Plasma bioavailability and regional brain distribution of polyphenols from apple/grape seed and bilberry extracts in a young swine model

Chen, Tzu‐Ying; Kritchevsky, Janice; Hargett, Katherine; Feller, K; Klobusnik, Ryan; Song, Brian J.; Cooper, Bruce R.; Jouni, Zeina E.; Ferruzzi, Mario G.; Janle, Elsa M.

doi:10.1002/mnfr.201500224

Cited by 55 publications

(52 citation statements)

References 60 publications

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“…The most recent papers published on the subject are summarized in Table 2 [96,101,[140][141][142][143][144][145][146][147][148][149][150][151]. Anthocyanins are metabolized to a structurally diverse range of metabolites that exhibit dynamic kinetic profiles.…”

Section: Flavonoids -From Biosynthesis To Human Health 212mentioning

confidence: 99%

“…Pharmacokinetic trial to evaluate the bioavailability of anthocyanins and colonic polyphenol metabolites after consumption of aronia berry extract in plasma and urine [96] Evaluation of the protective effects of protocatechuic acid [140] Effects of black raspberry extract and protocatechuic acid on DNA adduct formation and mutagenesis in rat oral fibroblasts [141] Influence of ethanol on the bioavailability and pharmacokinetics of blackberry anthocyanins [142] Pharmacokinetic trial to evaluate the of nanoencapsulation of a phenol extract from grape pomace on human plasma [143] Pharmacokinetic characterization of anthocyanins in overweight adults on the basis of meal timing [97] Determination of cyanidin 3-glucoside in rat brain, liver and kidneys: a short-term pharmacokinetic study [144] Pharmacokinetics, bioavailability and regional brain distribution of polyphenols from apple-grape seed extract mixture and bilberry extract [145] Evaluation of changes in metabolic parameters, and in cardiovascular and liver structure and function in rat due to administration of either cyanidin 3-glucoside or Queen Garnet plum juice [146] Bioavailability and uptake of anthocyanins and their metabolites from an anthocyanins-rich grape/ blueberry juice and smoothie in vivo and in vitro [101] Effects of anthocyanins and their corresponding anthocyanidins on the expression levels of organic anion transporting polypeptides in primary human hepatocytes [147] Effect of flavan-3-ols and anthocyanins against inflammatory-related diseases [148] Anthocyanin pharmacokinetics and dose-dependent plasma antioxidant pharmacodynamics by intake of Montmorency tart cherries in healthy humans [149] Pharmacokinetics of the metabolites of cyanidin-3-glucoside [150] Abundance and persistence of metabolites of anthocyanins in human urine [151] …”

Section: Comments Referencesmentioning

confidence: 99%

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Antioxidant Capacity of Anthocyanin Pigments

Martín¹,

Kuskoski²,

Navas³

et al. 2017

Flavonoids - From Biosynthesis to Human Health

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Anthocyanins are a family of natural pigments classified into the group of flavonoids, considered to be responsible for the color and taste of many fruits and vegetables, i.e. berries. Anthocyanins are common components of the human diet. Besides their interest as colorant because of their coloring properties, the study of anthocyanin compounds stems from their wide applicability in the prevention and even in the treatment of various human diseases. However, various aspects of the pharmacological roles of anthocyanins remain in the dark, having still several obstacles to the development of robust diets or prescribing lines on consumption of anthocyanins. The chemical structure of anthocyanins determines in large measure its capacity and efficacy as an antioxidant agent. In this study, the following aspects are reviewed: the antioxidant effect of anthocyanin pigments; the oxidative stress, the bioavailability after intake and biological aspects of anthocyanins, the method for measuring the antioxidant activity of anthocyanins, the relationship between structure and activity; and the influence of the anthocyanins in the antioxidant activity of wines. Finally an overview of some potential uses in food industry is attempted mainly focusing in the anthocyanin encapsulation topic. Attention has been paid to the more recent publications in the field.

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Section: Flavonoids -From Biosynthesis To Human Health 212mentioning

confidence: 99%

Section: Comments Referencesmentioning

confidence: 99%

Antioxidant Capacity of Anthocyanin Pigments

Martín¹,

Kuskoski²,

Navas³

et al. 2017

Flavonoids - From Biosynthesis to Human Health

View full text Add to dashboard Cite

show abstract

“…In particular, anthocyanins, a unique class of flavonoid compounds, show significant potential as a treatment for neurodegenerative disease for these reasons in addition to the observation that they are among the most commonly consumed polyphenolic species around the world [8]. These compounds, responsible for producing the red, blue, and purple pigmentation of many fruits and vegetables, have received significant attention as neuroprotective agents both in vitro and in vivo; however, the efficacy of these compounds for the treatment of neurodegenerative diseases may be limited by their relatively low bioavailability in the brain following ingestion [9–13]. Indeed, anthocyanins are rapidly absorbed and have been shown to accumulate in several areas of the brain; however, the levels at which anthocyanins accumulate are extremely low at only ~0.2 nmol/g of tissue [9–13].…”

Section: Introductionmentioning

confidence: 99%

Comparison of the Neuroprotective and Anti‐Inflammatory Effects of the Anthocyanin Metabolites, Protocatechuic Acid and 4‐Hydroxybenzoic Acid

Winter

Brenner

Punessen

et al. 2017

Oxidative Medicine and Cellular Longevity

114

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Anthocyanins are being increasingly investigated for their neuroprotective and antineuroinflammatory effects; however, the overall bioavailability of many anthocyanins is relatively low. In contrast, phenolic acids, metabolites of many polyphenols, including anthocyanins, have been shown to accumulate in tissue at higher concentrations than those of parent compounds, suggesting that these metabolites may be the bioactive components of anthocyanin-rich diets. We examined the neuroprotective capacity of two common phenolic acids, 4-hydroxybenzoic acid (HBA) and protocatechuic acid (PCA), in primary cultures of cerebellar granule neurons. Both HBA and PCA are capable of mitigating oxidative stress induced by hydrogen peroxide, which is thought to contribute to neuronal cell death in neurodegeneration. Under conditions of nitrosative stress, which occur during inflammation in the central nervous system, only PCA was neuroprotective, despite similar structural characteristics between HBA and PCA. Intriguingly, this trend was reversed under conditions of excitotoxicity, in which only HBA was neuroprotective. Lastly, we explored the anti-inflammatory activity of these compounds in microglial cells stimulated with lipopolysaccharide. PCA was an effective anti-inflammatory agent, reducing nitric oxide production, while HBA had no effect. These data indicate that phenolic acids possess distinct neuroprotective and anti-inflammatory characteristics that could make them suitable for the treatment of neurodegeneration.The authors would like to dedicate this article to the memory of Matthew Brenner whose great love for research made this work possible

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“…For many TBI animal models, the BBB is breached, allowing easy access for a post-trauma therapeutic intervention. Several studies have used in situ models of the BBB [178][179][180][181] or animal studies 182 to demonstrate a particular compound's ability to cross the BBB.…”

Section: Natural Compounds' Access To the Brainmentioning

confidence: 99%

Natural Compounds as a Therapeutic Intervention following Traumatic Brain Injury: The Role of Phytochemicals

Ansari

2017

Journal of Neurotrauma

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There has been a tremendous focus on the discovery and development of neuroprotective agents that might have clinical relevance following traumatic brain injury (TBI). This type of brain injury is very complex and is divided into two major components. The first component, a primary injury, occurs at the time of impact and is the result of the mechanical insult itself. This primary injury is thought to be irreversible and resistant to most treatments. A second component or secondary brain injury, is defined as cellular damage that is not immediately obvious after trauma, but that develops after a delay of minutes, hours, or even days. This injury appears to be amenable to treatment. Because of the complexity of the secondary injury, any type of therapeutic intervention needs to be multi-faceted and have the ability to simultaneously modulate different cellular changes. Because of diverse pharmaceutical interactions, combinations of different drugs do not work well in concert and result in adverse physiological conditions. Research has begun to investigate the possibility of using natural compounds as a therapeutic intervention following TBI. These compounds normally have very low toxicity and have reduced interactions with other pharmaceuticals. In addition, many natural compounds have the potential to target numerous different components of the secondary injury. Here, we review 33 different plant-derived natural compounds, phytochemicals, which have been investigated in experimental animal models of TBI. Some of these phytochemicals appear to have potential as possible therapeutic interventions to offset key components of the secondary injury cascade. However, not all studies have used the same scientific rigor, and one should be cautious in the interpretation of studies using naturally occurring phytochemical in TBI research.

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Plasma bioavailability and regional brain distribution of polyphenols from apple/grape seed and bilberry extracts in a young swine model

Cited by 55 publications

References 60 publications

Antioxidant Capacity of Anthocyanin Pigments

Antioxidant Capacity of Anthocyanin Pigments

Comparison of the Neuroprotective and Anti‐Inflammatory Effects of the Anthocyanin Metabolites, Protocatechuic Acid and 4‐Hydroxybenzoic Acid

Natural Compounds as a Therapeutic Intervention following Traumatic Brain Injury: The Role of Phytochemicals

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