Plasma and Urinary Follicle-Stimulating Hormone Levels in Oligospermia

Leonard, John M.; Leach, Robert B.; Couture, Margaret; Paulsen, C. Alvin

doi:10.1210/jcem-34-1-209

Cited by 86 publications

(30 citation statements)

References 1 publication

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“…There are no sexually unique hormones, although there are wide variations in the secretion of hormones related to reproduction. Evidence for inhibin in the male is accumulating (29)(30)(31)(32), and it has been invoked to account for high levels of FSH and normal levels of LH in oligospermic males (33)(34)(35), after testicular irradiation and after cvtotoxic chemotherapy (36,37).…”

Section: Resultsmentioning

confidence: 99%

Hormonal characteristics of the human menstrual cycle throughout reproductive life.

Sherman¹,

Korenman²

1975

J. Clin. Invest.

531

158

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A B S T R A C T The changes in serum levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), estradiol, and progesterone that occur both early and late in reproductive life were characterized and compared with findings in young, normal women and in patients with certain menstrual disorders.A total of 50 complete menstrual cycles in 37 women were examined. Five distinct patterns of hormonal regulation were found, three of which are reported here: (a) A long follicular phase and delayed follicular maturation in young women with long, unpredictable intermenstrual intervals from menarche; (b) a short follicular phase with increasing age and in short cycles in perimenopausal women; and (c) true anovulatory vaginal bleeding in long cycles in perimenopausal women.The short cycles before and during the menopausal transition were found to have lower E2 levels and high FSH concentrations throughout, while LH remained in the normal range. During long cycles in perimenopausal women, concentrations of LH and FSH were in the menopausal range. However, follicular maturation was observed months after high levels of gonadotropins were attained.These studies permit the characterization of the menstrual history of the normal woman in terms of the hormonal changes that occur and provide a basis for the definition of several disorders of follicular maturation.

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Section: Resultsmentioning

confidence: 99%

Hormonal characteristics of the human menstrual cycle throughout reproductive life.

Sherman¹,

Korenman²

1975

J. Clin. Invest.

531

158

View full text Add to dashboard Cite

show abstract

“…He postulated that some interaction between the Sertoli cells and the more mature spermatogenic cells is of major importance in the maintenance of high levels of the FSH inhibitor. In contrast, Leonard, Leach, and Paulsen failed to demonstrate any correlation between sperm count and serum FSH levels in normal men (21). Elevated FSH levels have been found in some patients with idiopathic oligospermia (21-23), however, Leonard et al could show no differences in germinal cell numbers between men with normal and those with elevated FSH titers.…”

Section: Introductionmentioning

confidence: 90%

Evidence for a Specific Seminiferous Tubular Factor Affecting Follicle-Stimulating Hormone Secretion in Man

Thiel¹,

Sherins²,

Myers³

et al. 1972

J. Clin. Invest.

193

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A B S T R A C T The interaction of the testis and gonadotropin secretion was studied in 15 men surviving chemotherapy for lymphoma. Azoospermia and complete destruction of all testicular germinal elements were present in 10 of the 15 men; however, Sertoli cells and Leydig cells were present. In these 10 men plasma follicle-stimulating hormone (FSH) levels were fourfold higher than in normal men of similar age whereas luteinizing hormone (LH) levels were normal. In contrast, both FSH and LH were normal in the remaining five men. Three had a full complement of spermatogenic tissue on biopsy and normal sperm concentrations. The other two men were azoospermic; one demonstrated full spermatogenesis in 30% of his tubules; the other had only a few spermatogonia in all tubules. In those patients with lower levels of gonadotropins pituitary insufficiency was excluded by the demonstration of appropriate responsiveness of FSH and LH to clomiphene administration. Similarly, Leydig cell function was normal since plasma testosterone was within the normal range in 13 of the 15 men and only slightly decreased in two. Thus, following chemotherapy, testicular damage was restricted to the germinal tissue, and this in turn was associated with a selective increase in FSH. The source of the FSH inhibitor is either the Sertoli cell or early germinal elements. However, since FSH levels are only half as high as those reported for castrate men, other testicular factors may modify FSH secretion.

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“…Variable, even contradictory, results obtained from investigations of idiopathic oligozoospermia [10,11], varying therapeutic results with different treatment re gimes, and absence of well-established evaluation criteria suggest that more than a single factor effect the pathogen esis of idiopathic oligozoospermia.…”

Section: Discussionmentioning

confidence: 99%

Seminal Transferrin Levels in Seminal Plasma of Fertile and Infertile Men

Çek¹,

Cûrgûl²,

Ertaş³

et al. 1992

Urol Int

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Seminal plasma transferrin levels as well as serum FSH and LH levels were measured in fertile (normozoospermic) and infertile (oligozoospermic and azoospermic) men in an effort to find out whether transferrin levels correlated with sperm density and serum FSH and LH levels. Seminal plasma transferrin levels were found to be significantly lower (p < 0.0005) in the infertile group than the fertile group. Seminal plasma transferrin levels can be regarded as a functional parameter of Sertoli cell function in men.

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Plasma and Urinary Follicle-Stimulating Hormone Levels in Oligospermia

Cited by 86 publications

References 1 publication

Hormonal characteristics of the human menstrual cycle throughout reproductive life.

Hormonal characteristics of the human menstrual cycle throughout reproductive life.

Evidence for a Specific Seminiferous Tubular Factor Affecting Follicle-Stimulating Hormone Secretion in Man

Seminal Transferrin Levels in Seminal Plasma of Fertile and Infertile Men

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