Plasma-activated interfaces for biomedical engineering

Liu, Pei; Wang, Guomin; Ruan, Qingdong; Tang, Kaiwei; Chu, Paul K.

doi:10.1016/j.bioactmat.2021.01.001

Cited by 21 publications

(18 citation statements)

References 143 publications

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“…Plasma processing is a promising and fast‐developing manufacturing tool in industrial and biomedical engineering applications. [ 26,27 ] Plasma (ionized gas) consists of excited species, electrons, ions, radicals, neutral molecules, as well as short‐wave radiation. This provides an effective, low temperature, and environmentally friendly method for surface modification.…”

Section: Resultsmentioning

confidence: 99%

Plasma‐Assisted Deposition of Silk Fibroin on Different Surfaces

Arkhangelskiy

Maniglio

Bucciarelli

et al. 2021

Adv Materials Inter

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The development of simple and versatile methods for the deposition of biocompatible coatings to protect or functionalize a range of materials with different shapes is an important challenge. In this study, a versatile, room‐temperature process is presented for the deposition of silk fibroin on different materials viz., glass, polyethylene terephthalate, Ti alloy, and poly(dimethylsiloxane). Coating with thin fibroin films is achieved using an atmospheric plasma torch, wherein a silk‐fibroin aerosol solution is used as the working gas. The method consists of two sequential processes: plasma modification of the surface, followed by plasma‐assisted deposition. This allows enhanced adhesion of the protein to the underlying surfaces, and the deposition even on non‐planar and flexible substrates. The deposited films are characterized by optical microscopy, atomic force microscopy, and scanning electron microscopy. Primary and secondary structures of the surface‐attached fibroin films are investigated by Fourier transform infrared spectroscopy. The proposed approach offers a tunable and controllable strategy for the controlled deposition of proteins on complex surfaces, for a wide range of biomedical and technological applications, including dentistry and bioelectronics.

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Section: Resultsmentioning

confidence: 99%

Plasma‐Assisted Deposition of Silk Fibroin on Different Surfaces

Arkhangelskiy

Maniglio

Bucciarelli

et al. 2021

Adv Materials Inter

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“…Recently, CAP has attracted much attention in the biotechnology and medical fields [1,2]. Various studies have been conducted on the effect of non-thermal plasmas for wound healing, blood coagulation, skin regeneration, and action against cancer cells [3]. Therefore, it is of great interest and importance to elucidate how the structures, motions, and associations of biomacromolecules are affected by plasma irradiation from the perspective of plasma biology and biomolecular science.…”

Section: Introductionmentioning

confidence: 99%

Cold Atmospheric Plasma Modification of Amyloid β

Yagi-Utsumi

Tanaka

Otsubo

et al. 2021

IJMS

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Cold atmospheric plasma (CAP) has attracted much attention in the fields of biotechnology and medicine owing to its potential utility in clinical applications. Recently accumulating evidence has demonstrated that CAP influences protein structures. However, there remain open questions regarding the molecular mechanisms behind the CAP-induced structural perturbations of biomacromolecules. Here, we investigated the potential effects of CAP irradiation of amyloid β (Aβ), an amyloidogenic protein associated with Alzheimer’s disease. Using nuclear magnetic resonance spectroscopy, we observed gradual spectral changes in Aβ after a 10 s CAP pretreatment, which also suppressed its fibril formation, as revealed by thioflavin T assay. As per mass spectrometric analyses, these effects were attributed to selective oxidation of the methionine residue (Met) at position 35. Interestingly, this modification occurred when Aβ was dissolved into a pre-irradiated buffer, indicating that some reactive species oxidize the Met residue. Our results strongly suggest that the H2O2 generated in the solution by CAP irradiation is responsible for Met oxidation, which inhibits Aβ amyloid formation. The findings of the present study provide fundamental insights into plasma biology, giving clues for developing novel applications of CAP.

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“…Electrical excitation is usually adopted due to the more portable and simpler process. Plasmas are classified as nonthermal or thermal ones based on the temperature as well as metal and nonmetal ones according to the plasma composition 70 . Since the energetic metastable species in the plasma have high energy, artificial plasmas are created to perform materials modification and plasma techniques are used widely in the fields of semiconductors, coatings, and microelectronics 71 …”

Section: Plasma Technologymentioning

confidence: 99%

“…Atmospheric pressure nonthermal plasmas are more convenient without needing a complicated vacuum chamber and the floating electrode DBD can modify the surface properties of materials such as hydrophilicity and oxidation tendency without damaging the structure. However, the energy and interactions of the plasma are insufficient to alter the materials substantially, meaning that surfaces are modified by mild plasma effects such as doping and weak sputtering 70 . The nonthermal plasma discharge can also be maintained at several Torrs of low pressure and small DC, RF, or ECR and is effective for etching and deposition of material surfaces.…”

Section: Plasma Technologymentioning

confidence: 99%

“…Plasmas are classified as nonthermal or thermal ones based on the temperature as well as metal and nonmetal ones according to the plasma composition. 70 Since the energetic metastable species in the plasma have high energy, artificial plasmas are created to perform materials modification and plasma techniques are used widely in the fields of semiconductors, coatings, and microelectronics. 71 Both nonthermal and thermal plasmas are triggered by excited electrons from external sources such as the direct current (DC) discharges, radio frequency (RF) discharges, pulsed DC discharges, alternative current (AC) glow discharges, low-frequency discharges, electron cyclotron resonances (ECR), dielectric barrier discharges (DBD), and microwave frequency discharges.…”

Section: Fundamental Plasma Physicsmentioning

confidence: 99%

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Plasma modified and tailored defective electrocatalysts for water electrolysis and hydrogen fuel cells

Luo

Huang

et al. 2022

EcoMat

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Carbon dioxide generated by the combustion of fossil fuels exacerbates global environmental problems and hydrogen produced by renewable energy is a viable alternative in the continuous transition to sustainable and eco‐conscience development. Electrocatalysts are vital to electrocatalytic reactions and plasma surface modification is one of the promising techniques to modify nanoscale electrocatalysts for water splitting. Up to now, a comprehensive review on the latest developments, challenges, and opportunities of plasma‐tailored defective electrocatalysts for water electrolysis and hydrogen fuel cells is lacking. This paper systematically summarizes the current status of hydrogen production and fuel cell technologies, plasma principles and advantages, plasma‐tailored defective electrocatalysts from the perspective of water splitting and fuel cell applications, advanced characterization of defects, relationship between materials structure and catalytic activity of electrocatalysts, and finally challenges, opportunities, and future roadmap of plasma technologies. This review serves as a reference for future development of hydrogen technologies and offers insights into the structural tailoring of catalytic materials.

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Plasma-activated interfaces for biomedical engineering

Cited by 21 publications

References 143 publications

Plasma‐Assisted Deposition of Silk Fibroin on Different Surfaces

Plasma‐Assisted Deposition of Silk Fibroin on Different Surfaces

Cold Atmospheric Plasma Modification of Amyloid β

Plasma modified and tailored defective electrocatalysts for water electrolysis and hydrogen fuel cells

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