Plasma basic fibroblast growth factor is correlated with plasminogen activator inhibitor–1 concentration in adults from the Veterans Affairs Diabetes Trial

Zimering, Mark B; Luo, Ping; Möritz, Thomas

doi:10.1016/j.metabol.2008.06.012

Cited by 8 publications

(9 citation statements)

References 36 publications

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“…The level was higher in patients with poor glycemic control and those with microvascular complications which might reflect widespread endothelial injury in them. In agreement with the present study, Zimering et al [59] reported elevated plasma b-FGF in a subgroup of non-Hispanic white patients with advanced T2DM. Angiogenic growth factors unresponsiveness of diabetic patients could be attributed at least partially to known glycation of them and their receptors [47].…”

Section: Discussionsupporting

confidence: 93%

Vasculopathy in type 2 diabetes mellitus: role of specific angiogenic modulators

et al. 2011

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Type 2 diabetes mellitus (T2DM) is largely defined by hyperglycemia that promotes vascular complications. Abnormal angiogenesis has been claimed to have a role in this disease. This study aimed to investigate serum levels of both conventional and other markers of angiogenesis not well studied before in diabetes, and to correlate findings with age of the patients, glycemic control, presence of microvascular complications, and oxidative stress. Thirty-eight patients with T2DM and 13 age- and sex-matched healthy persons representing controls were recruited. Serum levels of basic fibroblast growth factor (b-FGF) was measured by immunosorbent assay kit; advanced glycosylation end products, platelet-derived endothelial cell growth factor (PD-ECGF), cathepsin-D (CD), gangliosides, hyaluronic acid (HA), nitric oxide (NO), lipid peroxides (LPER), superoxide dismutase, and total thiols by chemical methods; and copper (Cu) by atomic absorption flame photometry. Advanced glycosylation end products and angiogenic factors (b-FGF, PD-ECGF, CD, gangliosides, HA, and Cu) were significantly higher in patients than controls. Oxidative stress markers, NO, and LPER were significantly higher while total thiols were significantly lower in patients than controls. These changes were more pronounced with age, poor glycemic control, and presence of microvascular complications. Angiogenesis dysfunction coinciding with elevated levels of many angiogenic growth factors may point to their malfunctioning due to oxidative stress and/or protein glycation at the factor and the receptor levels. This necessitates further investigations.

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Section: Discussionsupporting

confidence: 93%

Vasculopathy in type 2 diabetes mellitus: role of specific angiogenic modulators

et al. 2011

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“…Our findings of generally low plasma bFGF among diabetic glaucoma or suspects is consistent with an earlier report of a significant association between low plasma bFGF and African-American race in a multi-ethnic VADT substudy of older adults having type 2 diabetes (Zimering et al, 2008). Higher mean diastolic blood pressure in the current diabetic glaucoma group may reflect (in part) inclusion of a higher proportion of African subjects.…”

Section: Discussionsupporting

confidence: 92%

Anti-Neurotrophic Effects from Autoantibodies in Adult Diabetes Having Primary Open Angle Glaucoma or Dementia

Zimering¹,

Möritz²,

Donnelly³

2013

Front. Endocrinol.

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Aim: To test for anti-endothelial and anti-neurotrophic effects from autoantibodies in subsets of diabetes having open-angle glaucoma, dementia, or control subjects.Methods: Protein-A eluates from plasma of 20 diabetic subjects having glaucoma or suspects and 34 age-matched controls were tested for effects on neurite outgrowth in rat pheochromocytoma PC12 cells or endothelial cell survival. The mechanism of the diabetic glaucoma autoantibodies’ neurite-inhibitory effect was investigated in co-incubations with the selective Rho kinase inhibitor Y27632 or the sulfated proteoglycan synthesis inhibitor sodium chlorate. Stored protein-A eluates from certain diabetic glaucoma or dementia subjects which contained long-lasting, highly stable cell inhibitory substances were characterized using mass spectrometry and amino acid sequencing.Results: Diabetic primary open angle glaucoma (POAG) or suspects (n = 20) or diabetic dementia (n = 3) autoantibodies caused significantly greater mean inhibition of neurite outgrowth in PC12 cells (p < 0.0001) compared to autoantibodies in control diabetic (n = 24) or non-diabetic (n = 10) subjects without glaucoma (p < 0.01). Neurite inhibition by the diabetic glaucoma autoantibodies was completely abolished by 10 μM concentrations of Y27632 (n = 4). It was substantially reduced by 30 mM concentrations of sodium chlorate (n = 4). Peak, long-lasting activity survived storage ×5 years at 0–4°C and was associated with a restricted subtype of Ig kappa light chain. Diabetic glaucoma or dementia autoantibodies (n = 5) caused contraction and process retraction in quiescent cerebral cortical astrocytes effects which were blocked by 5 μM concentrations of Y27632.Conclusion: These data suggest that autoantibodies in subsets of adult diabetes having POAG (glaucoma suspects) and/or dementia inhibit neurite outgrowth and promote a reactive astrocyte morphology by a mechanism which may involve activation of the RhoA/p160 ROCK signaling pathway.

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“…bFGF is the subsequent crucial angiogenic factor modified by weight loss [78,96]. The correlation between bFGF and abdominal obesity is obscure [40,41], nevertheless we observed a positive correlation between the decrease in bFGF and the reduction in body mass, fat mass, BMI and waist circumference. bFGF changes endothelial angiogenic properties [38].…”

Section: Discussionmentioning

confidence: 52%

“…Tsuboi et al found correlations between bFGF and metalloproteinases in endothelial culture medium and suggested that expression of metalloproteinases is critical for migration and invasiveness of ECs and finally in the tube formations [39]. The clinical data analyzing the correlation between bFGF and abdominal obesity are still inconclusive [40,41].…”

Section: Angiogenesis In Atmentioning

confidence: 99%

Angiogenesis in Adipose Tissue: How can Moderate Caloric Restriction Affects Obesity-Related Endothelial Dysfunction?

Korybalska¹

2018

Endothelial Dysfunction - Old Concepts and New Challenges

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The plasticity of adipose tissue (AT) is related to its angiogenic ability. Angiogenesis is a multistep process which involves endothelial cell (EC) proliferation, migration, invasion and finally tube formation. AT as a secretory organ produces adipokines, which contributes to the development of subclinical inflammation. The inflammation-related adipokines deteriorate EC function and in consequence change the production of endothelial mediators responsible for vascular homeostasis and angiogenesis, leading to cardiovascular diseases (CVD) in obese patients. Additionally, the recent observation suggests that AT is poorly oxygenated in obesity. Hypoxia limits the healthy expansion of AT and stimulates a molecular response, enhancing nuclear factor kappa-B (NF-kB) and hypoxia-inducible factor (HIF-1) expression. HIF-1α induction does not start a normal angiogenic process but rather induces inflammatory response and fibrosis that is strongly associated with insulin resistance (IR). It is believed that EC dysfunction in obesity can be reduced by caloric restriction (CR). Moderate CR reflects a real-life situation and could be optimal to achieve an EC improvement. It reduces adiposity leading to pro-angiogenic, anti-inflammatory and-to a lesser extent-anti-oxidative cellular effects, which not only preserves the healthy EC phenotype but also leads to an improvement of AT remodeling and prevent systemic IR.

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Plasma basic fibroblast growth factor is correlated with plasminogen activator inhibitor–1 concentration in adults from the Veterans Affairs Diabetes Trial

Cited by 8 publications

References 36 publications

Vasculopathy in type 2 diabetes mellitus: role of specific angiogenic modulators

Vasculopathy in type 2 diabetes mellitus: role of specific angiogenic modulators

Anti-Neurotrophic Effects from Autoantibodies in Adult Diabetes Having Primary Open Angle Glaucoma or Dementia

Angiogenesis in Adipose Tissue: How can Moderate Caloric Restriction Affects Obesity-Related Endothelial Dysfunction?

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