Plasma advanced glycation end products (AGEs) and NF-κB activity are independent determinants of diastolic and pulse pressure

Sourris, Karly C.; Lyons, Jasmine G.; Dougherty, Sonia L; Chand, Vibhasha; Straznicky, Nora E.; Schlaich, Markus P.; Grima, Mariee; Cooper, Mark E.; Kingwell, Bronwyn A.; Courten, Barbora de; Forbes, Josephine M.

doi:10.1515/cclm-2012-0850

Cited by 16 publications

(12 citation statements)

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“…This is in contrast with other studies that demonstrated an association between the plasma AGEs, CML, and CEL, and arterial stiffening in other populations. 13,14,[17][18][19] In the case of CML, it has recently been described that the trapping of CML by the RAGE in adipose tissue causes a decrease in AGE plasma levels in individuals with T2DM. 34 Therefore, plasma CML may not be a good reflection of CML accumulation in tissues in individuals with T2DM.…”

Section: Discussionmentioning

confidence: 99%

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Skin Autofluorescence and Pentosidine Are Associated With Aortic Stiffening

et al. 2016

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Abstract-Arterial stiffening, as characterized by an increase in carotid-femoral pulse-wave velocity or pulse pressure, increases the risk of cardiovascular disease, especially among individuals with type 2 diabetes mellitus. Advanced glycation end products are hypothesized to play a role in the development of arterial stiffness. Therefore, we investigated the association between skin autofluorescence, an estimate of tissue advanced glycation end products, and plasma advanced glycation end products on the one hand and arterial stiffening on the other in 862 participants of The Maastricht Study (mean age of 60 years; 45% women) with normal glucose metabolism (n=469), impaired glucose metabolism (n=140), or type 2 diabetes (n=253). Associations were analyzed with linear regression analysis and adjusted for potential confounders. We found that higher skin autofluorescence as measured by the AGE Reader and plasma pentosidine were independently associated with higher carotid-femoral pulse-wave velocity (sβ 0.10; 95% confidence interval, 0.03-0.17 and 0.10; 0.04-0.16, respectively) and central pulse pressure (sβ 0.08; 95% confidence interval 0.01-0.15 and 0.07; 0.01-0.13, respectively). The associations between skin autofluorescence and pentosidine, and carotid-femoral pulsewave velocity were more pronounced in individuals with type 2 diabetes mellitus (P-interaction<0.10). These results support the hypothesis that accumulation of advanced glycation end products is involved in arterial stiffening and may explain part of the increased risk of cardiovascular disease in individuals with type 2 diabetes mellitus. carotid to femoral pulse-wave velocity (cfPWV) or pulse pressure, both measures of aortic stiffening, in a population-based setting, including individuals with normal glucose metabolism (NGM), impaired glucose metabolism (IGM), and T2DM. In view of these considerations, the aims of our study were, first, to evaluate the independent association between SAF and plasma AGEs on the one hand and measures of arterial stiffening, ie, cfPWV, central pulse pressure, and 24-hour ambulatory pulse pressure, on the other. Second, to examine whether these associations differed between individuals with NGM, IGM, or T2DM. Methods Study Population and DesignIn this study, we used data from The Maastricht Study, an observational prospective population-based cohort study. The rationale and methodology have been described previously. 22 In brief, the study focuses on the cause, pathophysiology, complications, and comorbidities of type 2 diabetes mellitus (T2DM) and is characterized by an extensive phenotyping approach. Eligible for participation were all individuals aged between 40 and 75 years and living in the southern part of the Netherlands. Participants were recruited through mass media campaigns and from the municipal registries and the regional Diabetes Patient Registry via mailings. Recruitment was stratified according to known T2DM status for reasons of efficiency. The present report includes cross-sectional data from the ...

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Section: Discussionmentioning

confidence: 99%

“…[10][11][12][13][14][15][16][17][18][19][20] Only one case-control study investigated this association in individuals with T2DM. This study found no association between serum pentosidine and heart-brachial pulse-wave velocity or brachialankle pulse-wave velocity after adjustment for renal function.…”

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confidence: 99%

Skin Autofluorescence and Pentosidine Are Associated With Aortic Stiffening

et al. 2016

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“…Pulse pressure was calculated by subtracting the diastolic blood pressure from the systolic blood pressure. Mean arterial pressure was computed as diastolic blood pressure + pulse pressure/3 29 . Plasma lipid levels such as total cholesterol, LDL, HDL and triglycerides were measured using a standard commercial enzymatic assay (Beckman Coulter LX20PRO Analyser and Synchron) and Systems Lipid and Multi Calibrators (Beckman Coulter Diagnostics).…”

Section: Methodsmentioning

confidence: 99%

Effect of dietary advanced glycation end products on inflammation and cardiovascular risks in healthy overweight adults: a randomised crossover trial

Baye

Courten

Walker

et al. 2017

Sci Rep

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Diets high in advanced glycation end products (AGEs) are thought to be detrimental to cardiovascular health. However, there remains uncertainty about the beneficial effect of a low AGE diet on cardiovascular risk factors and inflammatory markers in overweight individuals. We thus performed a randomised, double blind, crossover trial to determine whether consumption of low AGE diets reduce inflammation and cardiovascular risks in overweight and obese otherwise healthy adults. All participants (n = 20) consumed low and high AGE diets alternately for two weeks and separated by a four week washout period. Low AGE diets did not change systolic (p = 0.2) and diastolic blood pressure (p = 0.3), mean arterial pressure (p = 0.8) and pulse pressure (p = 0.2) compared to high AGE diets. Change in total cholesterol (p = 0.3), low-density lipoprotein (p = 0.7), high-density lipoprotein (p = 0.2), and triglycerides (p = 0.4) also did not differ and there was no difference in inflammatory markers: interleukin-6 (p = 0.6), monocyte chemoattractant protein-1 (p = 0.9), tumour necrosis factor α (p = 0.2), C-reactive protein (p = 0.6) and nuclear factor kappa beta (p = 0.2). These findings indicate that consumption of low AGE diets for two weeks did not improve the inflammatory and cardiovascular profiles of overweight and obese adults.

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“…AGEs have been reported to be associated with traits including age (Jiang et al, 2012, Lopes-Virella et al, 2012), BMI, and waist to hip ratio (Amin et al, 2011), as well as gender (Jiang et al, 2012, B. K. Kilhovd, 2007) and a range of CVD risk factors including measures of blood pressure (Sourris et al, 2014), smoking (Fukushima et al, 2013), and LDL cholesterol (Lopes-Virella et al, 2012). However, the literature is conflicted.…”

Section: Discussionmentioning

confidence: 99%

Analysis of advanced glycation end products in the DHS Mind Study

Adams

Martelle

Raffield

et al. 2016

Journal of Diabetes and its Complications

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Aims Human studies of links between advanced glycation end-products (AGEs) and disease phenotypes are less common than studies of animal and cell models. Here, we examined the association of total AGEs with diabetes risk factors in a predominately type 2 diabetes (T2D) affected cohort. Methods AGEs were measured using an enzyme linked immunosorbant assay in 816 individuals from the DHS Mind Study (n=709 T2D affected), and association analyses were completed. Results Total AGEs were associated with estimated glomerular filtration rate (p= 0.0054; β= −0.1291) and coronary artery calcification (p= 0.0352; β= 1.1489) in the entire cohort. No significant associations were observed when individuals with T2D were analyzed separately. In individuals without T2D, increased circulating AGEs were associated with increased BMI (p= 0.02, β = 0.138), low density lipoproteins (p=0.046, β = 17.07) and triglycerides (p= 0.0004, β = 0.125), and decreased carotid artery calcification (p= 0.0004, β = −1.2632) and estimated glomerular filtration rate (p= 0.0018, β = −0.1405). Strong trends were also observed for an association between AGEs and poorer cognitive performance on the digit symbol substitution test (p=0.046, β = −6.64) and decreased grey matter volume (p=0.037, β = −14.87). Conclusions AGEs may play an important role in a number of phenotypes and diseases, although not necessarily in interindividual variation in people with T2D. Further evaluation of specific AGE molecules may shed more light on these relationships.

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Plasma advanced glycation end products (AGEs) and NF-κB activity are independent determinants of diastolic and pulse pressure

Cited by 16 publications

References 74 publications

Skin Autofluorescence and Pentosidine Are Associated With Aortic Stiffening

Skin Autofluorescence and Pentosidine Are Associated With Aortic Stiffening

Effect of dietary advanced glycation end products on inflammation and cardiovascular risks in healthy overweight adults: a randomised crossover trial

Analysis of advanced glycation end products in the DHS Mind Study

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