: 99%

“…Although many technologies are being developed to identify plaques at risk of rupturing (3)(4)(5)(6), effective local treatments for these vulnerable plaques do not currently exist (7,8). Substantial effort has been devoted to creating devices that locally deliver therapeutics to diseased vasculature (7,(9)(10)(11). The ideal device would shield the diseased vasculature from the bulk blood stream and stabilize the diseased tissue without causing substantial damage to it, but this has not yet been achieved (12,13).…”

mentioning

confidence: 99%

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Painting blood vessels and atherosclerotic plaques with an adhesive drug depot

Kastrup

Nahrendorf

Figueiredo

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

118

102

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The treatment of diseased vasculature remains challenging, in part because of the difficulty in implanting drug-eluting devices without subjecting vessels to damaging mechanical forces. Implanting materials using adhesive forces could overcome this challenge, but materials have previously not been shown to durably adhere to intact endothelium under blood flow. Marine mussels secrete strong underwater adhesives that have been mimicked in synthetic systems. Here we develop a drug-eluting bioadhesive gel that can be locally and durably glued onto the inside surface of blood vessels. In a mouse model of atherosclerosis, inflamed plaques treated with steroid-eluting adhesive gels had reduced macrophage content and developed protective fibrous caps covering the plaque core. Treatment also lowered plasma cytokine levels and biomarkers of inflammation in the plaque. The drugeluting devices developed here provide a general strategy for implanting therapeutics in the vasculature using adhesive forces and could potentially be used to stabilize rupture-prone plaques.biomaterials | catechol | delivery | endoluminal paving

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“…Investigators have also tried coating blood vessels with various types of biogels, but this approach has not been suitable for atherosclerosis, because the gels are too short-lived in the setting of arterial blood flow. 14, 15 …”

mentioning

confidence: 99%

Making Things Stick in the Fight Against Atherosclerosis

Tabas

2013

Circulation Research

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Prevention of atherosclerotic vascular disease through systemic risk factor management has had great success, but cardiovascular disease is still the leading cause of death. One approach to this treatment gap is complementary arterial wall-based therapy that inhibits either the trigger of atherosclerosis, lipoprotein retention, or its pathobiological consequences, non-resolving inflammation. A recent paper by Kastrup et al describes a technical advance that brings this approach closer to reality. The investigators have developed and validated a drug-eluting adhesive biogel that has the durability and stability to provide chronic therapy directly to plaques in the setting of pulsatile arterial blood flow. This advance expands the opportunity to develop drugs that retard atherosclerotic plaque progression and promote plaque resolution and regression.

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Plaque stabilisation by systemic and local drug administration

Cited by 7 publications

References 34 publications

Mathematical modeling of coupled drug and drug-encapsulated nanoparticle transport in patient-specific coronary artery walls

Mathematical modeling of coupled drug and drug-encapsulated nanoparticle transport in patient-specific coronary artery walls

Painting blood vessels and atherosclerotic plaques with an adhesive drug depot

Making Things Stick in the Fight Against Atherosclerosis

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