Plasma and tissue kinetics of enrofloxacin and its metabolite, ciprofloxacin, in yellow catfish (Pelteobagrus fulvidraco) after a single oral administration at different temperatures

Xu, Ning; Sun, Weiyu; Zhang, Huan; Liu, Yongtao; Dong, Jing; Zhou, Shun; Yang, Yibin; Yang, Qiuhong; Ai, Xiaohui

doi:10.1016/j.cbpc.2023.109554

Cited by 4 publications

(4 citation statements)

References 41 publications

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“…Additionally, this study supported that this tilmicosin lead to inhibition was greatly associated with CYP3A4 in animal and in vitro (Zhang et al, 2022). Recent study confirmed that enerofloxacin and ciprofloxacin are tendency to accumulate in liver rather than other organ as skin, muscle and kidney (Xu et al, 2023). Here, we investigated the effects of berberine on the activity of enerofloxacin as well as interactions between berberine and enrofloxacin in liver and muscle residual.…”

Section: Histopathological Studysupporting

confidence: 74%

Effect of Berberine on Some Histopathological, Enrofloxacin Residue and Aniti-Diarrheaginic Escherichia coli in Broilar Chicken

Rabee,

Abdulameer,

Obed

et al. 2023

AAVS

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Background Antibiotic residues in poultry have the potential to have a number of harmful effects on health, including the emergence of multidrug-resistant microbial strains, allergic and an alteration of the normal flora in the intestines. The study aimed to evaluate the residue levels of enrofloxacin in chicken meat after administering berberine (BBR). Escherichia coli (E. coli) was isolated from chickens suffering from diarrhea, and its isolation was confirmed by culturing it on MacConkey agar medium. In this study, a total of one hundred chicken chicks were reared, and on the tenth day of the experiment, they were divided into five equal groups:NCG: This group represented the control and was given normal drinking water. T1: The chickens in this group were orally inoculated with E. coli at a dose of 0.5 ml containing 6x108 CFU/ml of E. coli. T2: The chickens in this group were orally inoculated with E. coli at a dose of 0.5 ml containing 6x108 CFU/ml of E. coli and were treated with enrofloxacin at a dose of 12.5 mg/kg orally through drinking water. T3 group: The chickens in this group were orally inoculated with E. coli at a dose of 0.5 ml containing 6x108 CFU/ml of E. coli and were treated with 250 mg/kg BBR through drinking water. T4 group: The chickens in this group were orally inoculated with E. coli at a dose of 0.5 ml containing 6x108 CFU/ml of E. coli and were treated with both combination enrofloxacin and BBR. Conclusion: study showed that berberine increased the residue levels of enrofloxacin in chicken meat, specifically in the thigh and liver. The docking study confirmed inhibitory activity of Cytochrome P450 3A4 (CYP3A4) and P-glycoprotein (P-gp) an enzyme responsible for the metabolism of antibiotics. Additionally, berberine demonstrated antibacterial effects against E. coli, as well as anti-inflammatory and antioxidant properties. Furthermore, histopathological examination of the intestinal broiler received BBR showed improvements and restore tissue near to normal.

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Section: Histopathological Studysupporting

confidence: 74%

Effect of Berberine on Some Histopathological, Enrofloxacin Residue and Aniti-Diarrheaginic Escherichia coli in Broilar Chicken

Rabee,

Abdulameer,

Obed

et al. 2023

AAVS

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“…The approaches of sample preparation and determination of high-performance liquid chromatography (HPLC) were consistent with our previous study. The detailed procedures were referred to the reference [ 16 , 17 ].…”

Section: Methodsmentioning

confidence: 99%

The Assessment of Withdrawal Interval for Enrofloxacin in Yellow Catfish (Pelteobagrus fulvidraco) after Multiple Oral Administrations at Disparate Temperatures

Sun

Zhang

et al. 2023

Animals

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The objective of the present study was to investigate the residue depletion of EF and CF in yellow catfish to estimate its WTs in plasma and tissues after multiple oral doses for 3 days at 20 mg/kg at 15, 20, and 25 °C. Samples were collected at pre-designed time points after oral doses. A validated method was performed to quantify EF and CF in plasma and tissues by high-performance liquid chromatography. Statistical differences were conducted using one-way ANOVA analysis. According to the maximum residue limit of China and Europe considering 95% percentile with 95% confidence, the WTs were estimated to be 44, 72, 66, 99, and 95 days at 15 °C; 32, 66, 65, 86, and 73 days at 20 °C; and 32, 61, 64, 55, and 59 days at 25 °C in the plasma, muscle and skin, gill, liver, and kidney, respectively. We found that increased temperature shortened the WTs in plasma and tissues. Therefore, this study can help the risk assessment of EF in aquatic products for human health at different temperatures to avoid residue violation.

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“…As for the samples of plasma, 0.1 mL of plasma was decanted into a 10 mL centrifugation tube. The extraction method is the same as the reported literature [28].…”

Section: Sample Preparationmentioning

confidence: 99%

“…The HPLC method was validated by the linearity, recovery, precision, specificity, limit of detection (LOD), and limit of quantification (LOQ). The detailed procedures are according to the published references [28][29][30].…”

Section: Hplc Analysis and Validationmentioning

confidence: 99%

Effects of Temperature on Plasma Protein Binding Ratios (PPBRs) of Enrofloxacin and Ciprofloxacin in Yellow Catfish (Pelteobagrus fulvidraco), Grass Carp (Ctenopharyngodon idella), and Largemouth Bass (Micropterus salmoides)

Sun

Zhang

et al. 2023

Animals

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The objective of this study was to investigate the PPBRs of EF and CF in the plasma of yellow catfish, grass carp, and largemouth bass at different temperatures with different concentrations. A fast and simple ultrafiltration method was used to determine the PPBRs of EF and CF. Results showed that PPBRs of EF decreased from 37.71% to 9.66%, from 46.10% to 13.52%, and from 43.90% to 4.36% in the plasma of yellow catfish with the increase of concentration from 15 to 25 °C. The same trends of PPBRs of EF were presented in the plasma of grass carp and largemouth bass. In comparison to the data at the same concentration of EF at disparate temperatures, the PPBRs of EF at a concentration of 1 µg/mL increased from 37.71% to 46.10% and then decreased to 43.90% in the plasma of yellow catfish with elevated temperature from 15 to 25 °C. There is no obvious regularity with the rise of temperature, and the same phenomenon also were found in other concentrations and species. Meanwhile, the PPBRs of CF also decreased in the three species with the rise in concentration. Under the consistent concentration, the temperature-dependent regularities were not found in the PPBRs of CF. Overall, the increased concentration reduced the PPBRs of EF and CF in the plasma of three fish species, and the alteration in temperature only has a certain effect on the PPBRs of EF and CF.

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Plasma and tissue kinetics of enrofloxacin and its metabolite, ciprofloxacin, in yellow catfish (Pelteobagrus fulvidraco) after a single oral administration at different temperatures

Cited by 4 publications

References 41 publications

Effect of Berberine on Some Histopathological, Enrofloxacin Residue and Aniti-Diarrheaginic Escherichia coli in Broilar Chicken

Effect of Berberine on Some Histopathological, Enrofloxacin Residue and Aniti-Diarrheaginic Escherichia coli in Broilar Chicken

The Assessment of Withdrawal Interval for Enrofloxacin in Yellow Catfish (Pelteobagrus fulvidraco) after Multiple Oral Administrations at Disparate Temperatures

Effects of Temperature on Plasma Protein Binding Ratios (PPBRs) of Enrofloxacin and Ciprofloxacin in Yellow Catfish (Pelteobagrus fulvidraco), Grass Carp (Ctenopharyngodon idella), and Largemouth Bass (Micropterus salmoides)

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