Plasma adiponectin levels in schizophrenia and role of second-generation antipsychotics: A meta-analysis

Second-generation antipsychotics and adiponectin levels in schizophrenia: A comparative meta-analysis

“…Our findings seem in line with our previous complementary work showing lower adiponectin levels, as compared with healthy controls, among people taking Clozapine and Olanzapine, but not Risperidone (Bartoli et al, 2015a). Although the present study was not suitable to correlate adiponectin levels with weight gain and other metabolic variations, we could hypothesize a key role of adiponectin on metabolic adverse effects of Clozapine and Olanzapine since these pharmacological agents are known to be highly associated with metabolic abnormalities.…”

“…In a previous meta-analysis, we explored differences in adiponectin between people with schizophrenia and healthy controls, showing a non-significant trend for lower levels among individuals with schizophrenia. However, we also preliminarily identified the potential role of several SGAs, especially Clozapine and Olanzapine, in decreasing adiponectin (Bartoli et al, 2015a), though individual studies did not find any significant differences (e.g., Togo et al, 2004;Tsai et al, 2011). Nevertheless, there is a need to synthesize data on the effects of different SGAs on adiponectin levels.…”

“…Nonetheless, it is likely that the relationship between SGAs and metabolic abnormalities might be much more complex (Bartoli et al, 2015a). For example, there is extensive evidence that elevated leptin levels are associated with SGA treatment, particularly clozapine and olanzapine (Roerig et al, 2011).…”

Schizoaffective disorder and metabolic syndrome: A meta-analytic comparison with schizophrenia and other non-affective psychoses

“…First there was a lack of information on potential explanatory factors for higher risk of MetS, such as differences on prescribed psychotropic medications, adiponectin levels, physical exercise, sedentary behaviors, cigarette smoking, unhealthy dietary patterns (Bartoli et al, 2015;Clerici et al, 2014). Therefore, we could not assess which factors may mediate the association between SD and MetS, and the underlying mechanisms remain unknown.…”

The Relationship between Body Weight Change and Body Constitutions of Traditional Chinese Medicine in Patients with Schizophrenia

“…There is growing concern regarding metabolic side effects such as weight gain and insulin resistance and syndromes such as dyslipidemia and type 2 diabetes mellitus [7–10]. Currently, there is virtually no way of predicting who will be affected by antipsychotic-induced weight gain and identifying individuals at a higher risk of the same.…”