Plasma and erythrocyte ω-3 and ω-6 fatty acids are associated with multiple inflammatory and oxidative stress biomarkers in breast cancer

Lira, Letícia Gomes; Justa, Rute Mattos Dourado Esteves; Carioca, Antônio Augusto Ferreira; Verde, Sara Maria Moreira Lima; Sampaio, Geni Rodrigues; Torres, Elizabeth Aparecida Ferraz da Silva; Damasceno, Nágila Raquel Teixeira

doi:10.1016/j.nut.2018.07.115

Cited by 13 publications

(6 citation statements)

References 42 publications

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“…However, glycerophospolipids containing w-6 fatty acids were not statistically different in the three groups ( Figure 5B). The w-6/w-3 ratio was positively correlated with inflammation and oxidative stress (Lira et al, 2018). In the present study, the w-6/w-3 ratio (ratio of glycerophospholipids containing w-6 fatty acids to glycerophospholipids containing w-3 fatty acids) of model group dramatically increased than that in control group and EEOS group ( Figure 5C).…”

Section: Fatty Acids Composition In Glycerophospholipidssupporting

confidence: 58%

Lipidomics Reveals the Therapeutic Effects of EtOAc Extract of Orthosiphon stamineus Benth. on Nephrolithiasis

Chao

Gao

et al. 2020

Front. Pharmacol.

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Background: Nephrolithiasis is a systemic metabolic disease with a high prevalence worldwide and is closely related to lipid-mediated oxidative stress and inflammation. Orthosiphon stamineus Benth. (OS) is a traditional medicinal herb mainly containing flavonoids, caffeic acid derivatives, and terpenoids, which has the effect of treating urinary stones. However, the active ingredients of OS for the treatment of kidney stones and their regulatory mechanisms remain unknown. As a powerful antioxidant, flavonoids from herbs can mitigate calcium oxalate stone formation by scavenging radical. Thus, this work focused on EtOAc extract of OS (EEOS, mainly flavonoids) and aimed to reveal the potential intrinsic mechanism of EEOS in the treatment of kidney stones disease. Methods: Firstly, 75% ethanol extract of OS was further extracted with EtOAc to obtain EtOAc extract containing 88.82% flavonoids. Secondly, the extract was subjected to component analysis and used in animal experiments. Then, an untargeted lipidomics based on ultrahigh performance liquid chromatography coupled with TripleTOF 5600 mass spectrometer (UPLC-QTOF-MS) was performed to test the lipid changes of kidneys in the control group, model group and EEOS treatment groups. Finally, multivariate statistical analysis was used to identify differences between the lipid profiles of mice in the model group and the EEOS group. Results: Fifty-one lipid metabolites were significantly different between the mice in the model group and the EEOS intervention group, including glycerophosphocholines, glycerophosphoethanolamines, glycerophosphoinositols, and glycerophosphoglycerols. And the composition of glycerophospholipids-esterified w-3 polyunsaturated fatty acids and glycerophospholipid subclasses in the kidneys of the EEOS group significantly changed compared to model group. Conclusions: The EEOS can inhibit the stones formation by improving oxidative stress and inflammation mediated by glycerophospholipid metabolism. This study reveals the

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Section: Fatty Acids Composition In Glycerophospholipidssupporting

confidence: 58%

Lipidomics Reveals the Therapeutic Effects of EtOAc Extract of Orthosiphon stamineus Benth. on Nephrolithiasis

Chao

Gao

et al. 2020

Front. Pharmacol.

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“…Another in vivo experiment noted that ω-3 PUFAs play an antioxidant role in immortalized mouse Schwann cells through nuclear factor-related factor 2 pathway 27 . Furthermore, studies exploring the relationship between plasma PUFAs and biomarkers of oxidative stress of breast cancer found that ω-PUFAs can modulate the critical processes of breast carcinogenesis with oxidation and inflammation 28 .…”

Section: Discussionmentioning

confidence: 99%

Erythrocyte ω-3 polyunsaturated fatty acids are inversely associated with the risk of oral cancer: a case-control study

et al. 2020

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Objectives Evidence about ω-3 polyunsaturated fatty acids (ω-3 PUFAs) and oral cancer risk were limited. We aimed to evaluate the association of erythrocyte ω-3 PUFAs with the risk of oral cancer in a population from China. Methods Erythrocyte ω-3 PUFAs of 236 oral cancer patients and 300 controls were determined by gas chromatography. Restricted cubic spline and logistic regression were used to analyze the association between erythrocyte ω-3 PUFAs and oral cancer risk. The crude and adjusted OR with 95% CI was calculated. Stratification analysis was performed to explore the potential interaction between ω-3 PUFAs and other traditional risk factors such as smoking and drinking. Results Eicosapentaenoic acids (EPA), docosahexaenoic acids (DHA) and ω-3 index were negatively but non-linearly related to risk of oral cancer as observed by restricted cubic spline. The adjusted OR of EPA, DHA, and ω-3 index were 0.52 (95% CI: 0.35–0.76), 0.19 (95% CI: 0.08–0.44), 0.20 (95% CI: 0.09–0.44), respectively. Stratification analysis showed that the adverse correlation between EPA and oral cancer was only significant in the non-smoking group, while the adverse correlation of ɑ-linolenic acid (ALA), EPA, and DHA were only significant in the non-drinking group. General multiplicative interactions were observed between ω-3 PUFAs and smoking or drinking. Conclusions Adverse but non-linear associations were observed between erythrocyte EPA, DHA, ω-3 index, and oral cancer risk. Additionally, there were multiplicative interactions between ω-3 PUFAs and other behavior factors such as smoking and drinking. The protective effect of ω-3 PUFAs maybe more significant in the non-smoking or non-drinking population.

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“…10 A low adiponectin concentration was associated with a poor prognosis in early and/or newly diagnosed breast cancer. 43,44 Studies have also indicated that the adiponectin levels are directly associated with high-risk pattern mammograms and a high breast density in obese postmenopausal women. 45 High adiponectin levels were significantly associated with a lower breast density in Mexican premenopausal women, but these women were not overweight or obese.…”

Section: Dovepressmentioning

confidence: 99%

Effect of Metformin on Breast Density in Overweight/Obese Premenopausal Women

Leng

Jiang

et al. 2021

DMSO

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Plasma and erythrocyte ω-3 and ω-6 fatty acids are associated with multiple inflammatory and oxidative stress biomarkers in breast cancer

Cited by 13 publications

References 42 publications

Lipidomics Reveals the Therapeutic Effects of EtOAc Extract of Orthosiphon stamineus Benth. on Nephrolithiasis

Lipidomics Reveals the Therapeutic Effects of EtOAc Extract of Orthosiphon stamineus Benth. on Nephrolithiasis

Erythrocyte ω-3 polyunsaturated fatty acids are inversely associated with the risk of oral cancer: a case-control study

Effect of Metformin on Breast Density in Overweight/Obese Premenopausal Women

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