Plasma antibodies to oral bacteria and risk of pancreatic cancer in a large European prospective cohort study

Michaud, Dominique S.; Izard, Jacques; Wilhelm-Benartzi, Charlotte S.; You, Doo Ho; Grote, Verena A.; Tjønneland, Anne; Dahm, Christina C.; Overvad, Kim; Jenab, Mazda; Fedirko, Veronika; Boutron-Ruault, Marie Christine; Clavel‐Chapelon, Françoise; Racine, Antoine; Kaaks, Rudolf; Boeing, Heiner; Foerster, Jana; Trichopoulou, Antonia; Λάγιου, Παγώνα; Trichopoulos, Dimitrios; Sacerdote, Carlotta; Sieri, Sabina; Palli, Domenico; Tumino, Rosario; Panico, Salvatore; Siersema, Peter D.; Peeters, Petra H.M.; Lund, Eiliv; Barricarte, Aurelio; Huerta, José María; Molina‐Montes, Esther; Dorronsoro, Miren; Quiŕos, J. Ramón; Duell, Eric J.; Ye, Weimin; Sund, Malin; Lindkvist, Björn; Johansen, Dorthe; Khaw, Kay Tee; Wareham, Nick; Travis, Ruth C.; Víneis, Paolo; Bueno-De-Mesquita, H. Bas; Riboli, Elio

doi:10.1136/gutjnl-2012-303006

Cited by 339 publications

(353 citation statements)

References 53 publications

Supporting

Mentioning

335

Contrasting

Unclassified

Order By: Relevance

“…In a recent retrospective case-control study, oral bacteria measures in saliva were associated with pancreatic cancer [48]. Michaud et al [1] found increased levels of antibodies against specific commensal oral bacteria, which can inhibit growth of pathogenic bacteria and might reduce the risk of pancreatic cancer. The possible mechanisms include Toll-like receptor signaling, nitrosamine exposure and increase of systemic inflammation [49].…”

Section: Oral Microbiota and Pancreatic Cancermentioning

confidence: 99%

“…Multiple observations have shown that oral microbiota overlap with the digestive tract microbiota, providing multiple avenues for dissemination in dysbiosis [1]. In a recent retrospective case-control study, oral bacteria measures in saliva were associated with pancreatic cancer [48].…”

Section: Oral Microbiota and Pancreatic Cancermentioning

confidence: 99%

“…Each year, approximately 40,000 Americans die of pancreatic cancer, making it the fourth most common cause of cancer-related mortality [1]. The survival time of pancreatic cancer is very short, with fewer than half of patients surviving past 6 months from diagnosis.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Pathogenic Microorganisms and Pancreatic Cancer

Wang

2015

Gastrointest Tumors

View full text Add to dashboard Cite

Background: Pancreatic cancer is one of the most lethal cancers worldwide. No effective screening methods exist, and available treatment modalities do not effectively treat the disease. Established risk factors for pancreatic cancer, including smoking, chronic pancreatitis, obesity and type 2 diabetes mellitus, collectively account for less than half of all pancreatic cancer cases. Accumulating reports have demonstrated that there is an association between pathogenic microorganisms and pancreatic cancer. Summary: A substantial amount of preclinical and clinical evidence suggests that microbiota are likely to influence pancreatic carcinogenesis. This review summarizes the literature on studies examining infections that have been linked to pancreatic cancer. Key Message:Helicobacter pylori infection may be a risk factor for pancreatic cancer; chronic hepatitis virus and oral microbiota may also play a role in pancreatic carcinogenesis. Practical Implications: Considering the worldwide burden of the disease, the association between microbiota and pancreatic cancer in this review may provide new ideas to prevent and treat pancreatic cancer more efficiently. Further studies in this direction are urgently needed.

show abstract

Section: Oral Microbiota and Pancreatic Cancermentioning

confidence: 99%

Section: Oral Microbiota and Pancreatic Cancermentioning

confidence: 99%

See 1 more Smart Citation

Pathogenic Microorganisms and Pancreatic Cancer

Wang

2015

Gastrointest Tumors

View full text Add to dashboard Cite

show abstract

“…This result may support the idea that periodontal diseases increase the risk of pancreatic cancer. 15 Their study also reported that higher serum levels of P. gingivalis (ATCC 53978) may be the best marker for the higher burden of the bacteria and invasive periodontal diseases which may justify why this bacterium is the only periodontal pathogen possibly correlated with higher risk of pancreatic cancer. Also, a recent study compared the saliva samples of healthy individuals and those with pancreatic cancer patients and reported that there was a significant relationship between higher prevalence of P. gingivalis and this type of cancer.…”

Section: Discussionmentioning

confidence: 98%

The prevalence rate of Porphyromonas gingivalis and its association with cancer: A systematic review and meta-analysis

Sayehmiri

Asadollahi

et al. 2015

Int J Immunopathol Pharmacol

View full text Add to dashboard Cite

It seems that Porphyromanas gingivalis is carcinogenic, because it activates a number of inflammatory immune responses in the host and causes disorders in bacterial clearance mechanisms. There is little information on the prevalence of this bacterium in cancer patients. The aim of this study was to evaluate and compare the prevalence of P. gingivalis in cancer patients by meta-analysis methods.Different databases including PubMed, EMBASE, the Cochrane Library, Scopus, and ISI web of Knowledge were investigated and eight relevant articles published in 2000-2013 were finally analyzed. Data were analyzed by metaanalysis method, fixed effect model. I² statistics were calculated to examine the heterogeneity of papers. The information was analyzed by R and STATA Ver 12.2.A total of 711 people infected with P. gingivalis were included in this study. In total, the prevalence of P. gingivalis was 40.7% (95% CI, 19.3-62.1). The prevalence of P. gingivalis was evaluated in four case-control studies. The results of this study showed that P. gingivalis increased the chance of cancer development and periodontal disease as much as 1.36 times (OR, 1.36; 95%CI, 0.47-3.97).Although there was no significant correlation between P. gingivalis and cancer, this bacterium increased the chance of cancer and periodontal disease and could be considered as a main potential risk factor.

show abstract

“…Moreover, in an independent validation using new saliva samples from 28 pancreatic cancer patients and 28 healthy controls, only Neisseria elongata and Streptococcus mitis were useful in distinguishing patients with pancreatic cancer from healthy subjects, with an area under the curve value of 0.90 (95% CI: 0.78-0.96, p < 0.0001), a 96.4% sensitivity and a 82.1% specificity (Farrell et al 2012). Moreover, using an immunoblot array, Michaud et al (2013) evaluated antibodies detected against 25 oral bacteria in the serum of 405 pancreatic cancer patients and 416 healthy controls. They observed that 6% of the patients with high antibody titres against Porphyromonas gingivalis (>200 ng/mL) had an adjusted odds ratio (OR) of 2.14 (95% CI: 1.05-4.36) for pancreatic cancer as compared with those with undetectable or lower levels.…”

Section: Gastric Carcinomamentioning

confidence: 99%

The oral cavity microbiota: between health, oral disease, and cancers of the aerodigestive tract

et al. 2017

View full text Add to dashboard Cite

Many studies show that the human microbiome plays a critical role in the chronic pathologies of obesity, inflammatory bowel diseases, and diabetes. More recently, the interaction between cancer and the microbiome has been highlighted. Most studies have focused on the gut microbiota because it represents the most extensive bacterial community, and the body of evidence correlating it with gut syndromes is increasing. However, in the strict sense, the gastrointestinal (GI) tract begins in the oral cavity, and special attention should be paid to the specific flora of this cavity. This study reviewed the current knowledge about the various microbial ecosystems of the upper part of the GI tract and discussed their potential link to carcinogenesis. The overall composition of the microbial communities, as well as the presence or absence of "key species", in relation to carcinogenesis is addressed. Alterations in the oral microbiota can potentially be used to predict the risk of cancer. Molecular advances and the further monitoring of the microbiota will increase our understanding of the role of the microbiota in carcinogenesis and open new perspectives for future therapeutic and prophylactic modalities.Key words: upper aerodigestive, microbiome, oral cavity, carcinogenesis.Résumé : Plusieurs études montrent que le microbiome humain joue un rôle essentiel dans les pathologies chroniques que sont l'obésité, les maladies inflammatoires de l'intestin et le diabète. Plus récemment, l'interaction entre le cancer et le microbiome a été soulignée. La plupart des études se sont concentrées sur le microbiote intestinal car il représente la communauté bactérienne la plus étendue, et l'ensemble des preuves le corrélant avec les syndromes de l'intestin est en croissance. Cependant, au sens strict, le tractus gastro-intestinal (GI) commence dans la cavité orale et une attention spéciale devrait être portée à la flore spécifique de cette cavité. Cette étude fait la synthèse des connaissances actuelles relatives à divers écosystèmes microbiens de la partie supérieure du tractus GI et discute de leur lien potentiel à la carcinogenèse. La composition globale des communautés microbiennes, de même que la présence ou l'absence « d'espèces clés » relativement à la carcinogenèse sont soulevées. Des modifications du microbiote oral peuvent potentiellement être utilisées pour prédire les risques de cancer. Les percées moléculaires et la surveillance accrue du microbiote accroitront notre compréhension du rôle du microbiote dans la carcinogenèse et ouvriront de nouvelles perspectives en vue de modalités thérapeutiques et prophylactiques futures. [Traduit par la Rédaction]

show abstract

Plasma antibodies to oral bacteria and risk of pancreatic cancer in a large European prospective cohort study

Cited by 339 publications

References 53 publications

Pathogenic Microorganisms and Pancreatic Cancer

Pathogenic Microorganisms and Pancreatic Cancer

The prevalence rate of Porphyromonas gingivalis and its association with cancer: A systematic review and meta-analysis

The oral cavity microbiota: between health, oral disease, and cancers of the aerodigestive tract

Contact Info

Product

Resources

About