Plasma Amino Acids as Predictors of the Severity and Outcome of Sepsis

Freund, Herbert R.; Atamian, Susan; Holroyde, Jane; Fischer, Josef E.

doi:10.1097/00000658-197911000-00003

Cited by 208 publications

(95 citation statements)

References 10 publications

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“…Muscle-protein breakdown was increased in a pig model of sepsis with lowered arginine levels (Bruins et al 2002a), while in septic paediatric patients increased arginine oxidation was observed (Argaman et al 2003). The potential need for arginine supplementation is further strengthened by the observation that a marked reduction in serum arginine is a predictor of mortality in patients with sepsis (Freund et al 1979).…”

Section: Sepsismentioning

confidence: 99%

Pros and cons of L-arginine supplementation in disease

et al. 2004

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The amino acid arginine and one of its metabolites NO have gathered broad attention in the last decade. Although arginine is regarded as a conditionally essential amino acid in disease, L-arginine supplementation in severe illness has not found its way into clinical practice. This might be due to the invalid interpretation of results from studies with immune-enhancing diets containing L-arginine amongst other pharmaconutrients. However, not much attention is given to research using L-arginine as a monotherapy and the possibility of the alternative hypothesis: that L-arginine supplementation is beneficial in disease. The present review will discuss data from studies in healthy and diseased animals and patients with monotherapy of L-arginine to come to an objective overview of positive and negative aspects of L-arginine supplementation in disease with special emphasis on sepsis, cancer, liver failure and wound healing.

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Section: Sepsismentioning

confidence: 99%

Pros and cons of L-arginine supplementation in disease

et al. 2004

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“…The human body requires small amounts of it to function properly. On average, adults take in an estimated 60 micro gram of trivalent chromium every day with their food [42,43]. Chromium is distributed in oil seeds differently as the individual plant and discussed below.…”

Section: Comparison Of Metal Levels In This Study (Niger Seed) With Lmentioning

confidence: 99%

Nutrient composition of niger seed (Guizotia abyssinica (L. f.) Cass.) cultivated in different parts of Ethiopia

Syume¹,

Chandravanshi²

2015

Bull. Chem. Soc. Eth.

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ABSTRACT. The levels of essential and non-essential metals in niger seed (Guizotia abyssinica (L. f.) Cass.) cultivated in different parts of Ethiopia were determined by flame atomic absorption spectrometry after wet digestion using 2.5 mL of HNO3 (69.5%), 1 mL HClO4 (60%) and 0.5 mL of 30% H2O2 at 210 o C for 150 min. Sampling was carried out randomly from nine different sites from Ethiopia and one sample from Eretria for comparison. The following metal concentration ranges (μg/g) were determined in niger seed samples, respectively: Na (159-736), K (5594-8203), Ca (340-680), Mg (2404-4656), Mn (13.4-34.3), Fe (31.6-370), Cu (9.5-61.2), Zn (23.4-46.2), Cr (4.0-16.8), Co (4.9-27.3), Ni (13.0-32.4), Pb (15.5-19.3) and Cd was not detected in all the samples. The analysis of variance indicated the presence of significance difference at 95% confidence level among niger seeds collected from different sites. Pearson correlation coefficients indicated that there were significant correlations among some metals in the niger seed. The study revealed that niger seed is good source of essential metals and free from toxic metal such as Cd and hence safe for human consumption. Generally, the metal concentration in niger seed is comparable with other oil seeds.

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“…One of the possible suggestions to septic encephalopathy-induced abnormalities stems from amino acid derangements in septic patients (Freund HR et al, 1978). The altered patterns of plasma amino acids are well correlated between non-septic encephalopathy and severe septic encephalopathy groups (Freund H et al, 1979). For example, several amino acids including glutamate, aspartate and tryptophan are altered in septic encephalopathy patient.…”

Section: Septic Encephalopathymentioning

confidence: 99%