Plasma Ascorbic Acid Concentrations in Osteoporotic Outpatients

Bhambhani, M.; Bates, Christopher J.; Crisp, A. J.

doi:10.1093/rheumatology/31.2.142

Cited by 4 publications

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“…However, by estimating bone mass from metacarpal radiogrammetry, a relationship between ascorbic acid status and osteoporosis could not be demonstrated [13]. In a study of 20 patients with osteoporotic fractures, their plasma ascorbic acid concentration was not reduced compared to a smaller, mixed control group [14]. Recently, ascorbic acid concentration in white blood cells was reported to be reduced in 21 elderly hip fracture patients [15], but the values in the patients were not compared to age-and sex-matched controls.…”

Section: Serum Ascorbic Acid In Hip Fracture 227mentioning

confidence: 98%

Low levels of serum ascorbic acid in elderly patients with hip fracture

Falch

Mowé

Bøhmer

1998

Scandinavian Journal of Clinical and Laboratory Investigation

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The serum concentration of ascorbic acid was measured in 40 elderly patients with a recent hip fracture and compared to values measured in 102 home-living elderly. The concentrations were 37 +/- 22 mumol l-1 vs 50 +/- 29 mumol l-1 (p < 0.01). Among the patients admitted from home-living conditions and controls, 20 pairs could be matched with respect to age, sex and season for the test. Serum ascorbic acid concentration was significantly lower in the hip fracture patients (34 +/- 19 mumol l-1 vs 54 +/- 30 mumol l-1, p < 0.01). In the matched pairs, a seasonal variation in serum ascorbic acid concentration was found in the controls, but not in the hip fracture patients. As previous studies have found decreased concentrations of several nutritional factors in hip fracture patients, our findings might indicate that a reduced serum concentration of ascorbic acid could be a part of a general nutritional insufficiency in several patients with hip fracture.

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Section: Serum Ascorbic Acid In Hip Fracture 227mentioning

confidence: 98%

Low levels of serum ascorbic acid in elderly patients with hip fracture

Falch

Mowé

Bøhmer

1998

Scandinavian Journal of Clinical and Laboratory Investigation

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2007

Mosby's Guide to Women's Health

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Relation of Ascorbic Acid to Bone Mineral Density and Self-reported Fractures among US Adults

Simon

Hudes²

2001

American Journal of Epidemiology

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Ascorbic acid is an essential nutrient involved in collagen formation, and its deficiency is associated with abnormal bone development. To examine the relation of ascorbic acid to bone mineral density and the prevalence of self-reported fractures, the authors analyzed data collected from 13,080 adults enrolled in the Third National Health and Nutrition Examination Survey (NHANES III) during 1988-1994. Because they identified three-way interactions among smoking, history of estrogen use, and dietary and serum ascorbic acid in postmenopausal women, they analyzed these relations stratified by smoking and estrogen use. Dietary ascorbic acid intake was independently associated with bone mineral density among premenopausal women (p = 0.002). Among men, serum ascorbic acid was associated in a nonlinear fashion with bone mineral density (p < 0.05), and dietary ascorbic acid intake was associated in a nonlinear fashion with self-reported fracture (p = 0.05). Among postmenopausal women without a history of smoking or estrogen use, serum ascorbic acid was unexpectedly associated with lower bone mineral density (p = 0.01). However, among postmenopausal women with a history of smoking and estrogen use, a standard deviation increase in serum ascorbic acid was associated with a 49% decrease in fracture prevalence (p = 0.001). Dietary and serum ascorbic acid measures were associated inconsistently with bone mineral density and self-reported fracture among adult participants in NHANES III.

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Plasma Ascorbic Acid Concentrations in Osteoporotic Outpatients

Cited by 4 publications

References 0 publications

Low levels of serum ascorbic acid in elderly patients with hip fracture

Low levels of serum ascorbic acid in elderly patients with hip fracture

Bibliography

Relation of Ascorbic Acid to Bone Mineral Density and Self-reported Fractures among US Adults

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