Plasma and Whole Blood Viscosity Changes in Shock and after Dextran Infusion

Yao, See Tao; Shoemaker, William C.

doi:10.1097/00000658-196612000-00006

Cited by 20 publications

(7 citation statements)

References 8 publications

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“…These results are compatible with the observations of Gelin, Brunius, Fritjofsson, and Lewis (25) who, using the Xe1 method, demonstrated that LMWD could increase the renal blood flow and the urine flow in the dog, despite maintained hypotension. Among other considerations, the lowering of the blood viscosity (26) and the antithrombotic effect of LMWD may preserve a high velocity of the microvascular flow under those conditions. The intravascular thromboses observed in the preceding groups were never observed on the histologic section of kidneys from animals reinfused with LMWD.…”

Section: Resultsmentioning

confidence: 99%

Effect of retransfusion after hemorrhagic hypotension on intrarenal distribution of blood flow in dogs

Carrière¹,

Daigneault²

1970

J. Clin. Invest.

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A B S TRA CT Hemorrhagic hypotension in anesthetized dogs produces a marked decrease of the cortical blood flow, whereas the medullary blood flow is well preserved. These animals were maintained at blood pressures of 50 mm Hg during a 3 hr period after which their blood pressures were restored by the reinfusion of blood or dextran, or both. In the first group of animals, the reinfusion of blood reestablished the blood pressure to control values, but the cortical blood flow was still nonuniformly decreased whereas the medullary blood flow appeared to be increased. In the second group of animals, phenoxybenzamine failed to protect the kidney completely since after blood reinfusion, the same anomalies described for the preceding group were found in 7 out of 10 dogs. The animals of the third group were reinfused with 50% of the shed blood and 10 ml/kg of a 10 g/100 ml solution of low molecular weight dextran. The modifications of the intrarenal distribution of the blood flow were less marked in this group although the blood flow rate of the inner cortex and the outer medulla was always elevated under these conditions. The reinfusion of low molecular weight dextran alone (20 ml/kg of a 10 g/100 ml solution) restored the blood pressure to levels slightly lower than those observed under control conditions but reestablished a normal pattern of intrarenal blood flow. The reinfusion of high molecular weight dextran was inefficient in correcting completely the anomalies of the renal blood flow. Mechanisms such as the increased sympathetic tone, the liberation of angiotensin, and the intravascular cellular aggregation could possibly account

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Section: Resultsmentioning

confidence: 99%

Effect of retransfusion after hemorrhagic hypotension on intrarenal distribution of blood flow in dogs

Carrière¹,

Daigneault²

1970

J. Clin. Invest.

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“…There have been reports in recent years of an abnormally high blood viscosity in various circulatory disorders such as shock (Yao and Shoemaker, 1966), diabetes (Skovborg et al, 1966), coronary disease (Gregerson et al, 1963;Mayer, 1964Dintenfass et al, 1966, and peripheral arterial disease (Dormandy, 1970). Underlying such a connexion is the assumption of an inverse relationship between blood viscosity and blood flow.…”

Section: Discussionmentioning

confidence: 99%

Influence of Blood Viscosity on Blood Flow and the Effect of Low Molecular Weight Dextran

Dormandy¹

1971

BMJ

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“…Several careful investigations show that raised blood viscosity from various causes (trauma, blood loss, endotoxin, experimentally used high molecular dextran) can be reduced by infusion of dextran 40 in animals and humans [127,393,501,502,511,745,1258,1308,1337,1562,1607,1613,1748]. See Fig.…”

Section: M) Influence On Viscositymentioning

confidence: 99%

Blood Replacement

Gruber¹

1969

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All rights reserved. No part of this book may be translated or reproduced in any form withoutwritten permission from Springer-Verlag. © by Springer-Verlag Berlin Heidelberg 1969. Library of Congress Catalog Card Number 69-16845Softcover reprint of the hardcover 1st edition 1969The use of general descriptive names, trade marks, etc. in this publication, even if the former are not especially identified, is not be taken as a sign that such names, as understood by the Trade Marks and Merchandise Act, may accordingly be used freely by anyone. Title-No. 1551 Dedicated to my wife LisaEs wurde fertig in Deiner Hut. Bleib Du mir auf dieser Erden, so 5011 alles fertig werden. THOMAS MANN ForewordThe manifold problems of shock are still of great importance, diagnostic and therapeutic experience of the "severely ill" being supplied with new information almost every month. In the 5 periodicals which have found their way to my desk during the past few days there are no less than 10 interesting articles on questions concerning shock research [see Bibliography 41 b, 53 a, 60 a, 192 a, 242 a, 350 b, 810 a, 941 a, 1069 a, 1082 a]. The most urgent point still is to maintain as complete as possible the objective catalog of the various shock manifestations found in man and in animals -yet at the same time to view interpretations of these phenomena in their relative and temporal "truth".Problems of shock research are not only interesting for their scientific value but also for their clinical implication. In particular, almost every practicing physician is facing problems of blood replacement very frequently. The effective or circulating blood volume remains an important theoretical and therapeutic problem in the shock field. For years, U. F. GRUBER has pursued this question clinically and experimentally. This volume deals with the world literature in an exceptionally thorough manner. This book is made more than a compilation by including a long list of original work done with F. D. MOORE in Boston, in the Surgical Department in Chur, with L. E. GELIN and S. E. BERGENTZ in Goteborg and in the Laboratory for Experimental Surgery in Davos; judgements are made on the basis of original studies, and essential points are separated from unimportant ones. This volume will be welcomed by the medical profession because it carefully treats vital questions concerning this complicated, much-discussed, and in part contested field, considering that today, along with various forms of blood and several plasma preparations, there are more than 40 different plasma replacement substances available with various physico-chemical, biological and pharmacological properties. Older preparations have been abandoned, others modified, and new ones appear.A comparative evaluation of the chemical characteristics, the range of indication and the therapeutic effectiveness of these solutions suggests itself particularly at this time because in recent years the use of large amounts of balanced electrolyte solutions tended to reverse the principles of blood replaceme...

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Plasma and Whole Blood Viscosity Changes in Shock and after Dextran Infusion

Cited by 20 publications

References 8 publications

Effect of retransfusion after hemorrhagic hypotension on intrarenal distribution of blood flow in dogs

Effect of retransfusion after hemorrhagic hypotension on intrarenal distribution of blood flow in dogs

Influence of Blood Viscosity on Blood Flow and the Effect of Low Molecular Weight Dextran

Blood Replacement

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