Plasma Adrenocorticotrophic Hormone in Addison's Disease and its Modification by the Administration of Adrenal Steroids

Bethune, John E.; Nelson, Don H.; Thorn, George W.

doi:10.1172/jci103571

Cited by 37 publications

(13 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The calculated plasma ACTH concentration produced was about 1 to 4 mU per 100 ml. Higher rates of ACTH infusion, calculated to produce a plasma ACTH concentration of the order reported in Addison's disease (47) or in the stressed dog (63), resulted in significant rise of aldosterone secretion.…”

Section: Discussionmentioning

confidence: 95%

“…The measured blood flow rate in the individual animal on the day of the experiment was the basis of calculation of ratio of intra-adrenal arterial infusion so that a physiological or appropriate pharmacological change was contrived. For example, in Addison's disease the plasma ACTH concentration is 8.4 + 7.4 mU per 100 ml (47,48 Alteration in the ionic composition of adrenal arterial blood It was of great importance to know whether a fluid to be infused would affect the Na and K concentrations of adrenal arterial blood. The concurrent decrease of Na and increase of K in adrenal arterial blood is a potent specific stimulus of aldosterone secretion which may increase 10-to 30-fold without significant change of cortisol or corticosterone secretion, although this latter is not an invariable finding.…”

Section: Adrenal Blood Flowmentioning

confidence: 99%

See 1 more Smart Citation

Humoral Stimulation of Adrenal Cortical Secretion*

Blair‐West¹,

Coghlan²,

Denton³

et al. 1962

J. Clin. Invest.

160

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 95%

Section: Adrenal Blood Flowmentioning

confidence: 99%

Humoral Stimulation of Adrenal Cortical Secretion*

Blair‐West¹,

Coghlan²,

Denton³

et al. 1962

J. Clin. Invest.

160

View full text Add to dashboard Cite

“…Likewise, high plasma ACTH concentrations in Addison's disease have been repeatedly confirmed by bioassay methods (23,39,41,42) and by radioimmunoassay as well (1,32), after the initial report of Taylor, Albert, and Sprague (43). Extraordinarily high levels were found by Nelson, Meakin, and Thorn (44) in patients subjected to bilateral adrenalectomy for Cushing's syndrome associated with bilateral adrenal hyperplasia.…”

Section: U Insulin/kgmentioning

confidence: 86%

Radioimmunoassay of ACTH in plasma

Berson¹,

Yalow²

1968

J. Clin. Invest.

472

133

View full text Add to dashboard Cite

A B S T R A C T Techniques are described in detail for a radioimmunoassay of plasma adrenocorticotropin (ACTH) that is capable of detecting hormone in unextracted normal human plasma at 1: 5 dilution under the conditions described. The sensitivity of the assay is at the level of 1 ,qLug/ml (equivalent to 0.014 mU/100 ml).In normal subjects ACTH concentrations averaged 22 ,uug/ml (equivalent to 0.308 mU/100 ml) plasma at 8-10 a.m. In a smaller group the concentrations averaged 9.6 lqqg/ml (equivalent to 0.134 mU/100 ml) at 10-11 p.m. Although a circadian rhythm in normal subjects was not always well marked throughout the daytime hours, plasma ACTH usually fell to its lowest value in the late evening. In hospital patients who were not acutely ill, concentrations were infrequently above 100 /A/Ag/ml in the morning and usually fell to significantly lower levels in the late evening. Severely ill hospital patients occasionally exhibited a.m. concentrations above 200 /Apg/ml.In a group of subjects showing frequent spiking -of plasma 17-OHCS concentrations throughout the day parallel spiking of plasma ACTH as well was generally observed.Metyrapone produced marked increases in plasma ACTH within 24 hr in all cases and generally within 3-6 hr except when started late in the day. Dexamethasone brought about a persistent reduction in plasma ACTH in a patient under continued treatment with metyrapone.Hypoglycemia, electroshock, surgery under general anesthesia, histalog and vasopressin administration were usually followed by significant in-*creases in plasma ACTH concentration. Prior

show abstract

“…Sayers and Sayers (25) showed the dependence of the adrenal ascorbic acid depletion which occurs after stress (cold, heat, histamine, and typhoid) upon an intact pituitary gland in the rat. Taylor, Albert and Sprague (26), Paris and co-workers (27), Sayers (28), and Bethune, Nelson and Thorn (29) have documented elevated plasma ACTH levels in Addisonian patients but not in normal subjects after surgery or other stress. These investigators were unable to detect ACTH in the plasma of normal subjects.…”

Section: Discussionmentioning

confidence: 99%

Acth Levels in Plasma in Preoperative and Surgically Stressed Patients*

Cooper

Nelson²

1962

J. Clin. Invest.

Self Cite

View full text Add to dashboard Cite

ACTH levels in human plasma during surgical stress have not been estimated previously. Much evidence (1-7) has accumulated, however, concerning variations in adrenal cortical steroids in plasma during and after surgery. Although an increase in plasma ACTH with stress has been noted in animal experiments, it has been suggested by some investigators that elevation of corticosteroids in plasma after surgery is controlled by changes in hepatic function and concentration of plasma corticosteroid rather than by a "direct drive" of ACTH release (8, 9).

show abstract

Plasma Adrenocorticotrophic Hormone in Addison's Disease and its Modification by the Administration of Adrenal Steroids

Cited by 37 publications

References 21 publications

Humoral Stimulation of Adrenal Cortical Secretion*

Humoral Stimulation of Adrenal Cortical Secretion*

Radioimmunoassay of ACTH in plasma

Acth Levels in Plasma in Preoperative and Surgically Stressed Patients*

Contact Info

Product

Resources

About