Plasma apo/lipoproteins disturbances as a precondition for metabolic syndrome in HCV seronegative heroin addicts

Pereska, Zanina; Boz̆inovska, C.; Dimitrovski, Cedomir; Petkovska, Lidija; Cibisev, Andon; Jurukov, Irena

doi:10.3109/00952990.2011.563335

Cited by 7 publications

(3 citation statements)

References 24 publications

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“…Such variations in the lipid profile of individuals with OUD has been previously observed [24–26]. They have been associated with an insulin resistance state in subjects who consume heroin and/or receive opioid agonist therapy with methadone [27–30], In fact, the triglyceride/HDL‐c ratio and the hypertriglyceridaemic waist phenotype, surrogate markers of insulin resistance [44], were more prevalent in individuals with OUD in our study.…”

Section: Discussionsupporting

confidence: 77%

“…In the general population, hypertension, hypercholesterolemia and diabetes are the main cardiovascular risk factors [23]. In contrast, preliminary research has shown that heroin addiction and opioid agonist therapy lead to an increased incidence of atherogenic dyslipidaemia, decreased high-density lipoprotein cholesterol (HDLc), apolipoproteins apoA-I and apoB, and raised triglyceride concentrations [24][25][26], which have been associated with an insulin resistance state [27][28][29][30]. The lipid profile could, however, be influenced by other factors such as chronic viral infections, antipsychotic medication and gender differences [23].…”

Section: Introductionmentioning

confidence: 99%

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High cardiovascular risk in older patients with opioid use disorder: Differences with the general population

Vallecillo

Pedro‐Botet

Fernández

et al. 2022

Drug and Alcohol Review

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Introduction Cardiovascular disease is a health concern in ageing population with opioid use disorders (OUD). The study aims to analyse the cardiovascular risk factors in individuals with OUD. Methods An observational study was carried out to compare cardiovascular risk factors of adults >50 years with OUD on methadone therapy from public outpatient drug treatment centres, with that of an age‐ and gender‐matched sample (ratio of 1:5) of subjects from a sample of the Spanish population (REGICOR cohort). High cardiovascular risk (HCVR) at 10 years was defined according to Framingham‐REGICOR and SCORE risk functions. Results The individuals studied included 94 people with OUD and 495 from the general population; the mean age was 55.7 ± 4.8 years and 432 (72.7%) were men. Obesity (21.2% vs. 35.2%), hypertension (26.3% vs. 42.1%), total cholesterol (30.3% vs. 65.4%) and LDL‐cholesterol ≥130 mg/dL (27.2% vs. 59.3%) were significantly more prevalent in the general population group, while tobacco smoking (96.0% vs. 25.9%), low HDL‐cholesterol (46.5% vs. 21.2%), hypertriglyceridaemia (39.4% vs. 18.8%) and atherogenic dyslipidaemia (30.3% vs. 10.5%) were significantly higher in individuals with OUD. Differences in abdominal obesity (62.6% vs. 65.3%) were not significant. HCVR was more prevalent in patients with OUD: 15.2% versus 5.8% (Framingham‐REGICOR function) and 21.2% versus 11.3% (SCORE function). Discussion and Conclusions Older adults with OUD on methadone therapy have a different prevalence of cardiovascular risk factors and HCVR than the general population. Preventive measures, particularly tobacco smoking cessation and weight control, should be included in the routine care of individuals with OUD.

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Section: Discussionsupporting

confidence: 77%

Section: Introductionmentioning

confidence: 99%

High cardiovascular risk in older patients with opioid use disorder: Differences with the general population

Vallecillo

Pedro‐Botet

Fernández

et al. 2022

Drug and Alcohol Review

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“…Our finding is also consistent with the reported increase in TG and decrease in HDL with heroin use by a study from the West. [28]…”

Section: Discussionmentioning

confidence: 99%

Metabolic syndrome among substance dependent men: A study from north India

et al. 2013

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Background:Substance abuse, alcohol in particular, is associated with increased risk of diabetes and metabolic syndrome (MS). The relationship between the substance abuse and MS is complex and the literature is sparse.Objectives:The present research was aimed to study the prevalence and predictors of MS among outpatients with substance dependence.Materials and Methods:Patients with substance dependence were recruited from a deaddiction center in North India, who attended outpatient clinic from 1st January, 2010-31st December, 2010. MS was assessed using International Diabetes Federation (IDF) criteria.Results:Out of 250 subjects, 34 (13.6%) of the subjects met the IDF criteria for MS and highest being in alcohol group (21.6%). The commonest abnormality was increased triglycerides (TG; 54%) and increased waist circumference (36.8%). Age, body weight, body mass index, and obesity were significant predictor of MS.Conclusion:MS was highest in subjects with alcohol dependence with the commonest abnormality of TG and blood pressure. Hence, routine screening is advisable in this population to address emerging MS.

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Plasma Triglyceride Levels May Modulate Hepatitis C Viral Replication

et al. 2014

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There are: (1) important differences in lipid classes, number and the size of lipid particles exist between hepatitis C virus infected and noninfected liver disease groups, (2) the serum total triglyceride and the LDL levels correlate significantly with the hepatitis C viral load and, (3) Serum triglyceride level may play an important role in viral replication. These data further suggest that therapies directed at lowering plasma triglyceride levels may enhance the efficacy of current antiviral treatment regimens.

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Plasma apo/lipoproteins disturbances as a precondition for metabolic syndrome in HCV seronegative heroin addicts

Cited by 7 publications

References 24 publications

High cardiovascular risk in older patients with opioid use disorder: Differences with the general population

High cardiovascular risk in older patients with opioid use disorder: Differences with the general population

Metabolic syndrome among substance dependent men: A study from north India

Plasma Triglyceride Levels May Modulate Hepatitis C Viral Replication

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