Plasma 25-Hydroxyvitamin D and 1,25-Dihydroxyvitamin D Levels in Breast Cancer Risk in Mali: A Case–Control Study

Bissan, Aboubacar D. T.; Ly, Madani; Amegonou, Awo Emmanuela H.; Sidibe, Fatoumata M.; Koné, Bocary S.; Barry, Nènè Oumou K.; Tall, Madiné; Timbiné, Lassana G.; Kouriba, Bourèma; Reynier, Pascal; Ouzzif, Zahra

doi:10.3390/diagnostics13243664

Cited by 2 publications

(1 citation statement)

References 38 publications

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“…Poor nutrition: Poor nutrition, characterized by diets high in fats and sugars, increases breast cancer risk. Studies like ( 103 ) highlight the positive impact of tailored lifestyle interventions, while ( 16 ) suggest higher plasma vitamin D levels may offer protection ( 21 ). and ( 49 ) emphasize the association between Western diets and increased risk, contrasting with the protective effect of plant-based diets.…”

Section: Resultsmentioning

confidence: 99%

A contemporary review of breast cancer risk factors and the role of artificial intelligence

Nicolis,

De Los Angeles,

Taramasco

2024

Front. Oncol.

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BackgroundBreast cancer continues to be a significant global health issue, necessitating advancements in prevention and early detection strategies. This review aims to assess and synthesize research conducted from 2020 to the present, focusing on breast cancer risk factors, including genetic, lifestyle, and environmental aspects, as well as the innovative role of artificial intelligence (AI) in prediction and diagnostics.MethodsA comprehensive literature search, covering studies from 2020 to the present, was conducted to evaluate the diversity of breast cancer risk factors and the latest advances in Artificial Intelligence (AI) in this field. The review prioritized high-quality peer-reviewed research articles and meta-analyses.ResultsOur analysis reveals a complex interplay of genetic, lifestyle, and environmental risk factors for breast cancer, with significant variability across different populations. Furthermore, AI has emerged as a promising tool in enhancing the accuracy of breast cancer risk prediction and the personalization of prevention strategies.ConclusionThe review highlights the necessity for personalized breast cancer prevention and detection approaches that account for individual risk factor profiles. It underscores the potential of AI to revolutionize these strategies, offering clear recommendations for future research directions and clinical practice improvements.

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Section: Resultsmentioning

confidence: 99%

A contemporary review of breast cancer risk factors and the role of artificial intelligence

Nicolis,

De Los Angeles,

Taramasco

2024

Front. Oncol.

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The relationship between calcidiol and calcitriol and their role in evaluating the prophylactic intake of vitamin D preparations

Krivosheev,

Kozlovsky,

Nikitina

et al. 2024

Sanitary Doctor

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The vast majority of measurements of vitamin D levels in the blood serum of patients at present, both in domestic and foreign practice, are reduced to the determination of the total concentration of calcidiol [25(OH)D] in the patient’s blood serum [25(OH)D2 + 25(OH)D3]. This is because the half-life of 25(OH)D occurs over a long period of time (two to three weeks). 25(OH)D analyses are well-established and quite economical. The biologically active metabolite of vitamin D calcitriol [1.25 (OH) 2D], is measured much less frequently because the half-life of 1.25 (OH) 2D occurs within ~four hours, and the cost of the test is quite high. These observations have led some authors to question the validity of the assessment of vitamin D levels 25(OH)D serum measurement. Our analysis of domestic and foreign literature, as well as the results of statistical studies, allow us to say that in the data set we studied, containing blood serum analyses of 67,254 inhabitants of European countries, the level of calcitriol is directly related to the level of calcidiol, and this relationship is very stable (p<0.00001). Moreover, in the case of cholecalciferol, ergocalciferol or calcidiol, the increase in the level of 25(OH)D is accompanied by an increase in 1.25 (OH) 2D, but the increase in 1.25 (OH) 2D is significantly slower than the increase in 25(OH)D, and the degree of association between these indicators is not as high (p=0.04). Thus, in most cases, the serum 25(OH)D concentration can be considered an adequate marker of vitamin D levels, however, in a number of cases, especially in the analysis of patients with a confirmed diagnosis of COVID-19, the level of the active vitamin D metabolite calcitriol 1,25(OH)2Dshould be determined much more often, along with the level of calcidiol 25(OH)D, the level of the active metabolite of vitamin D — calcitriol 1.25 (OH) 2D. Vitamin D deficiency among the population of the Russian Federation is extremely common, which is a generally recognized risk factor for insufficient activity of the immune system, a risk factor for the severity of the course and clinical consequences of a large number of diseases, so testing of vitamin D levels in blood serum should be mandatory as part of regular health checkups, especially in risk groups and especially in winter and spring.

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Plasma 25-Hydroxyvitamin D and 1,25-Dihydroxyvitamin D Levels in Breast Cancer Risk in Mali: A Case–Control Study

Cited by 2 publications

References 38 publications

A contemporary review of breast cancer risk factors and the role of artificial intelligence

A contemporary review of breast cancer risk factors and the role of artificial intelligence

The relationship between calcidiol and calcitriol and their role in evaluating the prophylactic intake of vitamin D preparations

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