Plasma and CSF oxytocin levels after intranasal and intravenous oxytocin in awake macaques

Freeman, Sara M.; Samineni, Sridhar; Allen, Philip C.; Stockinger, Diane E; Bales, Karen L.; Hwa, Granger G.C.; Roberts, Jeffrey A.

doi:10.1016/j.psyneuen.2016.01.014

Cited by 119 publications

(93 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Recently, Neumann and colleagues (2013) used microdialysis in rats to demonstrate that IP administration of oxytocin caused rapid peak levels in brain dialysates 30 min post injection, providing direct evidence that systemic oxytocin increases central oxytocin levels. Consistently, intravenous oxytocin (5 IU/kg) increased oxytocin levels in cerebral spinal fluid, peaking at 15 min post-dose and gradually returning to baseline by 120 min in rhesus macaques (Freeman et al, 2016). However, it does remain unclear how peripheral administration of oxytocin propagates central oxytocin function because Lee et al (2017) demonstrated that oxytocin administered through intranasal and intravenous administration increased oxytocin in cerebral spinal fluid, but did not activate a feed forward mechanism to elevate endogenous oxytocin.…”

Section: Discussionmentioning

confidence: 88%

Antagonism of mGlu2/3 receptors in the nucleus accumbens prevents oxytocin from reducing cued methamphetamine seeking in male and female rats

Bernheim

Leong

Berini

et al. 2017

Pharmacology Biochemistry and Behavior

View full text Add to dashboard Cite

Methamphetamine (meth) addiction is a prevalent health concern worldwide, yet remains without approved pharmacological treatments. Preclinical evidence suggests that oxytocin may decrease relapse, but the neuronal underpinnings driving this effect remain unknown. Here we investigate whether oxytocin’s effect is dependent on presynaptic glutamatergic regulation in the nucleus accumbens core (NAcore) by blocking metabotropic glutamate receptors 2/3 (mGluR2/3). Male and female Sprague-Dawley rats self-administered meth or sucrose on an escalating fixed ratio, followed by extinction and cue-induced reinstatement sessions. Reinstatement tests consisted of systemic (Experiment 1) or site-specific application of the drugs into the NAcore (Experiments 2 and 3). Before reinstatement sessions, rats received LY341495, an mGluR2/3 antagonist, or its vehicle followed by a second infusion/injection of oxytocin or saline. As expected, both males and females reinstated lever pressing to meth associated cues, and LY341495 alone did not impact this behavior. Oxytocin injected systemically or infused into the NAcore decreased cued meth seeking. Importantly, combined LY341495 and oxytocin administration restored meth cued reinstatement. Interestingly, neither oxytocin nor LY341495 impacted sucrose-cued reinstatement, suggesting distinct mechanisms between meth and sucrose. These findings were consistent between males and females. Overall, we report that oxytocin reduced responding to meth-associated cues and blocking presynaptic mGluR2/3 reversed this effect. Further, oxytocin’s effects were specific to meth cues as NAcore oxytocin was without an effect on sucrose cued reinstatement. Results are discussed in terms of oxytocin receptor localization in the NAcore and modulation of presynaptic regulation of glutamate in response to drug associated cues.

show abstract

Section: Discussionmentioning

confidence: 88%

Antagonism of mGlu2/3 receptors in the nucleus accumbens prevents oxytocin from reducing cued methamphetamine seeking in male and female rats

Bernheim

Leong

Berini

et al. 2017

Pharmacology Biochemistry and Behavior

View full text Add to dashboard Cite

show abstract

“…Microdialysis studies in rats show simultaneous release of OT in the hypothalamus and blood during nursing (Neumann, Ludwig, Engelmann, Pittman, & Landgraf, 1993). Both plasma and CSF OT levels increase after intranasal and intravenous exogenous OT administration in primates (Dal Monte, Noble, Turchi, Cummins, & Averbeck, 2014; Freeman et al, 2016) and humans (Striepens et al, 2013), so there is evidence that the central and peripheral OT systems communicate with and respond to each other. In animal models, the central and peripheral OT systems can communicate with each other and influence behavior through afferent inputs, including the vagal nerve (Brown, Bains, Ludwig, & Stern, 2013).…”

Section: Discussionmentioning

confidence: 99%

Plasma and Urinary Oxytocin Trajectories in Extremely Premature Infants During NICU Hospitalization

Weber

Harrison

Sinnott

et al. 2017

Biological Research For Nursing

View full text Add to dashboard Cite

Extremely premature infants are at great risk for poor neurodevelopmental outcomes, in part because neurologic structures designed to mature in the womb must now do so in the extrauterine environment. Reliable biomarkers of neurodevelopment are especially critical in this population, as behavioral measures can be unreliable due to immaturity of the premature infant nervous system. Oxytocin (OT) has the potential to be a marker of neurobiological processes that offer infant neuroprotection. However, no studies have measured OT in the plasma and urine of premature infants. The purposes of this study were to describe plasma and urine OT levels of premature infants through 34 weeks corrected gestational age (CGA), determine whether plasma and urine OT are correlated, and explore associations between infant demographics and OT trajectories. Plasma and urine from 37 premature infants, born at gestational ages 25–28 6/7 weeks, were longitudinally collected at 14 days of life, then weekly until 34 weeks CGA. Plasma OT decreased with age, at a rate of 15% per week, and exhibited strong stability within infants. Urine OT was not correlated with plasma OT and did not show a significant trend over time; thus, urine may not be a reliable, noninvasive measurement in this population. Apgar score was the only infant demographic characteristic associated with plasma OT. Given the novelty of this work, replication is needed to confirm these findings, and future research should explore potential mechanisms (e.g., stress, normal maturation, and social experiences) that contribute to declining plasma OT levels in premature infants.

show abstract

“…Moreover, OB cells also express OXTRs [108] and VP receptors [109] while circulating neuropeptides are less likely acting on the HNS [110]. Thus, the OB could be the first brain target of nasally-applied neuropeptides and can be the only direct target if these neuropeptide doses are lower enough [111][112]. Relative to the extensively identified brain effects of nasally-applied OXT, the effects of nasal VP are relatively weak and limited [113] and thus, exploring OXT-associated OB-SON pathway likely provides a useful model to study the mechanism underlying the actions of intranasal neuropeptides.…”

Section: Nose-hns Route Mediating Nasal Drug Effects On Brain Activitiesmentioning

confidence: 99%

Model Roles of the Hypothalamo-Neurohypophysial System in Neuroscience Study

Hou¹,

Feng²,

Li³

et al. 2016

Biochem Pharmacol (Los Angel)

View full text Add to dashboard Cite

Plasma and CSF oxytocin levels after intranasal and intravenous oxytocin in awake macaques

Cited by 119 publications

References 36 publications

Antagonism of mGlu2/3 receptors in the nucleus accumbens prevents oxytocin from reducing cued methamphetamine seeking in male and female rats

Antagonism of mGlu2/3 receptors in the nucleus accumbens prevents oxytocin from reducing cued methamphetamine seeking in male and female rats

Plasma and Urinary Oxytocin Trajectories in Extremely Premature Infants During NICU Hospitalization

Model Roles of the Hypothalamo-Neurohypophysial System in Neuroscience Study

Contact Info

Product

Resources

About