Plasma adiponectin, visfatin, leptin, and resistin levels and the onset of colonic polyps in patients with prediabetes

Deng, Lili; Zhao, Xiaotong; Chen, Mingwei; Hua, Jinping; Zhang, Qunhui; Chen, Ruofei; Wang, Yalei

doi:10.1186/s12902-020-0540-7

Cited by 15 publications

(8 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this study, we firstly revealed the differences of adiponectin, nesfatin-1, IL-6, and TNF-a between prediabetes and T2DM or healthy individuals in Chinese population. Our results disclosed that adiponectin levels in prediabetes were distinctly lower than those in the healthy, while no significant difference was observed when compared to those in T2DM, which was consistent with the consequences of previous studies (30,31). Our data also proved that nesfatin-1 levels in prediabetes were obviously higher than those in T2DM but no significant difference when compared to those in the healthy, which is the first delineation, despite the fact that others demonstrated mildly lower nesfatin-1 levels in impaired fasting glycemia and impaired glucose tolerance in contrast to those in the healthy group (21).…”

Section: Discussionsupporting

confidence: 93%

The Variation and Correlation of Serum Adiponectin, Nesfatin-1, IL-6, and TNF-α Levels in Prediabetes

Huang

Liang

et al. 2022

Front. Endocrinol.

View full text Add to dashboard Cite

BackgroundThe variation and correlation among adiponectin, nesfatin-1, tumor necrosis factor α (TNF-α), and interleukin 6 (IL-6), which may be involved in the development of the decline of health into prediabetes and diabetes, have not been elucidated. This study aims to investigate the roles of these cytokines in this process.MethodsSeventy-two type 2 diabetes mellitus (T2DM) patients, 75 prediabetics, and 72 healthy individuals were enrolled in our case control study. Serum adiponectin, nesfatin-1, TNF-α, and IL-6 were tested with appropriate kits, and primary data were analyzed with correct methods.ResultsSerum levels of each cytokine in patients with prediabetes were between T2DM and the healthy, and significant differences were found among them. TNF-α and nesfatin-1 levels in T2DM were obviously different compared to prediabetes or the healthy; IL-6 and adiponectin levels in the healthy group were significantly changed in contrast to prediabetes or T2DM. Correlation analysis found that in prediabetics, adiponectin was positively correlated with TNF-α (R = 0.2939, P = 0.0105) and IL-6 (R = 0.3918, P = 0.0005), and their relationship was greatly strengthened in prediabetes accompanied by insulin resistance (TNF-α: R = 0.7732, P < 0.0001, IL-6: R = 0.6663, P = 0.0005). We also demonstrated that declined adiponectin (OR = 6.238, P = 0.019) and nesfatin-1 (OR = 2.812, P = 0.01) and elevated TNF-α (OR = 5.541, P = 0.001) were risk factors for prediabetes toward diabetes.ConclusionsThis research proved significant variations of adiponectin, nesfatin-1, IL-6, and TNF-α levels in the healthy, prediabetics, and T2DM, suggesting a slow and gradual change during the progression from a healthy condition toward diabetes via prediabetes.

show abstract

Section: Discussionsupporting

confidence: 93%

The Variation and Correlation of Serum Adiponectin, Nesfatin-1, IL-6, and TNF-α Levels in Prediabetes

Huang

Liang

et al. 2022

Front. Endocrinol.

View full text Add to dashboard Cite

show abstract

“…In this study, we rstly revealed the differences of adiponectin, nesfatin-1, IL-6 and TNF-α between prediabetes and T2DM or healthy individuals in Chinese population. Our results demonstrated that adiponectin levels in prediabetes were distinctly lower than that in the healthy, while no signi cant difference was observed when compared to T2DM, which was consistent with the consequences of previous studies [30,31] . Another research reported signi cant reduction of adiponectin in impaired fasting glucose group compared with hyperglycemic group [31] .…”

Section: Discussionsupporting

confidence: 93%

The Variation and Correlation of Serum Adiponectin, Nesfatin-1, IL-6 and TNF-α Levels in Prediabetes

Huang

Liang

et al. 2021

Preprint

View full text Add to dashboard Cite

Background: The variation and correlation among adiponectin, nesfatin-1, TNF-α and IL-6, which involve in the process from healthy to prediabetes and diabetes have not been elucidated. This study aims to investigate the roles of them in this process. Methods: 72 T2DM, 75 prediabetes and 72 healthy individuals were enrolled and serum adiponectin, nesfatin-1, TNF-α and IL-6 were tested with appropriate kit, and primary data were analyzed with correct method. Results: serum levels of each factor in prediabetes were between T2DM and healthy, and significant differences were found among them. TNF-α and nesfatin-1 levels in T2DM obviously different compared to prediabetes or healthy; IL-6 and adiponectin levels in the healthy group were significantly changed in contrast to prediabetes or T2DM. Correlation analysis found that in prediabetes, adiponectin was positively correlated with TNF-α (R=0.2939, P=0.0105) and IL-6 (R=0.3918, P=0.0005), and the relationship greatly strengthened when prediabetes accompanied by insulin resistant (TNF-α: R=0.7732, P<0.0001, IL-6: R=0.6663, P=0.0005). We also demonstrated that declined adiponectin (OR=6.238, P=0.019), nesfatin-1 (OR=2.812, P=0.01) and elevated TNF-α (OR=5.541, P=0.001) were risk factors for prediabetes towards diabetes. Conclusions: this research proved significant variations of adiponectin, nesfatin-1, IL-6 and TNF-α levels in the healthy, prediabetes and T2DM, suggesting a slow and gradual change during the progression of healthy condition toward diabetes via prediabetes.

show abstract

“…However, the exact and discrete pathophysiological links between obesity and T2DM are not yet fully elucidated. There is enough evidence to suggest that changes in adipocytokine secretion do contribute to defective insulin production/action and, concomitantly, result in peripheral insulin resistance [ 13 , 14 , 15 , 16 , 17 ]. Adipokines such as adiponectin, leptin resistin, visfatin, ghrelin and chemerin seem to play an important role in the onset, progression and complications of T2DM [ 14 , 17 , 18 , 19 , 20 , 21 , 22 ].…”

Section: Introductionmentioning

confidence: 99%

Differential Association of Selected Adipocytokines, Adiponectin, Leptin, Resistin, Visfatin and Chemerin, with the Pathogenesis and Progression of Type 2 Diabetes Mellitus (T2DM) in the Asir Region of Saudi Arabia: A Case Control Study

Mir

Alghamdi

et al. 2022

JPM

View full text Add to dashboard Cite

Background: Sedentary lifestyles, urbanization and improvements in socio-economic status have had serious effects on the burden of diabetes across the world. Diabetes is one of the 10 leading causes of death globally, and individuals with diabetes have a 2–3-fold increased risk of all-cause mortality. Adipose tissue is increasingly understood as a highly active endocrine gland that secretes many biologically active substances, including adipocytokines. However, the exact and discrete pathophysiological links between obesity and T2DM are not yet fully elucidated. Methods: In the current study, we present the association of five diverse adipocytokines, adiponectin, leptin, resistin, visfatin and chemerin, with T2DM in 87 patients (46 males and 41 females) with type 2 diabetes mellitus and 85 healthy controls (44 males and 41 females) from the Asir region of Saudi Arabia. The patients were divided into four groups: normal BMI, overweight, obese and severely obese. The baseline biochemical characteristics, including HbA1c and anthropometric lipid indices, such as BMI and waist–hip ratio, were determined by standard procedures, whereas the selected adipokine levels were assayed by ELISA. Results: The results showed significantly decreased levels of adiponectin in the T2DM patients compared to the control group, and the decrease was more pronounced in obese and severely obese T2DM patients. Serum leptin levels were significantly higher in the females compared to the males in the controls as well as all the four groups of T2DM patients. In the male T2DM patients, a progressive increase was observed in the leptin levels as the BMI increased, although these only reached significantly altered levels in the obese and severely obese patients. The serum leptin levels were significantly higher in the severely obese female patients compared to the controls, patients with normal BMI, and overweight patients. The leptin/adiponectin ratio was significantly higher in the obese and severely obese patients compared to the controls, patients with normal BMI, and overweight patients in both genders. The serum resistin levels did not show any significant differences between the males and females in thr controls or in the T2DM groups, irrespective of the BMI status of the T2DM patients. The visfatin levels did not reveal any significant gender-based differences, but significantly higher levels of visfatin were observed in the T2DM patients, irrespective of their level of obesity, although the higher values were observed in the obese and highly obese patients. Similarly, the serum chemerin levels in the controls, as well as in T2DM patients, did not show any significant gender-based differences. However, in the T2DM patients, the chemerin levels showed a progressive increase, with the increase in BMI reaching highly significant levels in the obese and severely obese patients, respectively. Conclusion: In summary, it is concluded that significantly altered concentrations of four adipokines, adiponectin, leptin, visfatin and chemerin, were found in the T2DM patient group compared to the controls, with more pronounced alterations observed in the obese and highly obese patients. Thus, it can be surmised that these four adipokines play a profound role in the onset, progression and associated complications of T2DM. In view of the relatively small sample size in our study, future prospective studies are needed on a large sample size to explore the in-depth relationship between adipokines and T2DM.

show abstract

Plasma adiponectin, visfatin, leptin, and resistin levels and the onset of colonic polyps in patients with prediabetes

Cited by 15 publications

References 29 publications

The Variation and Correlation of Serum Adiponectin, Nesfatin-1, IL-6, and TNF-α Levels in Prediabetes

The Variation and Correlation of Serum Adiponectin, Nesfatin-1, IL-6, and TNF-α Levels in Prediabetes

The Variation and Correlation of Serum Adiponectin, Nesfatin-1, IL-6 and TNF-α Levels in Prediabetes

Differential Association of Selected Adipocytokines, Adiponectin, Leptin, Resistin, Visfatin and Chemerin, with the Pathogenesis and Progression of Type 2 Diabetes Mellitus (T2DM) in the Asir Region of Saudi Arabia: A Case Control Study

Contact Info

Product

Resources

About