Plasma, Brain, and Spinal Cord Concentrations of Thiopental Associated with Hyperalgesia in the Rat

Pretreatment with Dexmedetomidine or Thiopental Decreases Myoclonus after Etomidate: A Randomized, Double-Blind Controlled Trial

“…Since phenobarbital has a hyperalgesic effect on GABA-A-specific agonists [21], a low dose of this drug, as used in the current study, causes hyperalgesia (antanalgesia). This study confirms a previous report of hyperalgesia in association with small doses of thiopental [22]. As all operations took less than 50-60 min, thiopental could affect the postoperative period and cause hyperalgesia [23].…”

The suppression of spinal F-waves by propofol does not predict immobility to painful stimuli in humans

“…Evidence for the former is given by studies in rats that indicate substantially less blood flow to the spinal cord than to the brain. 28 In the latter case, the suppression of F-waves by propofol would be only secondary to forebrain effects. Such a possible mechanism seems rather unlikely, as F-waves persist independently of cortical influence.…”

Electroencephalography during ovariohysterectomy in rats anaesthetized with halothane

“…1995). Thiopental was selected as a comparison because it is considered to have anti‐analgesic or hyperalgesic properties (Archer et al. 1994; Tatsuo et al.…”