Plasma 25-Hydroxyvitamin D, Vitamin D Binding Protein, and Risk of Colorectal Cancer in the Nurses' Health Study

Song, Mingyang; Konijeti, Gauree G.; Yuan, Chen; Ananthakrishnan, Ashwin N.; Ogino, Shuji; Fuchs, Charles S.; Giovannucci, Edward; Ng, Kimmie; Chan, Andrew T.

doi:10.1158/1940-6207.capr-16-0053

Cited by 41 publications

(37 citation statements)

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“…Several recent studies have investigated associations between colorectal cancer risk and vitamin D binding protein, free, and bioavailable 25-hydroxyvitamin D. Our results confirm the null association between colorectal cancer risk and vitamin D binding protein reported in four recent publications (8–11), and find an inverse association with free 25-hydroxyvitamin D more than three years after blood draw, which is consistent with results from one of the previous studies (9). One previous study (8), but not the others (9–11), reports inverse associations between total, free, and bioavailable 25-hydroxyvitamin D with colorectal cancer risk that were most apparent in participants with values of vitamin D binding protein below the median.…”

Section: Discussionsupporting

confidence: 92%

“…One previous study (8), but not the others (9–11), reports inverse associations between total, free, and bioavailable 25-hydroxyvitamin D with colorectal cancer risk that were most apparent in participants with values of vitamin D binding protein below the median. We do not find evidence of interaction between vitamin D binding protein and total or free 24-hydroxyvitamin D. Anic et al (10) report positive rather than inverse associations between total and free 25-hydroxyvitamin D with colorectal cancer risk using data from the Alpha-Tocopherol, Beta-Carotene Prevention (ATBC) trial.…”

Section: Discussionmentioning

confidence: 84%

“…However, recent studies have found mixed results for the associations between these biomarkers and colorectal cancer risk. One study reports strong inverse associations between colorectal cancer risk and free and bioavailable 25-hydroxyvitamin D (8), whereas other studies find null or modest positive associations between the biomarkers and colorectal cancer risk (9–11). Additionally, no study of bioavailable or free 25-hydroxyvitamin D has been conducted in a sample with large numbers of African Americans, whose total 25-hydroxyvitamin D levels tend to be substantially lower than in people of European descent.…”

Section: Introductionmentioning

confidence: 99%

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Total and Free Circulating Vitamin D and Vitamin D–Binding Protein in Relation to Colorectal Cancer Risk in a Prospective Study of African Americans

Andersen

Shu

Cai

et al. 2017

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background Previous studies rarely evaluated the associations between vitamin D binding protein and free vitamin D with colorectal cancer (CRC) risk. We assessed these biomarkers and total 25-hydroxyvitamin D in relation to CRC risk in a sample of African Americans. Methods Cases comprised 224 African American participants of the Southern Community Cohort Study diagnosed with incident CRC. Controls (N=440) were selected through incidence density sampling and matched to cases on age, sex, and race. Conditional logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for associations between biomarker levels and CRC risk. Results Vitamin D was inversely associated with CRC risk where the OR per-standard deviation increase in total and free 25-hydroxyvitamin D were 0.82 (95%CI: 0.66–1.02) and 0.82 (95%CI: 0.66–1.01), respectively. Associations were most apparent among cases diagnosed >3 years after blood draw: ORs for the highest tertile versus the lowest were 0.69 (95%CI: 0.21–0.93) for total 25-hydroxyvitamin D and 0.71 (95%CI: 0.53–0.97) for free 25-hydroxyvitamin D. Inverse associations were seen in strata defined by sex, BMI, and anatomic site, although not all findings were statistically significant. Vitamin D binding protein was not associated with CRC risk. Conclusion Our findings suggest that total and free 25-hydroxyvitamin D may be inversely associated with CRC risk among African Americans. Impact These findings highlight a potential role for vitamin D in CRC prevention in African Americans.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 84%

Section: Introductionmentioning

confidence: 99%

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Total and Free Circulating Vitamin D and Vitamin D–Binding Protein in Relation to Colorectal Cancer Risk in a Prospective Study of African Americans

Andersen

Shu

Cai

et al. 2017

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…Recently, several studies have reported that serum VDBP was associated with prostate, pancreatic, and bladder cancers as well as acute leukemia . Several papers have pointed that VDBP was not associated with CRC . However, it has been reported that VDBP played a role in the modulation of serum 25(OH)D levels although it was not directly corrected with the risk of CRC .…”

Section: Introductionmentioning

confidence: 99%

The association of serum vitamin D–binding protein and 25‐hydroxyvitamin D in pre‐operative and post‐operative colorectal cancer

Liang

Jiang

Chi

et al. 2019

Clinical Laboratory Analysis

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This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. Abstract Background: The association between vitamin D-binding protein (VDBP) and 25-hydroxyvitamin D (25 (OH)D) with colorectal cancer (CRC) is still ambiguous. This study was to further investigate the relationship between serum VDBP, 25 (OH)D levels and the clinical and pathological features of patients with CRC.Methods: Enzyme-linked immunosorbent assay (ELISA) and chemiluminescence immunoassay were used to analyze the VDBP and 25(OH)D concentrations in serum.Pearson's correlation analysis was applied to evaluate the association between serum VDBP and 25(OH)D levels in CRC. Conditional logistic regression was performed to analyze the prediction value of serum VDBP or 25(OH)D as a risk factor for CRC. Results:The serological levels of 25(OH)D in patients were significantly lower than in healthy individuals, while VDBP levels were significantly higher than in healthy controls. The serum VDBP in pre-operative was significantly lower than in post-operative samples, while the serum 25(OH)D from pre-operative patients was significantly higher than post-operative patients. Patients with tumors with higher stage and increased lymph node involvement had lower serum post-operative VDBP levels. In addition, our results showed that the pre-operative VDBP level is a risk factor of CRC. Conclusions:The levels of serum 25(OH)D and VDBP were both associated with CRC.Thus, serum 25(OH)D and VDBP levels might be of value in evaluating the pathogenesis and risk of CRC in the future. Moreover, serum VDBP or 25(OH)D levels were associated with patient's clinical and pathological features providing data for risk and prognostic prediction.Colorectal cancer (CRC) is a common type of cancer worldwide. 1 In China, the estimated new cases and deaths of CRC were 376 300 and 191 000, respectively, in 2015. 2 Benefited by the development of screening tools for early detection, more and more patients could be treated at an early stage; however, the incidence and mortality of CRC among adults aged under 50 years is increasing in the United States. 3Accumulating evidence indicates that high levels of circulating vitamin D is an anti-cancer factor, which may reduce the risk of CRC. [4][5][6] Vitamin D (VD) is photochemically synthesized in the skin when exposed to ultraviolet B (UVB) radiation or ingested from food and/ or supplements. Once getting into blood circulation, VD is hydroxylated and forms 25-hydroxyvitamin D [25(OH)D] in the liver, the well-known biomarker of VD status. Then, 25(OH)D is hydroxylated and forms 1,25-dihydroxyvitamin D [1,25(OH)2D] in the kidney and other organs, the bioactive form of VD. 7 Recent studies found that free 25(OH)D may be an independent CRC prognostic biomarker. 8 Vitamin D-binding protein (VDBP), primarily vitamin D carrier ...

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“…Health Study, total circulating Vitamin D was associated with a lower risk of colorectal cancer in white women. 22 A recent international study of 17 cohorts in Western population found that Vitamin D deficiency was associated with increased colorectal cancer risk, and Vitamin D above sufficiency levels was associated with 19% to 27% lower risk. 23 Compared with Western countries, there was an inconsistent conclusion about the relationship between blood circulating Vitamin D level and colorectal cancer risk in studies of Asian countries, [24][25][26][27][28][29][30] given that lifestyle, ethnic and environmental factors are different between Asian and Western countries.…”

Section: Introductionmentioning

confidence: 99%

Association Between Blood Circulating Vitamin D and Colorectal Cancer Risk in Asian Countries: A Systematic Review and Dose-Response Meta-analysis

Zhang

Zou

Zhao

et al. 2019

Preprint

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ObjectivesTo assess the association between blood circulating Vitamin D levels and colorectal cancer risk in the Asian population. DesignThis is a systematic review and dose-response meta-analysis of observational studies that investigated the relationship between blood circulating Vitamin D levels and colorectal cancer risk in the Asian population. Data SourcesRelevant studies were identified through a literature search in MEDLINE, EMBASE, studies published in peer-reviewed journals investigating the association between blood circulating Vitamin D levels and the risk of colorectal cancer and/or adenoma in Asian countries. Data extraction and synthesis:Two authors independently extracted data and assessed the quality of included studies. Studyspecific ORs were pooled using a random-effects model. A dose-response meta-analysis was performed with generalized least squares regression. We applied the Newcastle-Ottawa Scale quality assessment to evaluate the quality of the selected studies. ResultsThe eight included studies encompassed a total of 2,916 cases and 6,678 controls. The pooled ORs of colorectal cancer for the highest versus lowest categories of blood circulating Vitamin D levels was 0.75 [95% CI, 0.58-0.97] up to 36.5 ng/mL in the Asian population. There was heterogeneity among the studies (I 2 =53.9%, P heterogeneity =0.034). The dose-response metaanalysis indicated a significant linear relationship (P non-linearity =0.11). An increment of 16 ng/mL in blood circulating Vitamin D level corresponded to an OR of 0.79 [95% CI, 0.64-0.97]. ConclusionsThe results of this meta analysis indicate that blood circulating Vitamin D level is associated with decreased risk of colorectal cancer in Asian countries. The dose-response meta-analysis shows that the strength of this association among the Asian population is similar to that among the Western population. Our study suggests that the Asian population should improve nutritional status and maintain a higher level of blood circulating Vitamin D.

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Plasma 25-Hydroxyvitamin D, Vitamin D Binding Protein, and Risk of Colorectal Cancer in the Nurses' Health Study

Cited by 41 publications

References 50 publications

Total and Free Circulating Vitamin D and Vitamin D–Binding Protein in Relation to Colorectal Cancer Risk in a Prospective Study of African Americans

Total and Free Circulating Vitamin D and Vitamin D–Binding Protein in Relation to Colorectal Cancer Risk in a Prospective Study of African Americans

The association of serum vitamin D–binding protein and 25‐hydroxyvitamin D in pre‐operative and post‐operative colorectal cancer

Association Between Blood Circulating Vitamin D and Colorectal Cancer Risk in Asian Countries: A Systematic Review and Dose-Response Meta-analysis

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