Plasma and erythrocyte uptake of omega-3 fatty acids from an intravenous fish oil based lipid emulsion in patients with advanced oesophagogastric cancer

Eltweri, A.; Thomas, Anne; Fisk, Helena L.; Arshad, Ali; Calder, Philip C.; Dennison, Ashley R.; Bowrey, David J.

doi:10.1016/j.clnu.2016.06.001

Cited by 18 publications

(16 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Using standard laboratory techniques, routine clinical variables of interest were measured including C-reactive protein (CRP), selenium, zinc, copper, folate, vitamin B12 and vitamin D. Vitamin B6 concentrations were measured by high performance liquid chromatography with fluorescence detection as previously described [32]. Erythrocyte fatty acid levels were measured using a Hewlett Packard 6890 gas chromatograph (HewlettePackard; Avondale, PA, USA), as previously described [33]. Fatty acids are expressed as weight % of total fatty acids present.…”

Section: Blood Analysismentioning

confidence: 99%

Characterising the nutritional status of children with primary ciliary dyskinesia

et al. 2019

Self Cite

View full text Add to dashboard Cite

We have characterised the nutritional phenotype of a cohort of children with PCD. Monitoring vitamin D levels is important in PCD patients. There is a weak association between lung function and nutritional status, and measures of BIS phase-angle. The use of BIS phase-angle may allow for early identification of at risk children and may therefore be of benefit for nutritional assessments in the clinical setting. These findings will help inform a future nutritional intervention strategy in children with PCD.

show abstract

Section: Blood Analysismentioning

confidence: 99%

Characterising the nutritional status of children with primary ciliary dyskinesia

et al. 2019

Self Cite

View full text Add to dashboard Cite

show abstract

“…This study aimed to assess the effect of administering intravenous ω-3FAs in combination with gemcitabine chemotherapy on EPCs in patients with APC compared to gemcitabine monotherapy alone. Previous published data have demonstrated that intravenous administration of ω-3FAs is well tolerated (23), results in rapid uptake into cell membranes and improves patient's quality of life (24)(25)(26)(27)(28) in advanced cancers. This study has some limitations.…”

Section: Discussionmentioning

confidence: 99%

Endothelial Progenitor Cells are Increased in Patients with Advanced Pancreatic Cancer Treated with Gemcitabine and Intravenous Omega 3 Compared with Controls

Isherwood

Arshad

Chung

et al. 2020

Preprint

View full text Add to dashboard Cite

Abstract Introduction Pancreatic adenocarcinoma (PAC) is a devastating disease. Endothelial progenitor cells (EPCs) are important mediators in PAC. Omega 3 fatty acids (ω-3FAs) have been shown to have anti-inflammatory properties. Methods This was a single centre study investigating intravenous ω-3FAs and gemcitabine chemotherapy versus gemcitabine therapy alone in patients with APC. The primary outcome measure was the level of EPCs with the secondary outcome measure being the relationship between the EPC levels, progression free survival and overall survival.Results Over the treatment period CD45-, CD31+, CD133+ EPCs and CD45-, CD31+, CD34+ EPCs significantly increased (P=O.O42 and P=0.0001), whilst no change was observed in control EPCs (P=0.705). There was a non-significant downward trend in control EPCs (P=0.930, 95%). There was a significant difference between the trial and control patients over time on logistic regression analysis (P=0.0001). There was a significant increase in CD45-, CD34+, CD31+ and CD133+ EPCs trial EPCs over treatment (P=0.007). There was no significant increase seen in control EPCs (P=0.358, 95%). There was a significant difference between the trial and control patients over treatment on logistic regression analysis (P=0.0001). There was a significant correlation in the trial patients between progression free survival benefit and an increase in EPCs.Conclusion Intravenous ω-3FAs with gemcitabine chemotherapy in APC results in a significantly increased level of EPCs. There appears to be a survival benefit in patients with an increase in EPCs which may be the result of a reduction in pro-inflammatory mediators.

show abstract

“…Plasma membrane flexibility is maintained by achieving a better balance between oxidants and antioxidants, and is important for cell function (Hollán 1996;Moffarts et al 2007). In this context, the inclusion of dietary oil may support a higher concentration of omega 3 and 6 fatty acids in the membranes of erythrocytes and leukocytes, thus stabilizing the plasma cell membranes and offsetting the antioxidant effects caused by different sources (Barros et al 2013;Eltweri et al 2017). The stabilization of these cell membranes supports not only oxygen transport through the erythrocytes but may also contribute to the immune system by stabilizing the leukocyte cell membranes.…”

Section: Discussionmentioning

confidence: 99%

Use of oil-rich diet for gaited horses during physical training

et al. 2019

View full text Add to dashboard Cite

In Brazil, gaited horses are selected based on field tests, during which they move at speeds of 3 to 4 m/s for 30 to 60 min. To cover their nutrient requirements, feed manufacturers have developed oil-rich dietary supplements and concentrates. The aim of this research was to evaluate the effects of increasing the density of dietary fats in the feed of 16 Campolina horses undergoing intense gaited training. The training schedule consisted of training 4 × a week: 3 days riding for 60 min (10' warm-up, 40' doing marcha gait, and 10' cool down, and 1 day walking for 90'). The horses were divided in two groups: control and supplemented. The dietary supplementation was isocaloric, with the control group receiving an ordinary concentrate (3.5% fat) and the supplemented group fed 1.0 kg of the supplement (18% fat) plus the ordinary concentrate. Both groups had free access to fresh grass, salt and water. Blood samples were collected prior to and after 4 and 8 weeks of supplementation to calculate the complete blood count, glucose, total protein, triglycerides, total cholesterol, HDL, LDL and non-esterified fatty acids (NEFA). The results were evaluated by ANOVA and Tukey's test (P < 0.05). The supplemented group showed elevated levels of NEFA, red blood cells and haematocrit (P < 0.05), while the control group showed high triglyceride concentrations; both groups showed reduced plasma protein concentrations (P < 0.05). The other indices did not change (P > 0.05). The increase in dietary fat intake increased the blood lipid biomarkers and antioxidant capacity of gaited horses during intense training, possibly contributing to improve their metabolic performance.

show abstract

Plasma and erythrocyte uptake of omega-3 fatty acids from an intravenous fish oil based lipid emulsion in patients with advanced oesophagogastric cancer

Abstract: 30Background: It has been demonstrated that short term intravenous (IV)

Cited by 18 publications

References 42 publications

Characterising the nutritional status of children with primary ciliary dyskinesia

Characterising the nutritional status of children with primary ciliary dyskinesia

Endothelial Progenitor Cells are Increased in Patients with Advanced Pancreatic Cancer Treated with Gemcitabine and Intravenous Omega 3 Compared with Controls

Use of oil-rich diet for gaited horses during physical training

Contact Info

Product

Resources

About