1985
DOI: 10.1192/bjp.147.3.276
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Plasma Amino Acids in Relation to Cerebrospinal Fluid Monoamine Metabolites in Schizophrenic Patients and Healthy Controls

Abstract: Compared to healthy controls, unmedicated schizophrenic patients had significantly higher plasma concentrations of taurine, methionine, valine, isoleucine, leucine, phenylalanine, and lysine. Except for taurine, these amino acids share the L-transport system for neutral amino acids. In the patients, homovanillic (HVA) acid levels in CSF were decreased and the plasma levels of the amino acids competing with tyrosine and tryptophan for transport into the brain, were all negatively correlated to the CSF concentra… Show more

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Cited by 111 publications
(68 citation statements)
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“…There have also been a number of studies examining the effects of chronic SSRI treatment on human lumbar CSF 5-HIAA levels. These studies have consistently reported declines of CSF 5-HIAA of 40-60% after weeks or months of SSRI administration (Bjerkenstedt et al, 1985;Potter et al, 1985;Scheinin, 1985;Martensson et al, 1991;De Bellis et al, 1993;Sheline et al, 1997). It is worth noting that the magnitude of the typical 5-HIAA decrease observed in human subjects is similar to that seen after acute SSRI administration in animals.…”
Section: Introductionmentioning
confidence: 60%
“…There have also been a number of studies examining the effects of chronic SSRI treatment on human lumbar CSF 5-HIAA levels. These studies have consistently reported declines of CSF 5-HIAA of 40-60% after weeks or months of SSRI administration (Bjerkenstedt et al, 1985;Potter et al, 1985;Scheinin, 1985;Martensson et al, 1991;De Bellis et al, 1993;Sheline et al, 1997). It is worth noting that the magnitude of the typical 5-HIAA decrease observed in human subjects is similar to that seen after acute SSRI administration in animals.…”
Section: Introductionmentioning
confidence: 60%
“…A total of 20 studies on peripheral glutamate levels in schizophrenia were identified. Of these, three studies were excluded because healthy controls were not included in the study design [13,14,20], three studies were excluded because mean glutamate levels were not reported [14,21,22] and a further three studies were excluded because measurements were taken from the CSF rather than the blood [8,15,23]. In addition, one study was excluded because the full text of the paper could not be accessed [24].…”
Section: Resultsmentioning
confidence: 99%
“…This hypofunction was suggested as a potential factor in schizophrenia development by studies reporting lower levels of amine neurotransmitter metabolites for the disorder including: (a) some schizophrenics had defi cits in CSF HVA (a DA metabolite) [68][69][70][71] , (b) a subgroup of schizophrenics with abnormal auditory brainstem-evoked responses had signifi cantly lower CSF levels of HVA than normals [72] , (c) a subgroup of schizophrenics with enlarged cerebral ventricles had signifi cantly lower CSF levels of 5-HIAA (a 5-HT metabolite) [73] , and (d) based on family studies, a subtype of schizophrenia was defi ned that was characterized by low levels of CSF 5-HIAA and HVA [74,75] .…”
Section: Discussionmentioning
confidence: 99%