Plasma adrenomedullin in diabetes

Shimosawa, Tatsuo; Isaka, M.; Yamada, Satsuki; Fujita, Rie; Fujita, Toshiro; Hayashi, Michio

doi:10.1016/s0140-6736(05)64211-0

Cited by 86 publications

(52 citation statements)

References 5 publications

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“…Reverse phase high performance liquid chromatography confirmed that IR-AM in the medium of 3T3 adipocytes was eluted mainly in two positions: one corresponding to mouse AM and one to mouse AM with oxidized methionine (data not shown). Hayashi et al reported that plasma levels of AM were elevated in patients with diabetes mellitus (24). Since many cases of diabetes are associated with obesity, and adipocytes occupy a considerable portion of the body, our findings raise the possibility that AM in the blood of diabetic patients is partly derived from adipose tissue.…”

Section: Discussionsupporting

confidence: 50%

Decreased Expression of Adrenomedullin during Adipocyte-Differentiation of 3T3-L1 Cells

Totsune

Takeda

et al. 2003

Hypertens Res

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Section: Discussionsupporting

confidence: 50%

Decreased Expression of Adrenomedullin during Adipocyte-Differentiation of 3T3-L1 Cells

Totsune

Takeda

et al. 2003

Hypertens Res

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“…It has been previously reported that the plasma levels of AM are increased in patients with type 2 diabetes mellitus (19). However, Kinoshita et al (20) and the present study found no significant elevation when the effect of nephropathy was excluded.…”

Section: Discussioncontrasting

confidence: 71%

Acute hyperinsulinemia is associated with increased circulating levels of adrenomedullin in patients with type 2 diabetes mellitus

Katsuki

Sumida

Gabazza

et al. 2002

European Journal of Endocrinology

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Objective: To investigate the effect of acute hyperinsulinemia on the plasma levels of adrenomedullin (AM) in patients with type 2 diabetes mellitus. Design: We measured the plasma levels of AM in 18 patients with type 2 diabetes mellitus and in 19 normal subjects before and during a euglycemic hyperinsulinemic clamp study (the goal was for blood sugar levels of 5.24 mmol/l and insulin levels of 1200 pmol/l). Both plasma AM and serum insulin were measured by immunoradiometric assays. Results: Before the glucose clamp study there was no significant difference in the plasma levels of AM between patients with type 2 diabetes mellitus and normal subjects. During the glucose clamp study, the serum levels of insulin significantly increased (from 33:0^3:6 to 1344:6^67:8 pmol=ml; P , 0:001), as did the plasma levels of AM (from 12:8^0:7 to 14:2^0:9 fmol=ml; P , 0:03) only in patients with type 2 diabetes mellitus. There was a significant correlation between the change in circulating levels of insulin and AM ðr ¼ 0:755; P , 0:01Þ: Conclusions: Acute hyperinsulinemia induced a significant increase in the plasma levels of AM in patients with type 2 diabetes mellitus. Increased insulin may regulate circulating levels of AM in patients with type 2 diabetes mellitus.

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“…ADM is an adipokine (3) and is expressed in many different tissues, including adipose tissue, adrenal medulla, lung, heart, and kidney (1)(2)(3)(4). Its plasma level is elevated in obesity (5-7), hypertension (8,9), renal failure (8,9), type 2 diabetes (10)(11)(12), and congestive heart failure (8,13). ADM also plays an important regulatory role in both acute and chronic inflammation (14)(15)(16).…”

Section: Introductionmentioning

confidence: 99%

Plasma adrenomedullin level is related to a single nucleotide polymorphism in the adrenomedullin gene

Cheung

Ong²,

Tso³

et al. 2011

European Journal of Endocrinology

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Objective: Adrenomedullin (ADM) plays an important role in inflammation and is a marker of future cardiovascular events. We studied common single nucleotide polymorphisms (SNPs) in the gene encoding ADM and their relationship with the plasma levels of ADM and other inflammatory markers. Design and methods: Plasma ADM, interleukin 6 (IL6), fibrinogen, and C-reactive protein (CRP) were measured in 476 subjects from the population-based Hong Kong Cardiovascular Risk Factor Prevalence Study-2. Four tag SNPs in ADM were genotyped. Results: Plasma ADM level increased with decreasing plasma IL6 level (bZK0.116, PZ0.014). Plasma ADM level was not related to plasma levels of CRP and fibrinogen, and other clinical characteristics, except age (PZ0.049). The four SNPs, rs3814700, rs11042725, rs34354539, and rs4910118, had minor allele frequencies of 31.1, 28.7, 33.8, and 23.4% respectively. Carriers of the minor allele of rs4910118 had a mean plasma ADM level that was 10.5% (95% confidential interval: 2.5-17.8%) lower than the non-carriers (bZK0.115, PZ0.011). Haplotype analysis revealed a similar significant association with plasma ADM (PZ0.040). In multivariate analysis, the presence of the minor allele of rs4910118, but not plasma IL6, was independently associated with plasma ADM (PZ0.010). Conclusion: Plasma ADM correlates with plasma IL6 level, consistent with its role in inflammation. It is related to an SNP common in Chinese, independent of other covariates. ADM genotype should be included in future studies of cardiovascular risk prediction.

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Plasma adrenomedullin in diabetes

Cited by 86 publications

References 5 publications

Decreased Expression of Adrenomedullin during Adipocyte-Differentiation of 3T3-L1 Cells

Decreased Expression of Adrenomedullin during Adipocyte-Differentiation of 3T3-L1 Cells

Acute hyperinsulinemia is associated with increased circulating levels of adrenomedullin in patients with type 2 diabetes mellitus

Plasma adrenomedullin level is related to a single nucleotide polymorphism in the adrenomedullin gene

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