Plasma and jejunal glutamine levels after extensive small bowel resection in dogs

Astre, C.; Gouttebel, M. C.; Saint-Aubert, B.; Girardot, Pierre Marie; Joyeux, H

doi:10.1016/0261-5614(92)90060-4

Cited by 5 publications

(2 citation statements)

References 15 publications

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“…Hct values of group A, B and C were significantly lower than control at different intervals. Similar results were reported by Astre et al [1]. Granulocytic count of group A and C was significantly higher than control at different intervals.…”

Section: Discussionsupporting

confidence: 91%

Effect of variable degrees of jejunal resection upon different clinico-biochemical parameters in dogs

Dilawer¹,

Khan²,

Abidin³

et al. 2011

Korean J Vet Res

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Dogs are considered to be the best companions of human beings due to their loyalty, obedience and pleasant disposition. Jejunum is the largest part of small intestine mainly involved in absorption of nutrients. Jejunal resection up to 80% allows normal weight gain while resection up to 90% increased morbidity and mortality. In the present study, 20 dogs were divided into 4 groups based on the degree of jejunal resection i.e. A (70% resection), B (80% resection) and C (100% resection) while group D served as control. Dogs in the 70% and 80% jejunal resection group showed normal growth and function while 100% jejunal resection resulted in weight loss and alteration of hematological and biochemical parameters.

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Section: Discussionsupporting

confidence: 91%

Effect of variable degrees of jejunal resection upon different clinico-biochemical parameters in dogs

Dilawer¹,

Khan²,

Abidin³

et al. 2011

Korean J Vet Res

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“…It is also an important metabolic fuel for rapidly dividing cells, including the small intestinal mucosa, and after small bowel resection, glutamine released from muscle stores is taken up by the gut. 23 Supplementing parenteral nutrition fluids with glutamine reduces the gastrointestinal atrophy seen during parenteral nutrition2425 and the severity of the mucosal injury after chemotherapy or radiation treatment. 26 Glutamine provided enterally may enhance postresection adaptation.…”

Section: Control Of Postresection Adaptation2mentioning

confidence: 99%

Enteral nutrition as primary therapy in short bowel syndrome.

Booth

1994

Gut

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The spectacular success of parenteral nutrition in supporting patients during small intestinal adaptation after massive resection, tends to obscure the prolonged periods often needed for such adaptation to take place. After neonatal small intestinal resection for example, it may take more than five years before adaptation is complete. There is therefore a strong argument for examining ways in which adaptation can be facilitated, in particular, by the addition of novel substrates to enteral feeds. Pectin is completely fermented by colonic bacteria to short chain fatty acids. In the rat, addition of pectin to enteral feeds led to a more rapid adaptive response in both the small and large intestine after massive small intestinal resection, although faecal nitrogen losses were increased.

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Influence of glutamine-supplemented parenteral nutrition on intestinal amino acid metabolism in rats after small bowel resection

et al. 1996

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Glutamine (Gln)-supplemented total parenteral nutrition (TPN) has been shown to improve mucosal adaptation after massive small bowel resection (SBR); however, its influences on intestinal amino acid metabolism remain unknown. In this study, intestinal amino acid flux, circulating plasma aminogram, mucosal glutaminase activity and protein, and DNA content were measured 7 days after massive SBR in rats receiving either standard (Std) or Gln-supplemented TPN. Sham-operated rats and rats fed chow after enterectomy served as controls. The uptake of Gln and the release of citrulline (Cit) by the remaining intestine was significantly decreased, with reduced mucosal glutaminase activity after SBR in the Chow and Std-TPN groups. Glutamine supplementation resulted in significantly increased gut Gln uptake compared with Std-TPN (P < 0.01). Mucosal glutaminase activity, mucosal protein, and DNA content was also increased by Gln; however, the gut release of Cit remained unchanged (P > 0.05). The subsequent decrease in circulating arginine (Arg) in the Gln-TPN group compared with the Std-TPN group (P < 0.05) was attributed to an insufficient exogenous supply. These findings show that Gln-supplemented TPN improves mucosal growth and gut Gln uptake after SBR. However, the intestinal production of Cit, which remained low in both TPN groups, may lead to an insufficiency of endogenous Arg synthesis. Thus, both Gln and Arg may be essential amino acids after SBR.

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Plasma and jejunal glutamine levels after extensive small bowel resection in dogs

Cited by 5 publications

References 15 publications

Effect of variable degrees of jejunal resection upon different clinico-biochemical parameters in dogs

Effect of variable degrees of jejunal resection upon different clinico-biochemical parameters in dogs

Enteral nutrition as primary therapy in short bowel syndrome.

Influence of glutamine-supplemented parenteral nutrition on intestinal amino acid metabolism in rats after small bowel resection

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