Plasma and pituitary concentrations of LH, FSH and prolactin in aged female C57BL/6 mice

Parkening, T. A.; Collins, Thomas J.; Smith, Edward

doi:10.1530/jrf.0.0580377

Cited by 70 publications

(26 citation statements)

References 40 publications

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“…These results are similar to those in the previous report of Nobunaga et al for IV CS mice [17] and also, with those previously described in other mouse strains : C 57 BL/6 [18] ; C 5 7 BL/6J [5,16]. The increased incidence of abnormal estrous cycles in aging mice may indicate changes in ovarian function, particularly in the secretion of estradiol [6,14].…”

Section: Discussionsupporting

confidence: 92%

Changes in the Estrous Cycle and Number of Ovulated and Fertilized Ova in Aging Female IVCS Mice

Tappa

Amao

Ogasa

et al. 1989

Experimental Animals

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IV CS mice (ddN origin) aged 90 days (control) and 180, 210, 240, 270, 300, 330, 360 and 420 days were used for observation of the length of the estrous cycle, and the numbers of ovulated and fertilized ova. The estrous cycle between the ages of 90 and 330 days presented a regular 4-day pattern.Thereafter, regularity of the cycle declined steadily between the ages of 360 and 420 days. All mice over 420 days old exhibited cessation of cyclicity and ultimately persistent diestrus. The average number of ova ovulated in mice aged between 90 and 240 days was consistent (11.8 to 11.4 ova), whereas a steady decline was observed for mice between 270 days old (10.5 ova) and 360 days old (4.8 ova). Ova were not recovered from oviducts of mice aged about 420 days. The average number of fertilized ova (2-cell stage) in mice between 90 and 210 days old showed no significant change(11.5 to 10. 3), whereas the number began to decrease in mice aged between 240 days (8.7 fertilized ova) and 330 days (2.5 fertilized ova). No fertilized ova were recovered from the oviducts of mice around 360 days old. These findings demonstrate that the decline of reproductive activity is initially observed in the number of fertilized ova, followed by a decline in the number of ovulations and finally by loss of the estrous cycle.

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Section: Discussionsupporting

confidence: 92%

Changes in the Estrous Cycle and Number of Ovulated and Fertilized Ova in Aging Female IVCS Mice

Tappa

Amao

Ogasa

et al. 1989

Experimental Animals

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“…HUANG et al (1978) demonstrated that none of the elderly female rats, in contrast to the young rats, showed signs of a cyclic change in LB and FSH levels. PARKENING et al (1980) showed that the pituitary and plasma levels of LB and FSH were increased in the aged female mouse. The increase in LB content in the aged female is the same as our finding in aged rats, but the FSH levels remained unchanged in our results.…”

Section: Discussionmentioning

confidence: 99%

Immunoelectron Microscopic Studies of Gonadotrophs in the Male and Female Rat Anterior Pituitaries, with Special Reference to their Changes with Aging.

Kurosumi

Ozawa

Akiyama

et al. 1991

Arch. Histol. Cytol.

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Summary.Gonadotrophs immunocytochemically identified with an antibody to LH/3 were studied in both male and female rats of various ages, viz., 2,14 and 23 months after birth. The rat gonadotrophs are classified into two cell types, i.e., Type I containing large (300-700 nm) and small Gonadotropins secreted by the anterior pituitaries of mammals are known to consist of two hormones, viz. the follicle-stimulating hormone (FSH) and luteinizing hormone (LH). In early morphological studies using either the light or electron microscope, gonadotropinproducing cells also divided into two types, suggesting that one might produce FSH and the other might produce LH (PURVES and GRIESBACH, 1954;FARQUHAR andRINEHART, 1954, 1955;BARNES, 1963;KUROSUMI and OOTA, 1968).BARNES (1963) demonstrated FSH cells and LH cells in the mouse anterior pituitary, and showed that the secretory granules of FSH cells were less electron dense than those of LH cells. KUROSUMI and OOTA (1968) found two groups of secretory granules, large and small, in rat presumptive FSH cells, but only small secretory granules in the putative LH cells. In mouse gonadotrophs, large secretory granules were not observed by BARNES (1963), though other morphological characteristics of rat and mouse FSH cells were identical. Immunohistochemistry at the light microscopic level revealed that most gonadotrophic cells in rat (NAKANE, 1970) and man (PHIFER et al., 1973) pituitaries contain both FSH and LH, though a few cells contain only one of these gonadotropins. Because of the colocalization of FSH and LH in some gonadotrophs, KUROSUMI (1974) renamed the previous FSH and LH cells Type I and Type II gonadotrophs, respectively. The authors use this classification here; that is, the Type I gonadotroph contains large and small secretory granules, while the Type II cell contains only small granules.As most typical gonadotrophs in the male rat pituitary that correspond to Type I gonadotrophs contain both LH and FSH in the same cell, the subcellular distribution of the two hormones required clarification. INOUE and KUROSUMI (1984) studied the immunoelectron microscopic localization of LB and 559

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“…Plasma prolactin (PRL) levels were determined by radioimmunoassay (RIA) using materials provided by Dr. Y.N. Sinha, as described previously [17][18][19]. The levels of luteinizing hormone (LH).…”

Section: Measurement Ofhco Binding and Hormonesmentioning

confidence: 99%

Hormonal Regulation of Testicular Human Chorionic Gonadotropin Binding and Steroidogenesis in Adult Mice with Different Forms of Hereditary Diabetes and Obesity

et al. 1986

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The regulation of testicular hCG binding and steroidogenesis in adult mutant mice with hereditary diabetes and obesity was studied. Low doses of hCG caused no change in hCG binding in obese (ob/ob) mice, whereas, in diabetic (db/db) mice, the increase in binding measured 24 h after hCG administration was not as great as in normal males. Intermediate doses of hCG caused a decrease in hCG binding in obese and normal mice, but not in diabetic animals. However, 72 h after injection of intermediate doses of hCG, a decrease in hCG binding also was observed in diabetic mice. Plasma testosterone was elevated 24 h after hCG injection in all types of mice studied, but the increase in diabetic mice was smaller than in normal animals. However, 72 h after treatment with hCG, plasma testosterone was still elevated in diabetic mice, but not in normal males. In vitro, hCG stimulated testicular testosterone synthesis in all groups of mice, but the observed increase was smaller in diabetic and obese than in normal animals. Plasma LH levels were higher in diabetic than in normal mice, whereas plasma FSH and prolactin levels were lower in obese mice than in normal animals. All parameters (i.e., LH receptors and circulating hormone levels) measured in yellow (A^y/a) mice were similar to those in normal (a/a) mice. The present study indicates that in these models for noninsulin-dependent diabetes, the testicular metabolism of LH receptors and capacity to secrete steroids is altered.

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Plasma and pituitary concentrations of LH, FSH and prolactin in aged female C57BL/6 mice

Cited by 70 publications

References 40 publications

Changes in the Estrous Cycle and Number of Ovulated and Fertilized Ova in Aging Female IVCS Mice

Changes in the Estrous Cycle and Number of Ovulated and Fertilized Ova in Aging Female IVCS Mice

Immunoelectron Microscopic Studies of Gonadotrophs in the Male and Female Rat Anterior Pituitaries, with Special Reference to their Changes with Aging.

Hormonal Regulation of Testicular Human Chorionic Gonadotropin Binding and Steroidogenesis in Adult Mice with Different Forms of Hereditary Diabetes and Obesity

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