2001
DOI: 10.1016/s0002-9440(10)62531-x
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Plasma Apolipoprotein(a) Co-Deposits with Fibrin in Inflammatory Arthritic Joints

Abstract: Extravascular coagulation and diminished fibrinolysis are processes that contribute to the pathology of both inflammatory arthritis and atherosclerosis. We hypothesized that, given its homology with plasminogen, apolipoprotein (apo) (a), the distinctive glycoprotein of the atherogenic lipoprotein (Lp) (a), may be equally implicated in inflammatory arthritis. We detected the presence of apo(a) as part of Lp(a) in human arthritic synovial fluid. The abundance of apo(a) in synovial fluid rose in proportion to pla… Show more

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Cited by 20 publications
(15 citation statements)
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“…High levels of lipoproteins and lipids have also been reported to contribute to articular inflammation [79][80][81]; excessive lipids in OA cartilage have been described to determine matrix degradation [82]. In agreement with these observations, increased APOA1 and VDBP levels were observed in OA ( Table 2).…”
Section: Discussionsupporting
confidence: 70%
“…High levels of lipoproteins and lipids have also been reported to contribute to articular inflammation [79][80][81]; excessive lipids in OA cartilage have been described to determine matrix degradation [82]. In agreement with these observations, increased APOA1 and VDBP levels were observed in OA ( Table 2).…”
Section: Discussionsupporting
confidence: 70%
“…The maximal stimulation was observed when LDL concentration reached 200 g/ml and higher. Because the extravascular LDL concentration is ‫ف‬ 100 g/ml (14), these results indicate that the p38 MAPK pathway can be activated by physiological concentrations of LDLs in fibroblasts. The maximal p38 MAPK response is, however, observed at higher, pathological, extravascular concentrations of these lipoproteins.…”
Section: Ldls Activate the P38 But Not The Jnk Mapk Pathway In Human mentioning
confidence: 78%
“…The extravascular LDL concentration is much lower, however. Measured in human synovial fluid samples, the extravascular LDL concentration was found to be about five times lower than the blood concentration (14). Therefore, leakage of LDLs from the vascular space (as a result of blood vessel microhemorrhages for example) would induce a local increase in the LDL concentration in the connective tissue surrounding the blood vessels.…”
Section: Discussionmentioning
confidence: 93%
“…Aufgrund der Vermutung, dass apo(a) wegen seiner Homologie zu Plasminogen eine Rolle bei der entzündlichen Arthritis spielt, untersuchten Busso et al humane arthritische Synovialflüssigkeit und konnten in dieser apo(a), welches aus der Zirkulation stammte, nachweisen, und zwar proportional zum Plasmaspiegel des Lp(a) [11]. In Synovialgewebe trat apo(a) zusammen mit Fibrin auf.…”
Section: Lp(a) Und Thrombotische Komplikationenunclassified
“…[19] Endstadium Nierenerkrankung 138 Blutproben Lp(a) erhöht, apo(a)-Isoform ohne Einfluss + Kronenberg et al [36] Endstadium Nierenerkrankung 702 Blutproben Lp(a) erhöht + Hirata et al [29] Nierenerkrankung 152 Blutproben (Dialysepatienten) Lp(a) erhöht + Soulat et al [67] Idiopathisches nephrotisches 61 Blutproben (Kinder) Lp(a) erhöht + Syndrom Cerinic et al [13] Systemische Sklerose 29 Blutproben Lp(a) erhöht + Ignatescu et al [32] Chronisch thrombo-40 Blutproben Lp(a) embolische pulmonale Hypertonie erhöht + Atsumi et al [3] Anti-Phospholipid-Syndrom 68 Blutproben Lp(a) erhöht + Asanuma et al [2] Rheumatoide Arthritis 131 Blutproben Lp(a) erhöht + Borba et al [8] Systemischer Lupus 34 Blutproben Lp(a) erhöht + erythematodes Busso et al [11] Entzündliche Arthritis 32 Proben Synovialflüssigkeit, Lp(a) erhöht, in Flüssigkeit apo (a) als Teil + 7 Proben Synovialgewebe von Lp(a), in Gewebe apo(a) und Fibrin [19] Endstadium Nierenerkrankung 138 Blutproben Lp(a) erhöht, apo(a)-Isoform ohne Einfluss + Kronenberg et al [36] Endstadium Nierenerkrankung 702 Blutproben Lp(a) erhöht + Hirata et al [29] Nierenerkrankung 152 Blutproben (Dialysepatienten) Lp(a) erhöht + Soulat et al [67] Idiopathisches nephrotisches 61 Blutproben (Kinder) Lp(a) erhöht + Syndrom Cerinic et al [13] Systemische Sklerose 29 Blutproben Lp(a) erhöht + Ignatescu et al [32] Chronisch thrombo-40 Blutproben Lp(a) embolische pulmonale Hypertonie erhöht + Atsumi et al [3] Anti-Phospholipid-Syndrom 68 Blutproben Lp(a) erhöht + Asanuma et al [2] Rheumatoide Arthritis 131 Blutproben Lp(a) erhöht + Borba et al [8] Systemischer Lupus 34 Blutproben Lp(a) erhöht + erythematodes Busso et al [11] Entzündliche Arthritis 32 Proben Synovialflüssigkeit, Lp(a) erhöht, in Flüssigkeit apo (a) als Teil + 7 Proben Synovialgewebe von Lp(a), in Gewebe apo(a) und Fibrin…”
Section: Schlussfolgerungunclassified