Plasma amino acid concentrations throughout normal pregnancy and early stages of intrauterine growth restricted pregnancy

Giulio, Anna Maria Di; Carelli, Stephana; Castoldi, Roberto; Gorio, A.; Taricco, Emanuela; Cetin, Irene

doi:10.1080/14767050410001725578

Cited by 37 publications

(34 citation statements)

References 16 publications

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“…Our previous studies pointed to certain relationship between the amino acid levels in the blood plasma and brain [23], which may be used for translation of findings on the brain samples in animal models to human studies. For instance, increased content of tryptophan in cerebellum of pregnant rats, shown in our study (Table 1) corresponds to the findings in humans, which indicate that in maternal plasma, tryptophan catabolites and related compounds change in pregnancy [38,39]. This study suggests the neurotransmitters-dependent adaptation of maternal body to the fetus growth.…”

Section: Discussionsupporting

confidence: 88%

Hypoxic Adaptation of Mitochondrial Metabolism in Rat Cerebellum Decreases in Pregnancy

Граф

Trofimova

Ksenofontov

et al. 2020

Cells

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Function of brain amino acids as neurotransmitters or their precursors implies changes in the amino acid levels and/or metabolism in response to physiological and environmental challenges. Modelling such challenges by pregnancy and/or hypoxia, we characterize the amino acid pool in the rat cerebellum, quantifying the levels and correlations of 15 amino acids and activity of 2-oxoglutarate dehydrogenase complex (OGDHC). The parameters are systemic indicators of metabolism because OGDHC limits the flux through mitochondrial TCA cycle, where amino acids are degraded and their precursors synthesized. Compared to non-pregnant state, pregnancy increases the cerebellar content of glutamate and tryptophan, decreasing interdependence between the quantified components of amino acid metabolism. In response to hypoxia, the dependence of cerebellar amino acid pool on OGDHC and the average levels of arginine, glutamate, lysine, methionine, serine, phenylalanine, and tryptophan increase in non-pregnant rats only. This is accompanied by a higher hypoxic resistance of the non-pregnant vs. pregnant rats, pointing to adaptive significance of the hypoxia-induced changes in the cerebellar amino acid metabolism. These adaptive mechanisms are not effective in the pregnancy-changed metabolic network. Thus, the cerebellar amino acid levels and OGDHC activity provide sensitive markers of the physiology-dependent organization of metabolic network and its stress adaptations.

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Section: Discussionsupporting

confidence: 88%

Hypoxic Adaptation of Mitochondrial Metabolism in Rat Cerebellum Decreases in Pregnancy

Граф

Trofimova

Ksenofontov

et al. 2020

Cells

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“…Changes in plasma concentration of amino acids may play an important role in determining appropriate fetal growth. Consistent with reported changes in several amino acids found in pregnant mother (Di Giulio et al, 2004), many kinds of amino acids also demonstrated different degrees of deletion in our study. The decreased concentrations of some metabolites such as N-acetyl glycoprotein, creatine and creatinine related to the decomposition of the protein (Delanghe et al, 1989;Pinto et al, 2015).…”

Section: Protein Metabolismsupporting

confidence: 81%

1H NMR-based metabolomics study on the physiological variations during the rat pregnancy process

Shen

Zhang

et al. 2016

Molecular and Cellular Endocrinology

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a b s t r a c tIn this study, NMR-based metabolomics in combination with multivariate pattern recognition technologies were employed to evaluate the physiological variations in the Wistar rats' plasma that are induced by pregnancy on the gestational days (GDs) 11, 14, 17 and 20. Untargeted metabolomics analysis revealed some possible mechanism of physiological effects for healthy pregnancies and showed a metabolic trajectory during pregnancy process. The levels of 24 metabolites were found to change significantly throughout pregnancy in maternal plasma. These metabolite changes involved in varied kinds of metabolic pathways including synthesis of biological substances, microbial metabolism in diverse environments, protein digestion and absorption, carbohydrate metabolism, digestion and absorption, mineral absorption, and ATP (Adenosine Triphosphate)-binding cassette transporters (ABC transporters). The substantial cores of all the metabolic pathways are promoting fetal growth and development and regulating maternal physiological state. This work showed relevant metabolic pathways perturbation in the maternal plasma due to normal pregnancy and provided the physical basis of time-dependent metabolic trajectory against which disease-related maternal physiological responses may be better understood in future studies.

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“…It is thought that this indicates impaired uteroplacental adaptation to pregnancy, which may be an early step in the development of the condition. 14 The lower fetal amino acid concentrations in IUGR pregnancies are most probably the result of reduced transplacental transport. Several studies in both humans 15 16 and sheep 17 18 have shown lower in vivo placental transport of labelled amino acids in IUGR pregnancies than in AGA pregnancies.…”

Section: Fetal Growth and Metabolismmentioning

confidence: 99%

Protein metabolism in preterm infants with particular reference to intrauterine growth restriction

Boo

Harding

2007

Archives of Disease in Childhood - Fetal and Neonatal Edition

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Plasma amino acid concentrations throughout normal pregnancy and early stages of intrauterine growth restricted pregnancy

Cited by 37 publications

References 16 publications

Hypoxic Adaptation of Mitochondrial Metabolism in Rat Cerebellum Decreases in Pregnancy

Hypoxic Adaptation of Mitochondrial Metabolism in Rat Cerebellum Decreases in Pregnancy

1H NMR-based metabolomics study on the physiological variations during the rat pregnancy process

Protein metabolism in preterm infants with particular reference to intrauterine growth restriction

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