Plasma and Urinary Heart-Type Cytoplasmic Fatty Acid-Binding Protein in Coronary Occlusion and Reperfusion Induced Myocardial Injury Model

Sohmiya, Koichi; Tanaka, Takao; Tsuji, Ryoichi; Yoshimoto, Kenro; Nakayama, Yasushi; Hirota, Yuzo; Kawamura, Keishiro; Matsunaga, Yoshimasa; Nishimura, Shinzo; Miyazaki, Hisashi

doi:10.1006/jmcc.1993.1158

Cited by 39 publications

(19 citation statements)

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“…It did not mention the survival prognosis, so this study is the first report on survival prognosis using H-FABP. Because a good correlation of the myocardial infarct size with H-FABP level has been documented in previous studies (4,5), it is reasonable that H-FABP is correlated with the prognosis in patients with AMI. But in our study, H-FABP was also correlated with the prognosis in patients excluding AMI (n=534).…”

Section: Discussionmentioning

confidence: 70%

“…H-FABP occurs in part in skeletal muscles as well, and its content in the myocardium is reportedly 3 to 10 times as high as in the skeletal muscle (1,2). H-FABP became recognized as a cardiac marker in the 1990s (3)(4)(5)(6). Troponin and CK-MB isozyme have been reported to be of low diagnostic sensitivity for early after onset of acute myocardial infarction (AMI), their approximate diagnostic sensitivity being 20% at 2 hours, 40% at 4 hours, and 60% at 6 hours after the onset (7,8).…”

Section: Introductionmentioning

confidence: 99%

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Relationship between Heart-Type Fatty Acid-Binding Protein Levels and the Risk of Death in Patients with Serious Condition on Arrival at the Emergency Department

et al. 2005

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Objective Although heart-type fatty acid-binding protein (H-FABP) is a cardiac marker useful for early diagnosis of acute myocardial infarction (AMI), few data are available on its prognostic value. The objective of this study is to clarify the prognostic value of H-FABP in patients with a serious condition. Methods and PatientsWe conducted a prospective study of 617 patients who presented to the emergency department with a serious condition. The H-FABP levels on arrival at the emergency department were divided into four groups using their quartiles. The endpoint was death from any causes in-hospital.Results H-FABP ranged from 1.2 to 2,300 ng/ml, with a median of 19.9 ng/ml, a 25%-value of 6.7 ng/ml and 75%-value of 54.0 ng/ml. The unadjusted rate of the mortality increased progressively with increasing H-FABP quartile point (11% for quartile-I, 22% for quartile-II, 36% for quartile-III, and 38% for quartile-IV; p<0.001). After adjustment for age, gender, systolic blood pressure and the presence or absence of cardiovascular disease, H-FABP was the independent factor to predict the mortality.Conclusion H-FABP has proven to be an independent factor for prognosis in patients with a serious condition on arrival at the emergency department. (Internal Medicine 44: 1039-1045, 2005)

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Section: Discussionmentioning

confidence: 70%

Section: Introductionmentioning

confidence: 99%

Relationship between Heart-Type Fatty Acid-Binding Protein Levels and the Risk of Death in Patients with Serious Condition on Arrival at the Emergency Department

et al. 2005

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“…Further investigations are required to explore the application of this approach to a broad spectrum of patients presenting with chest pain and a low to intermediate probability of ACS. Because H-FABP has a very low molecular mass, its elimination rate is partly determined by the patient's kidney function (19 ). It would be interesting to determine whether our findings might apply to patients with chronic renal failure.…”

Section: Discussionmentioning

confidence: 94%

Prognostic Value of Serum Concentration of Heart-Type Fatty Acid–Binding Protein Relative to Cardiac Troponin T on Admission in the Early Hours of Acute Coronary Syndrome

Ishii

Ozaki

et al. 2005

Clinical Chemistry

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Background: Heart-type fatty acid-binding protein (H-FABP) is proposed as an early biomarker for acute myocardial infarction (AMI), but its prognostic value is unclear in acute coronary syndrome (ACS). We evaluated the prognostic value of the H-FABP concentration relative to cardiac troponin T (cTnT) in the early hours of ACS. Methods: Serum concentrations of H-FABP and cTnT were measured on admission in 328 consecutive patients hospitalized for ACS within 6 h after the onset of chest pain [AMI, 241 (73.5%) patients; ST-segment elevation myocardial infarction, 154 (47.0%) patients; and emergent coronary angiography within 24 h after admission, 287 (87.5%) patients]. Cardiac events, which were defined as cardiac death or subsequent nonfatal AMI, were monitored for 6 months after admission. Results: During the 6-month follow-up period, there were 25 cardiac events, including 15 cardiac deaths and 10 subsequent nonfatal AMIs. Stepwise multivariate analyses including clinical, electrocardiographic, and biochemical variables revealed that increased H-FABP (above the median of 9.8 g/L), but not increased cTnT (above the median of 0.02 g/L), was independently associated with

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“…The increase in urine concentration was detected within 1.5 h after the symptom onset [66]. Different animal studies have been performed to investigate the concentration curves of hFABP in the urine [30, 40, 79]. The results showed that hFABP was diagnostic of AMI only after 30 min of coronary artery ligation.…”

Section: Hfabp In Acute Myocardial Infarctionmentioning

confidence: 99%

“…Several clinical observations indicate that this protein is mainly eliminated trough the kidney. hFABP is detected in the urine of patients soon after onset of symptoms [40]. …”

Section: Hfabpmentioning

confidence: 99%

Heart Fatty Acid Binding Protein in the Diagnosis of Myocardial Infarction: Where Do We Stand Today?

Colli¹,

Josa²,

Pomar³

et al. 2006

Cardiology

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Heart fatty acid binding protein (hFABP) is a novel small cytosolic protein that is abundant in the heart. It is highly cardiac-specific (i.e. expressed primarily in cardiac tissue), but is also expressed at low concentrations in tissues outside the heart. After myocardial ischemic damage, hFABP can be detected in the blood as early as 1–3 h after onset of chest pain, with peak values reached at 6–8 h and plasma levels returning to normal within 24–30 h. hFABP’s clinical diagnostic value is very limited in the presence of renal failure and skeletal muscle diseases as it is completely renally eliminated. In these conditions, the diagnosis of acute myocardial infarction (AMI) may be overestimated. The combination of initial hFABP release after symptom onset, rapid kidney clearance from the circulation and high cardiac specificity suggests great potential for clinical use. Serial measurements of hFABP in the first 24 h after onset of symptoms in AMI patients can: (a) identify patients who are susceptible to reperfusion strategies, (b) detect perioperative AMIs, (c) distinguish patients who reperfuse their infarct-related artery from those who do not, as early as 30 min after starting thrombolytic treatment, (d) detect re-infarction if it occurs within 10 h after symptom onset, and (e) permit an accurate estimation of myocardial infarct size providing important prognosis information.

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Plasma and Urinary Heart-Type Cytoplasmic Fatty Acid-Binding Protein in Coronary Occlusion and Reperfusion Induced Myocardial Injury Model

Cited by 39 publications

References 0 publications

Relationship between Heart-Type Fatty Acid-Binding Protein Levels and the Risk of Death in Patients with Serious Condition on Arrival at the Emergency Department

Relationship between Heart-Type Fatty Acid-Binding Protein Levels and the Risk of Death in Patients with Serious Condition on Arrival at the Emergency Department

Prognostic Value of Serum Concentration of Heart-Type Fatty Acid–Binding Protein Relative to Cardiac Troponin T on Admission in the Early Hours of Acute Coronary Syndrome

Heart Fatty Acid Binding Protein in the Diagnosis of Myocardial Infarction: Where Do We Stand Today?

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