Plaque volume derived from three-dimensional reconstruction of coronary angiography predicts the fractional flow reserve

Kolozsvári, Rudolf; Tar, Balázs; Lugosi, P; Santa, J; Beres, Z.; Ungvári, Tamás; Polgár, Péter; Kőszegi, Zsolt

doi:10.1016/j.ijcard.2011.04.010

Cited by 11 publications

(8 citation statements)

References 22 publications

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“…Theoretically, pressure drop across the stenosis is related with viscous friction, flow separation and turbulence. The loss of viscous friction is determined by stenosis length and MLA, and these parameters can be measured by IVUS . In this study, the independent IVUS predictors of myocardial ischemia (FFR < 0.80) were MLA significance according to lesion location and IVUS measured lesion length.…”

Section: Discussionmentioning

confidence: 67%

“…Some investigators have evaluated the relationship between plaque volume and FFR using different methods. Kolozsvári et al have reported that plaque volume measured by three‐dimensional (3D) reconstruction of coronary angiography is an important parameter of functional significance and Kristensen documented a significant correlation between FFR and plaque volume using coronary multidetector computed tomography (MDCT) , however, the plaque volume measured by 3D‐QCA or MDCT is different from that directly measured by IVUS. Although the Phantom trial analyzed the relationship between FFR and plaque volume and found no correlation between the two parameters , it included only small vessels and relatively short lesions.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Relationship between intravascular ultrasound parameters and fractional flow reserve in intermediate coronary artery stenosis of left anterior descending artery: Intravascular ultrasound volumetric analysis

Yang

Tahk

Lim

et al. 2013

Cathet Cardio Intervent

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Section: Discussionmentioning

confidence: 67%

Section: Discussionmentioning

confidence: 99%

Relationship between intravascular ultrasound parameters and fractional flow reserve in intermediate coronary artery stenosis of left anterior descending artery: Intravascular ultrasound volumetric analysis

Yang

Tahk

Lim

et al. 2013

Cathet Cardio Intervent

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“…However, a recent report suggested that the plaque burden of a stented segment affects the FFR value rather than the luminal area 23 ) . In addition, another study has shown that not only luminal narrowing but also plaque burden may affect the FFR derived from CT scanning 24 ) . Unfortunately, we have no evidence that there was a difference in atherosclerotic burden between the lower LDL cholesterol group and the higher LDL cholesterol group in the present study.…”

Section: Discussionmentioning

confidence: 99%

Lower Level of Low Density Lipoprotein Cholesterol is Associated with a Higher Increase in the Fractional Flow Reserve in Patients with Fixed-dose Rosuvastatin

Hashikata

Tojo

Muramatsu

et al. 2018

JAT

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Aim: Fractional flow reserve (FFR) reflects on the diffuse atherosclerosis per coronary artery. It is unknown whether the statin therapy affects long term FFR after stenting. The aim of this study was to evaluate the long term FFR after stent implantation in patients who are intaking fixed-dose rosuvastatin.Methods: A total of 22 patients with stable angina pectoris were enrolled. The values of FFR were measured before, immediately after, and 18 months after (follow-up day) the implantation of everolimus eluting stent (EES; Promus Element™ or Promus Element Plus™). A fixed dose of rosuvastatin at 5 mg/day was administrated to all patients.Results: Of the 22 patients, 2 were excluded because of adverse effect of rosuvastatin and in-stent total occlusion after EES implantation. Overall, the values of FFR immediately after and 18 months after EES implantation did not show significant change (from 0.90 ± 0.05 to 0.88 ± 0.06, p = 0.16). However, there was a significant negative correlation between low density lipoprotein (LDL) cholesterol level at follow-up day and changes in the value of FFR (p = 0.01, r = −0.74). There was an increase in the FFR value after stenting in 8 out of 9 patients with LDL cholesterol level below 75 mg/dl (area under the curve 0.92, p = 0.0005).Conclusions: LDL cholesterol level was associated with the change in the FFR value in patients following stent implantation. Lower LDL cholesterol tended to improve in the long-term FFR, underscoring the importance of lowering LDL cholesterol to prevent the progression of coronary atherosclerosis.

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“…However, QFR in our research was measured both post-PCI and at the 1-year follow-up, and significant in-stent restenosis is a major contributor to an increased pressure gradient across the stented segment and lower QFR value at the time of follow-up. The study by Kolozsvári et al suggested that both luminal narrowing and plaque burden may affect FFR derived from computed tomography (CT) (16). Other studies have demonstrated that endothelial function may also affect the FFR value, though the mechanism is not completely understood (17,18).…”

Section: Discussionmentioning

confidence: 99%

Effect of Low-Density Lipoprotein Cholesterol Goal Achievement on Vascular Physiology Evaluated by Quantitative Flow Ratio in Patients Who Underwent Percutaneous Coronary Intervention

Chen

Zhong

et al. 2021

Front. Cardiovasc. Med.

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Purpose: The change in coronary physiology from lipid-lowering therapy (LLT) lacks an appropriate method of examination. Quantitative flow ratio (QFR) is a novel angiography-based approach allowing rapid assessment of coronary physiology. This study sought to determine the impact of low-density lipoprotein cholesterol (LDL-C) goal achievement on coronary physiology through QFR.Methods: Cases involving percutaneous coronary intervention (PCI) and 1-year angiographic follow-up were screened and assessed by QFR analysis. Patients were divided into two groups according to the LDL-C level at the 1-year follow-up: (1) goal-achievement group (LDL-C < 1.8 mmol/L or reduction of ≥50%, n = 146, lesion = 165) and (2) non-achievement group (n = 286, lesion = 331). All QFR data and major adverse cardiovascular and cerebrovascular events (MACCEs) at 1 year were compared between groups.Results: No differences between the groups in quantitative coronary angiography (QCA) data or QFR post-PCI were found. At the 1-year follow-up, lower percentage diameter stenosis (DS%) and percentage area stenosis (AS%) were recorded in the goal-achievement group (27.89 ± 10.16 vs. 30.93 ± 12.03, p = 0.010, 36.57 ± 16.12 vs. 41.68 ± 17.39, p = 0.003, respectively). Additionally, a better change in QFR was found in the goal-achievement group (0.003 ± 0.068 vs. −0.018 ± 0.086, p = 0.007), with a lower incidence of physiological restenosis and MACCEs (2.1 vs. 8.4%, p = 0.018, 5.4 vs. 12.6%, p = 0.021, respectively).Conclusion: Evaluated by QFR, patients who achieved the LDL-C goal appear to have a better coronary physiological benefit. This group of patients also has a better clinical outcome.

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Plaque volume derived from three-dimensional reconstruction of coronary angiography predicts the fractional flow reserve

Cited by 11 publications

References 22 publications

Relationship between intravascular ultrasound parameters and fractional flow reserve in intermediate coronary artery stenosis of left anterior descending artery: Intravascular ultrasound volumetric analysis

Relationship between intravascular ultrasound parameters and fractional flow reserve in intermediate coronary artery stenosis of left anterior descending artery: Intravascular ultrasound volumetric analysis

Lower Level of Low Density Lipoprotein Cholesterol is Associated with a Higher Increase in the Fractional Flow Reserve in Patients with Fixed-dose Rosuvastatin

Effect of Low-Density Lipoprotein Cholesterol Goal Achievement on Vascular Physiology Evaluated by Quantitative Flow Ratio in Patients Who Underwent Percutaneous Coronary Intervention

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