Plasma antioxidant enzymes and clastogenic factors as possible biomarkers of colorectal cancer risk

Maffei, Francesca; Angeloni, Cristina; Malaguti, Marco; Moraga, Juan Manuel Zolezzi; Pasqui, Francesca; Poli, Carolina; Colecchia, Antonio; Festi, Davide; Hrelia, Patrizia; Hrelia, Silvana

doi:10.1016/j.mrfmmm.2011.06.016

Cited by 29 publications

(20 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, complete neutralization of H 2 O 2 may not occur due to the failure of defense system by sufficient lipid oxidation which further increases the chances of DNA damage, thus, contributing to a growth advantage to the tumorous cell [53] . Our results are in agreement with other reports who found similar alterations in activities of these enzymes in cancer patients [54,55] . Reduction in the activities of these enzymes by LycT supplementation to tumor bearing mice showing the antioxidant capability of LycT to scavenge the free radical formation thus mitigating intracellular oxidative damage.…”

Section: Discussionsupporting

confidence: 94%

“…The increased activity of GSH-Px and decreased levels of GSH may lead to the accumulation of oxidized glutathione (GSSG) which further cannot be converted to GSH due to the reduction in GR activity upon NDEA treatment. Maffei et al [55] has also reported the drop in plasma GR activity in patients suffering from colorectal cancer. Pretreatment with LycT to NDEA mice attenuated the decrease in GR activity probably by radical scavenging potential and increase in GSH level thus maintaining the oxido-reductive balance.…”

Section: Discussionmentioning

confidence: 91%

See 1 more Smart Citation

Lycopene treatment stalls the onset of experimentally induced hepatocellular carcinoma: a radioisotopic, physiological and biochemical analysis

Bhatia¹,

Singh²,

Koul³

2018

View full text Add to dashboard Cite

Tc-mebrofenin excretion. NDEA treatment also caused alterations in the hematological parameters such as hemoglobin, red blood cells, platelets and total leucocyte counts. A significant increase in plasma lipid peroxidation and decrease in reduced glutathione levels with alterations in various enzymatic antioxidants were observed upon NDEA treatment. LycT pre-treatment aided in boosting the antioxidant defense system and ameliorated the inflammatory and hematological alterations. Conclusion:As evident by improved functional, hematological and biochemical markers, it may be inferred that LycT has the potential to delay HCC initiation.

show abstract

Section: Discussionsupporting

confidence: 94%

Section: Discussionmentioning

confidence: 91%

Lycopene treatment stalls the onset of experimentally induced hepatocellular carcinoma: a radioisotopic, physiological and biochemical analysis

Bhatia¹,

Singh²,

Koul³

2018

View full text Add to dashboard Cite

show abstract

“…The GSH level and GST-dependent enzymes have been investigated in blood erythrocytes, tumour tissue, blood serum and plasma (17)(18)(19)(20)(21)(22). However, the data reported in the literature on GSH and GST-dependent enzymes in colorectal cancer is controversial (23,24).…”

Section: Discussionmentioning

confidence: 99%

Glutathione and glutathione S-transferase levels in patients with liver metastases of colorectal cancer and other hepatic disorders

Baltruskeviciene¹,

Kazbarienė²,

Badaras³

et al. 2016

Turk J Gastroenterol

View full text Add to dashboard Cite

“…For example, the correlation between multiple oxidative stress biomarkers and breast cancer, squamous cell carcinomas, leukemia, and colorectal cancer was found (106,221,390,400). As discussed later in more detail, there are data showing that diet composition, especially the supplementation with antioxidants, influence the plasma or urinary levels of oxidative stress markers (see sections VI and VII) (48,101,232,247).…”

Section: The Limitations Of Oxidation Markers In Usementioning

confidence: 96%

Nutritional Countermeasures Targeting Reactive Oxygen Species in Cancer: From Mechanisms to Biomarkers and Clinical Evidence

Samoylenko

Hossain²,

Mennerich³

et al. 2013

Antioxidants & Redox Signaling

View full text Add to dashboard Cite

Reactive oxygen species (ROS) exert various biological effects and contribute to signaling events during physiological and pathological processes. Enhanced levels of ROS are highly associated with different tumors, a Western lifestyle, and a nutritional regime. The supplementation of food with traditional antioxidants was shown to be protective against cancer in a number of studies both in vitro and in vivo. However, recent largescale human trials in well-nourished populations did not confirm the beneficial role of antioxidants in cancer, whereas there is a well-established connection between longevity of several human populations and increased amount of antioxidants in their diets. Although our knowledge about ROS generators, ROS scavengers, and ROS signaling has improved, the knowledge about the direct link between nutrition, ROS levels, and cancer is limited. These limitations are partly due to lack of standardized reliable ROS measurement methods, easily usable biomarkers, knowledge of ROS action in cellular compartments, and individual genetic predispositions. The current review summarizes ROS formation due to nutrition with respect to macronutrients and antioxidant micronutrients in the context of cancer and discusses signaling mechanisms, used biomarkers, and its limitations along with large-scale human trials.

show abstract

Plasma antioxidant enzymes and clastogenic factors as possible biomarkers of colorectal cancer risk

Cited by 29 publications

References 37 publications

Lycopene treatment stalls the onset of experimentally induced hepatocellular carcinoma: a radioisotopic, physiological and biochemical analysis

Lycopene treatment stalls the onset of experimentally induced hepatocellular carcinoma: a radioisotopic, physiological and biochemical analysis

Glutathione and glutathione S-transferase levels in patients with liver metastases of colorectal cancer and other hepatic disorders

Nutritional Countermeasures Targeting Reactive Oxygen Species in Cancer: From Mechanisms to Biomarkers and Clinical Evidence

Contact Info

Product

Resources

About