1989
DOI: 10.1507/endocrj1954.36.167
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Plasma Aldosterone Level in a Female Case of Pseudohyperaldosteronism (Liddle's Syndrome).

Abstract: A 22-yr-old female suffering from hypertension, hypokalemic alkalosis and suppressed plasma renin activity was studied. The plasma aldosterone concentration (PAC) ranged between subnormal and normal levels while the other adrenal mineralocorticoids were normal. Examinations through computed. tomography and ultrasonography showed no abnormal findings. For diferential diagnosis, dexamethasone, spironolactone and triamterene were administered. Triamterene alone corrected the abnormalities in this case, and the th… Show more

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Cited by 8 publications
(2 citation statements)
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“…Liddle syndrome is an autosomal dominant trait that is characterized by early onset of severe hypertension, hypokalemia, suppressed plasma renin activity, and low aldosterone levels [23]. However, besides these classical clinical and laboratory characteristics, patients may present atypically, without hypokalemia [24]or with normal plasma aldosterone levels, or may present with varying degrees of hypertension [24, 25, 26, 27, 28, 29]. Furthermore, suppression of renin is not an integral part of Liddle disease [23, 25, 28, 30], thus raising the possibility that Liddle syndrome is underdiagnosed.…”
Section: Discussionmentioning
confidence: 99%
“…Liddle syndrome is an autosomal dominant trait that is characterized by early onset of severe hypertension, hypokalemia, suppressed plasma renin activity, and low aldosterone levels [23]. However, besides these classical clinical and laboratory characteristics, patients may present atypically, without hypokalemia [24]or with normal plasma aldosterone levels, or may present with varying degrees of hypertension [24, 25, 26, 27, 28, 29]. Furthermore, suppression of renin is not an integral part of Liddle disease [23, 25, 28, 30], thus raising the possibility that Liddle syndrome is underdiagnosed.…”
Section: Discussionmentioning
confidence: 99%
“…The degree of hypertension is variable within kindreds and some members of families with the disorder have normal BP. The pedigree described by Liddle was Caucasian but there have been additional descriptions of Japanese families with the syndrome (250,370), in a Hispanic family (292) and in an African American kindred (102).…”
Section: Pseudoaldosteronism Liddle's Syndromementioning
confidence: 99%