Plasma amino acids in preterm infants fed different human milk diets from a human milk bank

Santos, Sandra Christo dos; Figueiredo, Carmen Martimbianco de; Andrade, Sonia Maria Oliveira de; Palhares, Durval Batista

doi:10.1016/j.eclnm.2007.03.002

Cited by 6 publications

(3 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Data on the plasma of preterm infants fed with protein hydrolysate formulas, standard formula and fortified breast milk have shown that their enzymatic immaturity affects the amino acid (AA) concentrations, the net protein utilization and the total AA and energy intake, and that the quality of the proteins can also impact the plasma AA concentrations [ 34 , 35 , 36 , 37 ]. Furthermore, because of the immature renal tubular reabsorption of AAs, an excessive protein intake could be responsible for an increased excretion of these compounds in urine [ 38 ].…”

Section: Discussionmentioning

confidence: 99%

Urinary Metabolomic Profile of Preterm Infants Receiving Human Milk with Either Bovine or Donkey Milk-Based Fortifiers

Giribaldi¹,

Peila

Coscia

et al. 2020

Nutrients

View full text Add to dashboard Cite

Fortification of human milk (HM) for preterm and very low-birth weight (VLBW) infants is a standard practice in most neonatal intensive care units. The optimal fortification strategy and the most suitable protein source for achieving better tolerance and growth rates for fortified infants are still being investigated. In a previous clinical trial, preterm and VLBW infants receiving supplementation of HM with experimental donkey milk-based fortifiers (D-HMF) showed decreased signs of feeding intolerance, including feeding interruptions, bilious gastric residuals and vomiting, with respect to infants receiving bovine milk-based fortifiers (B-HMF). In the present ancillary study, the urinary metabolome of infants fed B-HMF (n = 27) and D-HMF (n = 27) for 21 days was analyzed by 1H NMR spectroscopy at the beginning (T0) and at the end (T1) of the observation period. Results showed that most temporal changes in the metabolic responses were common in the two groups, providing indications of postnatal adaptation. The significantly higher excretion of galactose in D-HMF and of carnitine, choline, lysine and leucine in B-HMF at T1 were likely due to different formulations. In conclusion, isocaloric and isoproteic HM fortification may result in different metabolic patterns, as a consequence of the different quality of the nutrients provided by the fortifiers.

show abstract

Section: Discussionmentioning

confidence: 99%

Urinary Metabolomic Profile of Preterm Infants Receiving Human Milk with Either Bovine or Donkey Milk-Based Fortifiers

Giribaldi¹,

Peila

Coscia

et al. 2020

Nutrients

View full text Add to dashboard Cite

show abstract

“…However, the enzymatic immaturity of preterm neonates makes them more prone to deficiencies or to toxicity deriving from any excess of amino acids than full-term neonates [39]. There is a decrease in protein contents in mature milk while the needs for proteins of preterm neonates remain high, resulting in the inappropriateness of that nutrient to supply such need.…”

Section: A-dmentioning

confidence: 99%

The Impact of the Block Freeze Concentration Process on Human Milk Properties Intended for Feeding Newborns

Berenhauser¹,

Canella²,

Muñoz³

et al. 2017

FNS

View full text Add to dashboard Cite

Human milk is the ideal nutritional support for premature neonates. Considering the need for aggregating nutritional value to human milk provided to such vulnerable group of infants, human milk was concentrated by the block freeze concentration technique. The effects of freeze concentration on the physicochemical properties, the efficiency of the process, color parameters, and the density and dynamic viscosity of human milk were assessed. The freeze concentration technology was used to successfully concentrate human milk to a factor equal to 180.48% and 72% of total solid retention in the second stage of freeze concentration. The values observed in the concentrates for the biochemical properties showed that the fraction of concentrated fluid human milk of the second stage (C2) presented elevated amounts of carbohydrates, protein and energy. The elevated caloric value observed in the ice fraction of the first stage (I1) refers to the retention of lipids in it. When added to human milk, C2 and I1 may satisfy the special requisites of nutrients and energy to guarantee the growth and development of preterm neonates.

show abstract

“…O acréscimo de fortificantes ao leite humano proveniente da própria mãe ou de banco de leite se faz necessário [6][7][8] . Considerando que a qualidade da proteína do leite humano é considerada a ideal para os recém-nascidos, o uso de aditivos cuja proteína seja de origem homóloga parece ser o mais adequado 9 .…”

Section: Introductionunclassified

Comparison between homologous human milk supplements and a commercial supplement for very low birth weight infants

et al. 2012

View full text Add to dashboard Cite

Objectives: To describe the methodology for the preparation of two additives derived from human milk, liquid and powdered, and to compare this composition with the commercial additive FM85 ® . Methods:For the preparation of the liquid and powdered supplements, 40 samples of human milk were used. Both supplements have been through three preparation phases: skimming, evaporation and lactose removal. After these phases, the liquid supplement is ready, and the powdered requires a fourth phase -lyophilization. To each sample of the liquid and powdered supplements were added, respectively, 80 mL (group I) and 100 mL (group II) of pooled banked human milk. For comparison, 20 samples of 100 mL of the pool were added to 5 g of the FM85 ® supplement (Nestlé) (group III). Analyses of carbohydrates, protein, lipids, calcium, phosphorus, sodium, osmolality and caloric content were performed, considering a significant difference p < 0.05. Results Conclusion:The studied additives differ significantly from the commercial additive FM85 ® in some of its components, and its composition may or may not meet the quantity of nutrients suggested by the most recent recommendations. J Pediatr (Rio J). 2012;88(2):119-24:Premature infant, enteral nutrition, human milk, milk bank. ResumoObjetivos: Descrever a metodologia de preparo de dois aditivos, líquido e em pó, derivados do leite humano e comparar a constituição com aditivo comercial FM85 ® . Métodos:Foram utilizadas 40 amostras de leite humano para o preparo dos suplementos líquido e em pó. Ambos passaram por três fases de preparo: desnate, evaporação e retirada da lactose. Após essas fases, o suplemento líquido está pronto, e o em pó necessita da quarta fase -a liofilização. Em cada amostra dos suplementos líquido e em pó, foram adicionados, respectivamente, 80 mL (grupo I) e 100 mL (grupo II) de pool de leite humano de banco. Para comparação, 20 amostras de 100 mL do pool foram acrescidas de 5 g do suplemento FM85 ® (Nestlé) (grupo III). Realizaram-se análises de hidratos de carbono, proteína, lipídios, cálcio, fósforo, sódio, osmolalidade e conteúdo calórico, considerando diferença significativa p < 0,05. Conclusão:Os aditivos estudados diferem significativamente do aditivo comercial FM85 ® em alguns de seus constituintes, e a sua constituição pode ou não atender às quantidades de nutrientes propostas pelas recomendações mais recentes. J Pediatr (Rio J)

show abstract

Plasma amino acids in preterm infants fed different human milk diets from a human milk bank

Cited by 6 publications

References 15 publications

Urinary Metabolomic Profile of Preterm Infants Receiving Human Milk with Either Bovine or Donkey Milk-Based Fortifiers

Urinary Metabolomic Profile of Preterm Infants Receiving Human Milk with Either Bovine or Donkey Milk-Based Fortifiers

The Impact of the Block Freeze Concentration Process on Human Milk Properties Intended for Feeding Newborns

Comparison between homologous human milk supplements and a commercial supplement for very low birth weight infants

Contact Info

Product

Resources

About