Plasma Arginine-Vasopressin Levels During Infusion of Synthetic Atrial Natriuretic Peptide on Different Sodium Intakes in Man

Mp, Gnädinger; Weidmann, P; Rascher, Wolfgang; Re, Lang; Hellmüller, Beat; De, Uehlinger

doi:10.1097/00004872-198610000-00016

Cited by 12 publications

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“…A similar finding has been reported by some studies but not others, in man [3,9]. In this study we found that ANF infusion did not decrease AVP levels.…”

Section: Pisupporting

confidence: 93%

Arginine vasopressin dissociates the diuresis and natriuresis due to atrial natriuretic factor in man

McMurray

Forsling

Struthers

1988

Eur J Clin Investigation

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The possible interaction between arginine vasopressin (AVP) and atrial natriuretic factor (ANF) in the control of urinary sodium and water excretion was investigated in man. Nine healthy male volunteers undergoing stable maximal water diuresis were studied on four separate occasions. Atrial natriuretic factor 15 pmol kg-1 min-1 or placebo (P) was concomitantly administered against a background infusion of either AVP 0.003 pmol kg-1 min-1 or P; thus the combinations P + P, AVP + P, P + ANF and AVP + ANF were studied. Atrial natriuretic factor caused a significant increase in sodium excretion (UNaV) [+56%], urinary flow rate (V) [+17%] and free water clearance (CH2O) [+23%]; creatinine clearance (Ccr) did not change. Arginine vasopressin reduced V (-58%) and CH2O (-68%) but did not alter UNaV or Ccr. On the AVP + ANF study day, UNaV increased (+64%) as with P + ANF, but V (-44%) and CH2O (-52%) continued to decrease below baseline levels; analysis of variance showed this antidiuresis reflected the prevalent effect of AVP rather than any specific interaction. These results show that AVP is able to dissociate the natriuretic and diuretic effects of ANF.

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“…A similar finding has been reported by some studies but not others, in man [3,9]. In this study we found that ANF infusion did not decrease AVP levels.…”

Section: Pisupporting

confidence: 93%

Arginine vasopressin dissociates the diuresis and natriuresis due to atrial natriuretic factor in man

McMurray

Forsling

Struthers

1988

Eur J Clin Investigation

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“…In the latter setting, a direct renin-inhibitory influence of aANP is probably counteracted by stimulatory signals resulting from hemoconcentration. decreased BP and sympathetic activation [62], Plasma AVP levels were unaltered during high-dose aANP infusion in normal subjects on low, normal and high sodium intakes [20,75] Considering possible humoral mediators, aldosterone inhibition develops its effects on tubular sodium trans port too slowly to be a relevant determinant of the initial natriuresis occurring within a few minutes after the start of infusions of synthetic aANP. However, reduced aldo sterone levels should promote sodium excretion in the established phase of increased plasma ANP concentra tions.…”

Section: Effects Of Aanp In Normal Humansmentioning

confidence: 99%

Atrial Natriuretic Peptide in Man

Weidmann¹,

Saxenhofer²,

Ferrier³

et al. 1988

Am J Nephrol

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Natriuretic Peptides and Normal Body Fluid Regulation

Bie

2018

Comprehensive Physiology

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Natriuretic peptides are structurally related, functionally diverse hormones. Circulating atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) are delivered predominantly by the heart. Two C-type natriuretic peptides (CNPs) are paracrine messengers, notably in bone, brain, and vessels. Natriuretic peptides act by binding to the extracellular domains of three receptors, NPR-A, NPR-B, and NPR-C of which the first two are guanylate cyclases. NPR-C is coupled to inhibitory proteins. Atrial wall stress is the major regulator of ANP secretion; however, atrial pressure changes plasma ANP only modestly and transiently, and the relation between plasma ANP and atrial wall tension (or extracellular volume or sodium intake) is weak. Absence and overexpression of ANP-related genes are associated with modest blood pressure changes. ANP augments vascular permeability and reduces vascular contractility, renin and aldosterone secretion, sympathetic nerve activity, and renal tubular sodium transport. Within the physiological range of plasma ANP, the responses to step-up changes are unimpressive; in man, the systemic physiological effects include diminution of renin secretion, aldosterone secretion, and cardiac preload. For BNP, the available evidence does not show that cardiac release to the blood is related to sodium homeostasis or body fluid control. CNPs are not circulating hormones, but primarily paracrine messengers important to ossification, nervous system development, and endothelial function. Normally, natriuretic peptides are not powerful natriuretic/diuretic hormones; common conclusions are not consistently supported by hard data. ANP may provide fine-tuning of reno-cardiovascular relationships, but seems, together with BNP, primarily involved in the regulation of cardiac performance and remodeling. © 2017 American Physiological Society. Compr Physiol 8:1211-1249, 2018.

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Plasma Arginine-Vasopressin Levels During Infusion of Synthetic Atrial Natriuretic Peptide on Different Sodium Intakes in Man

Cited by 12 publications

References 0 publications

Arginine vasopressin dissociates the diuresis and natriuresis due to atrial natriuretic factor in man

Arginine vasopressin dissociates the diuresis and natriuresis due to atrial natriuretic factor in man

Atrial Natriuretic Peptide in Man

Natriuretic Peptides and Normal Body Fluid Regulation

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