Plasma Ascorbic Acid Concentrations in Prevalent Patients With End-Stage Renal Disease on Hemodialysis

Sirover, William D.; Yu-guan, Liu; Logan, Amanda; Hunter, Krystal; Benz, Robert L.; Prasad, Deepali; Ávila, José G.; Venkatchalam, Thaliga; Weisberg, Lawrence S.; Handelman, Garry J.

doi:10.1053/j.jrn.2014.09.007

Cited by 21 publications

(20 citation statements)

References 42 publications

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“…Recently, an important role of hemodialysis (HD) treatment in the development of vitamin C deficiency has been shown [6]. Whether the same mechanisms apply to vitamin B1 is debatable.…”

Section: Introductionmentioning

confidence: 99%

Thiamine Diphosphate Status and Dialysis-Related Losses in End-Stage Kidney Disease Patients Treated with Hemodialysis

et al. 2017

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Aim: (1) To describe the whole blood content of thiamine diphosphate (TDP), a biologically active form of vitamin B1 in end-stage kidney disease patients treated with hemodialysis (HD); (2) to establish the impact of a single HD procedure on TDP blood concentrations; and (3) to describe potential explanatory variables influencing TDP dialysis related losses, including dialysis prescription, vitamin B1 dietary intake and supplementation. Methods: Single-center, cross-sectional study in 50 clinically stable maintenance HD patients. The assessment of whole blood TDP with the High Performance Liquid Chromatography method, before and after a single, middle-week dialysis session and analysis of clinical and laboratory parameters potentially influencing TDP status Results: We report a significant difference in TDP levels before and after HD sessions - 42.5 (95% CI 38.7-46.2) μg/L and 23.6 (95% CI 18.9-28.2) μg/L, respectively (p = 0.000). The magnitude of intradialytic TDP changes is highly variable among individuals and is negatively associated only with the body weight of the patients (p < 0.013). Vitamin B1 dietary intake and supplementation do not influence whole blood TDP and dialysis-related loss of TDP. Conclusions: TDP, a bioactive compound of vitamin B1, is substantially lost during the HD procedure, and the magnitude of its loss is associated with the patient's body weight but it is not influenced by vitamin B1 dietary intake and standard supplementation dose.

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“…Recently, an important role of hemodialysis (HD) treatment in the development of vitamin C deficiency has been shown [6]. Whether the same mechanisms apply to vitamin B1 is debatable.…”

Section: Introductionmentioning

confidence: 99%

Thiamine Diphosphate Status and Dialysis-Related Losses in End-Stage Kidney Disease Patients Treated with Hemodialysis

et al. 2017

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“…We previously reported on pre-HD plasma AA levels in patients on maintenance HD [6]. The present study details the pre-HD and post-HD plasma Ox levels that were simultaneously measured in this cohort.…”

Section: Introductionmentioning

confidence: 83%

“…Following an established protocol for plasma AA measurement [6], within 30 min of collection into a lithium-heparin tube that had been placed on ice, venous blood (5 mL) was centrifuged at 2500 rpm for 10 min. An aliquot of the plasma (200 μL) was diluted with an equal volume of 10% metaphosphoric acid and frozen at − 80°C until assayed for AA.…”

Section: Study Design Study Population and Laboratory Measurementsmentioning

confidence: 99%

“…Hemodialysis (HD) patients commonly have plasma AA concentrations (P[AA]) below thresholds [6] that may prevent bleeding [7], optimize wound healing [8], and support effective erythropoiesis [9]. When subjects with normal kidney function are administered high doses of AA, they are unable to achieve a P[AA] greater than 100 μM, because of urinary AA loss [10].…”

Section: Introductionmentioning

confidence: 99%

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Plasma oxalate levels in prevalent hemodialysis patients and potential implications for ascorbic acid supplementation

Yu-guan

Weisberg

Langman

et al. 2016

Clinical Biochemistry

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“…Com relação à vitamina C, que também pode estar diminuída no paciente renal em virtude de sua perda durante a diálise, 20 as médias de consumo encontradas tanto para homens como para mulheres foram inferiores a EAR, estando a maioria dos pacientes também com alto risco de inadequação do consumo.…”

Section: Discussionunclassified

Inadequação do consumo alimentar de nutrientes antioxidantes em nefropatas crônicos em hemodiálise

Santos¹,

Barroso

Araújo³

et al. 2017

Rev. Med. UFC

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INTRODUÇÃO: o consumo de nutrientes antioxidantes por pacientes em hemodiálise é importante, pois a doença renal pode desencadear desequilíbrio oxidativo decorrente da intensa produção de espécies reativas, falhas nos sistemas antioxidantes e retenção do soluto oxidado. OBJETIVO: avaliar a adequação do consumo alimentar de nutrientes antioxidantes por pacientes renais crônicos em hemodiálise. MÉTODOS: o estudo foi desenvolvido com pacientes em tratamento de hemodiálise, afiliados a duas clínicas especializadas em Fortaleza, Ceará, Brasil. Os dados foram coletados por meio de três recordatórios de 24h e tabulados no programa Excel 2007®. Foram realizadas análises qualitativa e quantitativa da ingestão de selênio, zinco, vitamina A, vitamina C e vitamina E. O estudo incluiu 26 homens e 18 mulheres entre 19 e 83 anos de idade. RESULTADOS: encontraram-se médias de ingestão abaixo da EAR (Estimated Average Requeriment) de zinco, vitamina A, C e E e prevalências de risco de inadequação superior a 50% para todos os micronutrientes analisados, exceto o selênio. A ingestão de vitamina E foi inferior a EAR em 100% dos pacientes. CONCLUSÃO: os pacientes renais crônicos em hemodiálise se encontravam com ingestão inadequada de micronutrientes antioxidantes, contribuindo para o aumento do estresse oxidativo.

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Plasma Ascorbic Acid Concentrations in Prevalent Patients With End-Stage Renal Disease on Hemodialysis

Cited by 21 publications

References 42 publications

Thiamine Diphosphate Status and Dialysis-Related Losses in End-Stage Kidney Disease Patients Treated with Hemodialysis

Thiamine Diphosphate Status and Dialysis-Related Losses in End-Stage Kidney Disease Patients Treated with Hemodialysis

Plasma oxalate levels in prevalent hemodialysis patients and potential implications for ascorbic acid supplementation

Inadequação do consumo alimentar de nutrientes antioxidantes em nefropatas crônicos em hemodiálise

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